Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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SARMs as a modulators of metabolic functions and oxidative stress in adipose and heart tissues in rat obesity model- in vitro and in vivo studies

2019/35/N/NZ7/00738

Keywords:

selective androgen receptor modulator enobosarm adipose tissue heart exercise training

Descriptors:

  • NZ7_012:
  • NZ7_003:
  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Natalia Leciejewska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 209 064 PLN

Project start date (Y-m-d): 2020-06-26

Project end date (Y-m-d): 2024-06-25

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Ostarine-Induced Myogenic Differentiation in C2C12, L6, and Rat Muscles
    Authors:
    Natalia Leciejewska, Paweł A. Kołodziejski, Maciej Sassek, Leszek Nogowski, Emilian Małek, Ewa Pruszyńska - Oszmałek
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(8), strony: 4404), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23084404 - link to the publication
  2. Sex-specific cytotoxicity of ostarine in cardiomyocytes
    Authors:
    Leciejewska, N., Pruszyńska-Oszmałek, E., Nogowski, L., Sassek, M., Strowski, M. Z.,, Kołodziejski, P. A
    Academic press:
    Molecular and cellular endocrinology (rok: 2023, tom: 577, strony: 46032), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mce.2023.112037 - link to the publication
  3. Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
    Authors:
    Leciejewska, N., Jędrejko, K., Gómez-Renaud, V. M., Manríquez-Núñez, J., Muszyńska, B., Pokrywka, A
    Academic press:
    European Journal of Clinical Pharmacology (rok: 2024, tom: 80, strony: 185–202), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00228-023-03592-3 - link to the publication
  4. Ostarine does not enhance the metabolic effect of exercise in obese rats
    Authors:
    Leciejewska, N., Pruszynska-Oszmalek, E., Sassek, M., Głowacki, M., Lehmann, T., Rekas-Dudziak, A., Nogowski, L., Nowak, K. W., Kolodziejski, P. A.
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2023, tom: 74(4), strony: 423-430), Wydawca: Polskie Towarzystwo Fizjologiczne
    Status:
    Published
    DOI:
    10.26402/jpp.2023.4.06 - link to the publication

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