Projects funded by the NCN
Application of N-(2-thioethyl)glycine analogues in orthogonal cleavage of peptides from solid support
2019/35/N/ST4/00477
Keywords:
peptide cleavage solid-phase peptide synthesis orthogonal SPPS peptide cyclization cyclic peptides N,S-acyl shift native chemical ligation transthioesterification LC-MS HR-MS/MS
Descriptors:
- ST4_008:
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Uniwersytet Wrocławski, Wydział Chemii
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 18 - announced on 2019-09-16
Amount awarded: 139 920 PLN
Project start date (Y-m-d): 2020-07-09
Project end date (Y-m-d): 2023-01-08
Project duration:: 30 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- One-pot cyclization and cleavage of peptides with N-terminal cysteine via the N,S-acyl shift of the N-2-[thioethyl]glycine residue.Authors:Wierzbicka Magdalena, Waliczek Mateusz, Dziadecka Anna, Stefanowicz PiotrAcademic press:The Journal of Organic Chemistry (rok: 2021, tom: 86, strony: 12292–12299), Wydawca: Amercan Chemical SocietyStatus:PublishedDOI:10.1021/acs.joc.1c01045 - link to the publication