Hijacking the ubiquitin-proteasome system by the UL49.5 protein of bovine herpesvirus 1 as an immune evasion strategy – elucidating the mechanism of TAP transporter degradation
2019/35/N/NZ6/00829
Keywords
Descriptors
- NZ6_005: Wirusologia
- NZ1_010: Biologia drobnoustrojów
- NZ3_001: Biologia komórki
Panel
NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution
Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego
Voivodeship: pomorskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 18 – announced on 2019-09-16
- Amount awarded
- 139 200 PLN
- Project start date
- 2020-06-19
- Project end date
- 2023-06-18
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (1)
-
The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation
- Authors:
- Magda Wąchalska, Celeste Riepe, Magdalena J. Ślusarz, Małgorzata Graul, Lukasz S. Borowski, Wenjie Qiao , Michalina Foltyńska, Jan E. Carette, Krystyna Bieńkowska-Szewczyk, Roman J. Szczesny, Ron R. Kopito, Andrea D. Lipińska
- Academic press:
- Proceedings of the National Academy of Sciences (PNAS) (year: 2024, volume: 121, pages: -), Publisher: -
- Status:
- Published
- DOI:
- 10.1073/pnas.2309841121 – link to the publication