Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Synthesis and biological activity of derivatives of natural compounds - salinomycin and colchicine

2020/36/T/ST4/00041

Keywords:

natural compounds in vitro studies synthesis stereoselective reactions antitumor activity antibacterial activity antiparasitic activity a correlation between activity and structure

Descriptors:

  • ST4_008:
  • ST4_009:
  • NZ3_001:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Dominika Czerwonka 

Number of co-investigators in the project: 1

Call: ETIUDA 8 - announced on 2019-12-16

Amount awarded: 104 652 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2021-09-30

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei
    Authors:
    Dominika Czerwonka, Yzobelle Barcelos, Dietmar Steverding, Aleksandra Cioch, Adam Huczyński, Michał Antoszczak
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2020, tom: 209, strony: 112900), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2020.112900 - link to the publication
  2. Evaluation of the anticancer activity of singly and doubly modified analogues of C20-epi-salinomycin
    Authors:
    Dominika Czerwonka, Magdalena Mielczarek-Puta, Michał Antoszczak, Aleksandra Cioch, Marta Struga, Adam Huczyński
    Academic press:
    European Journal of Pharmacology (rok: 2021, tom: 908, strony: 174347), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2021.174347 - link to the publication
  3. Synthesis of thiocolchicine amine derivatives and evaluation of their antiproliferative activity
    Authors:
    Dominika Czerwonka, Ewa Maj, Joanna Wietrzyk, Adam Huczyński
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2021, tom: 52, strony: 128382), Wydawca: elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2021.128382 - link to the publication
  4. Activity of singly and doubly modified derivatives of C20-epi-salinomycin against Staphylococcus strains
    Authors:
    Dominika Czerwonka, Małgorzata Podsiad, Joanna Stefańska, Michał Antoszczak, Adam Huczyński
    Academic press:
    The Journal of Antibiotics (rok: 2022, tom: 75, strony: 445–453), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41429-022-00536-4 - link to the publication
  5. Expeditive Synthesis of Potent C20-epi-Amino Derivatives of Salinomycin against Cancer Stem-Like Cells
    Authors:
    Dominika Czerwonka, Sebastian Müller, Tatiana Cañeque, Ludovic Colombeau, Adam Huczyński, Michał Antoszczak, Raphaël Rodriguez
    Academic press:
    ACS Organic & Inorganic Au (rok: 2021, tom: 2, strony: 214–221), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsorginorgau.1c00046 - link to the publication
  6. Photoinduced Skeletal Rearrangement of N-Substituted Colchicine Derivatives
    Authors:
    Dominika Czerwonka, Szymon Sobczak, Tomasz Pędziński, Ewa Maj, Joanna Wietrzyk, Lech Celewicz, Andrzej Katrusiak, Adam Huczyński
    Academic press:
    The Journal of Organic Chemistry (rok: 2020, tom: 86, strony: 11029–11039), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.0c02507 - link to the publication
  7. Photoinduced Skeletal Rearrangement of N-Substituted Colchicine Derivatives
    Authors:
    Dominika Czerwonka, Szymon Sobczak, Tomasz Pędziński, Ewa Maj, Joanna Wietrzyk, Lech Celewicz, Andrzej Katrusiak, Adam Huczyński
    Academic press:
    The Journal of Organic Chemistry (rok: 2020, tom: 86, strony: 11029–11039), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.0c02507 - link to the publication

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