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Information of the project and the call

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Design and synthesis of proteolytically stable and cell permeable activators of human 20S proteasome and assessing their influence on the enzyme activity in cellular models of neurodegenerative diseases

2019/35/O/NZ7/00227

Keywords:

proteasome activator cell permeability proteolytic stability neurodegenerative diseases

Descriptors:

  • NZ7_012:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Elżbieta - Jankowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM BIS 1 - announced on 2019-09-16

Amount awarded: 492 000 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2024-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models
    Authors:
    Chocron ES, Munkácsy E, Kim HS, Karpowicz P, Jiang N, Van Skike CE, DeRosa N, Banh AQ, Palavicini JP, Wityk P, Kalinowski L, Galvan V, Osmulski PA, Jankowska E, Gaczynska M, Pickering AM
    Academic press:
    Science Advances (rok: 2022, tom: 8, strony: eabk2252), Wydawca: American Association for the Advancement of Science's
    Status:
    Published
    DOI:
    10.1126/sciadv.abk2252 - link to the publication
  2. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models
    Authors:
    Chocron ES, Munkácsy E, Kim HS, Karpowicz P, Jiang N, Van Skike CE, DeRosa N, Banh AQ, Palavicini JP, Wityk P, Kalinowski L, Galvan V, Osmulski PA, Jankowska E, Gaczynska M, Pickering AM
    Academic press:
    Science Advances (rok: 2022, tom: 8, strony: eabk2252), Wydawca: American Association for the Advancement of Science's
    Status:
    Published
    DOI:
    10.1126/sciadv.abk2252 - link to the publication

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