Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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Trehalose releasing nanogels for autophagy stimulation

2019/35/O/ST5/02746

Keywords:

trehalose polymerization nanogel autophagy drug delivery neurodegenerative disease

Descriptors:

  • ST5_010:
  • ST5_005:
  • ST4_008:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Śląska, Wydział Chemiczny

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ilona Wioletta Wandzik 

Number of co-investigators in the project: 2

Call: PRELUDIUM BIS 1 - announced on 2019-09-16

Amount awarded: 532 800 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2024-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. pH and Reduction Dual-Responsive Nanogels as Smart Nanocarriers to Resist Doxorubicin Aggregation
    Authors:
    Ali Maruf, Małgorzata Milewska, Anna Lalik, Ilona Wandzik
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 5983), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27185983 - link to the publication
  2. A Simple Synthesis of Reduction-Responsive Acrylamide-Type Nanogels for miRNA Delivery
    Authors:
    Ali Maruf, Małgorzata Milewska, Anna Lalik, Sebastian Student, Ilona Wandzik
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 761), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28020761 - link to the publication
  3. Trehalose-releasing nanogels: A step toward a trehalose delivery vehicle for autophagy stimulation
    Authors:
    Ali Maruf, Małgorzata Milewska, Tibor Kovács, Máté Varga, Tibor Vellai, Anna Lalik, Sebastian Student, Olga Borges, Ilona Wandzik
    Academic press:
    Biomaterials Advances (wcześniej: Materials Science and Engineering C) (rok: 2022, tom: 138, strony: 212969), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioadv.2022.212969 - link to the publication
  4. Trehalose-Bearing Carriers to Target Impaired Autophagy and Protein Aggregation Diseases
    Authors:
    Ali Maruf, Małgorzata Milewska, Mate Varga, Ilona Wandzik
    Academic press:
    Journal of Medicinal Chemistry (rok: 2023, tom: 66, strony: 15613–15628), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.3c01442 - link to the publication
  5. Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis
    Authors:
    Yuan Zhong, Ali Maruf, Kai Qu, Małgorzata Milewska, Ilona Wandzik, Nianlian Mou, Yu Cao, Wei Wu
    Academic press:
    Journal of Nanobiotechnology (rok: 2023, tom: 21, strony: 472), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12951-023-02248-9 - link to the publication
  6. pH and Reduction Dual-Responsive Nanogels as Smart Nanocarriers to Resist Doxorubicin Aggregation
    Authors:
    Ali Maruf, Małgorzata Milewska, Anna Lalik, Ilona Wandzik
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 5983), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27185983 - link to the publication