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Cardioprotective flavonoids: new regulators of mitochondrial potassium channels?

2020/36/T/NZ1/00116

Keywords:

flavonoids cardioprotection mitochondrial potassium channels

Descriptors:

  • NZ1_003:
  • NZ1_001:
  • NZ1_002:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Rafał Paweł Kampa 

Number of co-investigators in the project: 1

Call: ETIUDA 8 - announced on 2019-12-16

Amount awarded: 138 168 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2022-07-01

Project duration:: 22 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (1)
  1. Flavonoid quercetin abolish paxilline inhibition of the mitochondrial BKCa channel
    Authors:
    Kampa RP, Gliździńska A, Szewczyk A, Bednarczyk P, Filipek S
    Academic press:
    Mitochondrion (rok: 2022, tom: 65, strony: 23-32), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2022.04.005 - link to the publication
  2. Identification of the Large-Conductance Ca 2+-Regulated Potassium Channel in Mitochondria of Human Bronchial Epithelial Cells
    Authors:
    Sęk A, Kampa RP, Kulawiak B, Szewczyk A, Bednarczyk P
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: ), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26113233 - link to the publication
  3. Flavonoids as new regulators of mitochondrial potassium channels: contribution to cardioprotection
    Authors:
    Kampa RP, Sęk A, Bednarczyk P, Szewczyk A, Calderone V, Testai L
    Academic press:
    Journal of Pharmacy and Pharmacology (rok: 2023, tom: 75, strony: 466-481), Wydawca: Oxford academic
    Status:
    Published
    DOI:
    10.1093/jpp/rgac093 - link to the publication
  4. Cytoprotective effects of the flavonoid quercetin by activating mitochondrial BK Ca channels in endothelial cells
    Authors:
    Kampa RP, Sęk A, Szewczyk A, Bednarczyk P
    Academic press:
    Biomedicine & Pharacotherapy (rok: 2021, tom: 142, strony: ), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2021.112039 - link to the publication
  5. Luteolin-induced activation of mitoBKCa channels: undisclosed mechanism of cardioprotection
    Authors:
    Kampa RP, Flori L, Sęk A, Spezzini J, Brogi S, Szewczyk A, Calderone V, Bednarczyk P, Testai L
    Academic press:
    Antioxidants (rok: 2022, tom: 11, strony: 1892), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox11101892 - link to the publication
  1. Patch-Clamp Recording of the Activity of Ion Channels in the Inner Mitochondrial Membrane
    Authors:
    Bednarczyk P, Kampa RP, Gałecka S, Sęk A, Walewska A, Koprowski P
    Book:
    Mitochondrial Mdicine Volume 2: Assessing Mitochondria (rok: 2021, ), Wydawca: Springer Sciences + Business Media, LCC
    Status:
    Published
    DOI:
    10.1007/978-1-0716-1266-8_18 - link to the publication

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