Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Differential activity of ribonucleotide repair on leading and lagging DNA strand and its consequences for the mechanism and fidelity of replication of both DNA strands in Escherichia coli cells

2019/35/N/NZ1/03402

Keywords:

ribonucleotide incorporation into DNA Ribonucleotide Excision Repair RNase HII DNA replication replication fidelity leading and lagging DNA strand DNA repair

Descriptors:

  • NZ1_001:
  • NZ1_010:
  • NZ3_001:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Krystian Łazowski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 139 920 PLN

Project start date (Y-m-d): 2020-07-28

Project end date (Y-m-d): 2023-07-27

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Efficient, robust, and versatile fluctuation data analysis using MLE MUtation Rate calculator (mlemur)
    Authors:
    Krystian Łazowski
    Academic press:
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (rok: 2023, tom: 826, strony: 111816), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrfmmm.2023.111816 - link to the publication
  2. Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity
    Authors:
    Alexandra Vaisman, Krystian Łazowski, Martin A. M. Reijns, Erin Walsh, John P. McDonald, Kristiniana C. Moreno, Dominic R. Quiros, Marlen Schmidt, Harald Kranz, Wei Yang, Karolina Makiela-Dzbenska, Roger Woodgate
    Academic press:
    Molecular Microbiology (rok: 2021, tom: 116, strony: 909-925), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/mmi.14779 - link to the publication
  3. Strand specificity of ribonucleotide excision repair in Escherichia coli
    Authors:
    Krystian Łazowski, Mahmood Faraz, Alexandra Vaisman, Nicholas W Ashton, Piotr Jonczyk, Iwona J Fijalkowska, Anders R Clausen, Roger Woodgate, Karolina Makiela-Dzbenska
    Academic press:
    Nucleic Acids Research (rok: 2023, tom: 51, strony: 1766–1782), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkad038 - link to the publication
  4. Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity
    Authors:
    Alexandra Vaisman, Krystian Łazowski, Martin A. M. Reijns, Erin Walsh, John P. McDonald, Kristiniana C. Moreno, Dominic R. Quiros, Marlen Schmidt, Harald Kranz, Wei Yang, Karolina Makiela-Dzbenska, Roger Woodgate
    Academic press:
    Molecular Microbiology (rok: 2021, tom: 116, strony: 909-925), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/mmi.14779 - link to the publication
  5. Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity
    Authors:
    Alexandra Vaisman, Krystian Łazowski, Martin A. M. Reijns, Erin Walsh, John P. McDonald, Kristiniana C. Moreno, Dominic R. Quiros, Marlen Schmidt, Harald Kranz, Wei Yang, Karolina Makiela-Dzbenska, Roger Woodgate
    Academic press:
    Molecular Microbiology (rok: 2021, tom: 116, strony: 909-925), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/mmi.14779 - link to the publication
  6. Strand specificity of ribonucleotide excision repair in Escherichia coli
    Authors:
    Krystian Łazowski, Mahmood Faraz, Alexandra Vaisman, Nicholas W Ashton, Piotr Jonczyk, Iwona J Fijalkowska, Anders R Clausen, Roger Woodgate, Karolina Makiela-Dzbenska
    Academic press:
    Nucleic Acids Research (rok: 2023, tom: 51, strony: 1766–1782), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkad038 - link to the publication

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