Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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Structural characterization of metallothionein zinc-loaded states and their role in regulation of p53 tumor supressor activity

2020/36/T/ST4/00404

Keywords:

metallothionein zinc p53,

Descriptors:

  • ST4_009:
  • ST4_005:
  • ST4_002:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Manuel David Peris Diaz 

Number of co-investigators in the project: 1

Call: ETIUDA 8 - announced on 2019-12-16

Amount awarded: 130 104 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2021-09-30

Project duration:: 12 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Structural Characterization of Cu(I)/Zn(II)-metallothionein-3 by Ion Mobility Mass Spectrometry and Top-Down Mass Spectrometry
    Authors:
    Manuel David Peris Diaz, Sylwia Wu, Karolina Mosna, Ellen Liggett, Alexey Barkhanskiy, Alicja Orzel, Perdita Barran, Artur Krężel
    Academic press:
    Analytical Chemistry (rok: 2023, tom: 95, strony: 10966-10974), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.analchem.3c00989 - link to the publication
  2. Ion mobility mass spectrometry and molecular dynamics simulations unravel the conformational stability and coordination dynamics of human metallothionein-2 species
    Authors:
    M. D. Peris-Díaz, A Barkhanskiy, E Liggett, P. Barran, A. Krężel
    Status:
    Accepted for publication