Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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SARMs as a modulators of metabolic functions and oxidative stress in adipose and heart tissues in rat obesity model- in vitro and in vivo studies

2019/35/N/NZ7/00738

Keywords:

selective androgen receptor modulator enobosarm adipose tissue heart exercise training

Descriptors:

  • NZ7_012:
  • NZ7_003:
  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Natalia Leciejewska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 209 064 PLN

Project start date (Y-m-d): 2020-06-26

Project end date (Y-m-d): 2024-06-25

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Sex-specific cytotoxicity of ostarine in cardiomyocytes
    Authors:
    Leciejewska, N., Pruszyńska-Oszmałek, E., Nogowski, L., Sassek, M., Strowski, M. Z.,, Kołodziejski, P. A
    Academic press:
    Molecular and cellular endocrinology (rok: 2023, tom: 577, strony: 45667), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mce.2023.112037 - link to the publication
  2. Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
    Authors:
    Leciejewska, N., Jędrejko, K., Gómez-Renaud, V. M., Manríquez-Núñez, J., Muszyńska, B., Pokrywka, A
    Academic press:
    European Journal of Clinical Pharmacology (rok: 2024, tom: 80, strony: 185–202), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00228-023-03592-3 - link to the publication
  3. Ostarine-Induced Myogenic Differentiation in C2C12, L6, and Rat Muscles
    Authors:
    Natalia Leciejewska, Paweł A. Kołodziejski, Maciej Sassek, Leszek Nogowski, Emilian Małek, Ewa Pruszyńska - Oszmałek
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(8), strony: 4404), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23084404 - link to the publication
  4. Spexin Promotes the Proliferation and Differentiation of C2C12 Cells In Vitro—The Effect of Exercise on SPX and SPX Receptor Expression in Skeletal Muscle In Vivo
    Authors:
    Leciejewska N, Pruszyńska-Oszmałek E, Mielnik K, Głowacki M, Lehmann TP, Sassek M, Gawęda B, Szczepankiewicz D, Nowak KW, Kołodziejski PA
    Academic press:
    Genes (rok: 2022, tom: 13, strony: ), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes13010081 - link to the publication
  5. Ostarine does not enhance the metabolic effect of exercise in obese rats
    Authors:
    Leciejewska, N., Pruszynska-Oszmalek, E., Sassek, M., Głowacki, M., Lehmann, T., Rekas-Dudziak, A., Nogowski, L., Nowak, K. W., Kolodziejski, P. A.
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2023, tom: 74(4), strony: 423-430), Wydawca: Polskie Towarzystwo Fizjologiczne
    Status:
    Published
    DOI:
    10.26402/jpp.2023.4.06 - link to the publication

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