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Information of the project and the call

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In vivo effects, underlying signaling pathways and mechanism of action of ghrelin receptor agonist against pathological alpha-synuclein accumulation

2019/35/D/NZ7/03200

Keywords:

alpha-synuclein ghrelin receptor dopamine neurons Parkinson's Disease

Descriptors:

  • NZ7_014:
  • NZ4_004:
  • NZ4_009:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Piotr Chmielarz 

Number of co-investigators in the project: 5

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 1 055 333 PLN

Project start date (Y-m-d): 2020-07-20

Project end date (Y-m-d): 2025-07-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (3)
  1. Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons
    Authors:
    Irena Hlushchuk, Justyna Barut, Mikko Airavaara, Kelvin Luk, Andrii Domanskyi, Piotr Chmielarz
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 563), Wydawca: MDPI AG, Switzerland
    Status:
    Published
    DOI:
    10.3390/biom12040563 - link to the publication
  2. Alpha-synuclein preformed fibrils: a tool to understand Parkinson's disease and develop disease modifying therapy
    Authors:
    Piotr Chmielarz, Andrii Domanskyi
    Academic press:
    Neural Regeneration Research (rok: 2021, tom: 16(11), strony: 2219-2221), Wydawca: Wolters Kluwer Medknow Publications, India
    Status:
    Published
    DOI:
    10.4103/1673-5374.310686 - link to the publication
  3. Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons
    Authors:
    Irena Hlushchuk, Justyna Barut, Mikko Airavaara, Kelvin Luk, Andrii Domanskyi, Piotr Chmielarz
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 563), Wydawca: MDPI AG, Switzerland
    Status:
    Published
    DOI:
    10.3390/biom12040563 - link to the publication
  4. Alpha-synuclein preformed fibrils: a tool to understand Parkinson's disease and develop disease modifying therapy
    Authors:
    Piotr Chmielarz, Andrii Domanskyi
    Academic press:
    Neural Regeneration Research (rok: 2021, tom: 16(11), strony: 2219-2221), Wydawca: Wolters Kluwer Medknow Publications, India
    Status:
    Published
    DOI:
    10.4103/1673-5374.310686 - link to the publication
  5. Alpha-synuclein preformed fibrils: a tool to understand Parkinson's disease and develop disease modifying therapy
    Authors:
    Piotr Chmielarz, Andrii Domanskyi
    Academic press:
    Neural Regeneration Research (rok: 2021, tom: 16(11), strony: 2219-2221), Wydawca: Wolters Kluwer Medknow Publications, India
    Status:
    Published
    DOI:
    10.4103/1673-5374.310686 - link to the publication
  1. Ghrelin receptor agonist MK-0677 alleviates motor impairments caused by spreading alpha-synuclein aggregation in bilaterally alpha-synuclein fibrils injected mice
    Authors:
    Maziarz K., Jankowska-Kieltyka M., Barut J., Chmielarz P.
    Conference:
    Neuroscience Applied tom 1 Abstracts of the 35th ECNP Congress 2022 (rok: 2022, tom: 35th ECNP Congress 2022, strony: 100246), Wydawca: Elsevier B.V.
    Data:
    konferencja 15-18.10.2022
    Status:
    Published
    DOI:
    10.1016/j.nsa.2022.100246 - link to the publication
  2. Ghrelin receptor agonist rescues motor impairments and protects dopamine neurons in alpha-synuclein aggregation model
    Authors:
    Katarzyna Maziarz, Monika Jankowska-Kiełtyka, Justyna Barut, Piotr Chmielarz
    Conference:
    Neuroscience Applied (rok: 2023, tom: ECNP Workshop for Early Career Scientists in Europe, strony: 101030), Wydawca: Elsevier B.V.
    Data:
    konferencja 16-19 March 2023
    Status:
    Published
    DOI:
    10.1016/j.nsa.2023.101030. - link to the publication
  3. Ghrelin receptor agonist MK-0677 alleviates motor impairments caused by spreading alpha-synuclein aggregation in bilaterally alpha-synuclein fibrils injected mice
    Authors:
    Maziarz K., Jankowska-Kieltyka M., Barut J., Chmielarz P.
    Conference:
    Neuroscience Applied tom 1 Abstracts of the 35th ECNP Congress 2022 (rok: 2022, tom: 35th ECNP Congress 2022, strony: 100246), Wydawca: Elsevier B.V.
    Data:
    konferencja 15-18.10.2022
    Status:
    Published
    DOI:
    10.1016/j.nsa.2022.100246 - link to the publication

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