In vivo effects, underlying signaling pathways and mechanism of action of ghrelin receptor agonist against pathological alpha-synuclein accumulation
2019/35/D/NZ7/03200
Keywords
Descriptors
- NZ7_014: Farmacja, farmakoterapia, farmakologia
- NZ4_004: Patofizjologia ogólna
- NZ4_009: Neurobiologia systemowa
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Instytut Farmakologii PAN
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 5
Call
SONATA 15 – announced on 2019-09-16
- Amount awarded
- 1 055 333 PLN
- Project start date
- 2020-07-20
- Project end date
- 2026-07-19
- Project duration
- 72 months (the same as in the proposal)
- Project status
- Pending project
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (2)
-
Alpha-synuclein preformed fibrils: a tool to understand Parkinson's disease and develop disease modifying therapy
- Authors:
- Piotr Chmielarz, Andrii Domanskyi
- Academic press:
- Neural Regeneration Research (year: 2021, volume: 16(11), pages: 2219-2221), Publisher: Wolters Kluwer Medknow Publications, India
- Status:
- Published
- DOI:
- 10.4103/1673-5374.310686 – link to the publication
-
Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons
- Authors:
- Irena Hlushchuk, Justyna Barut, Mikko Airavaara, Kelvin Luk, Andrii Domanskyi, Piotr Chmielarz
- Academic press:
- Biomolecules (year: 2022, volume: 12, pages: 563), Publisher: MDPI AG, Switzerland
- Status:
- Published
- DOI:
- 10.3390/biom12040563 – link to the publication
Articles in post-conference publications (2)
-
Ghrelin receptor agonist MK-0677 alleviates motor impairments caused by spreading alpha-synuclein aggregation in bilaterally alpha-synuclein fibrils injected mice
- Authors:
- Maziarz K., Jankowska-Kieltyka M., Barut J., Chmielarz P.
- Conference:
- Neuroscience Applied tom 1 Abstracts of the 35th ECNP Congress 2022 (year: 2022, volume: 35th ECNP Congress 2022, pages: 100246), Publisher: Elsevier B.V.
- Date:
- conference 15-18.10.2022
- Status:
- Published
- DOI:
- 10.1016/j.nsa.2022.100246 – link to the publication
-
Ghrelin receptor agonist rescues motor impairments and protects dopamine neurons in alpha-synuclein aggregation model
- Authors:
- Katarzyna Maziarz, Monika Jankowska-Kiełtyka, Justyna Barut, Piotr Chmielarz
- Conference:
- Neuroscience Applied (year: 2023, volume: ECNP Workshop for Early Career Scientists in Europe, pages: 101030), Publisher: Elsevier B.V.
- Date:
- conference 16-19 March 2023
- Status:
- Published
- DOI:
- 10.1016/j.nsa.2023.101030. – link to the publication