Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Pharmacological modulation of histamine H3 and H4 receptors - a new perspective in the treatment of neuropathic pain

2019/35/D/NZ7/01042

Keywords:

neuropathic pain histamine receptor H3 and H4 glia pharmacology

Descriptors:

  • NZ7_014:
  • NZ7_016:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Popiołek-Barczyk 

Number of co-investigators in the project: 4

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 1 183 224 PLN

Project start date (Y-m-d): 2020-06-25

Project end date (Y-m-d): 2025-06-24

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain
    Authors:
    Katarzyna Szczepańska Katarzyna Szczepańska Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland More by Katarzyna Szczepańska, Tadeusz Karcz, Maria Dichiara, Szczepan Mogilski, Justyna Kalinowska-Tłuścik, Bogusław Pilarski, Arkadiusz Leniak, Wojciech Pietruś, Sabina Podlewska, Katarzyna Popiołek-Barczyk, Laura J. Humphrys, M. Carmen Ruiz-Cantero, David Reiner-Link, Luisa Leitzbach, Dorota Łażewska, Steffen Pockes, Michał Górka, Adam Zmysłowski, Thierry Calmels, Enrique J. Cobos, Agostino Marrazzo, Holger Stark, Andrzej J. Bojarski, Emanuele Amata, Katarzyna Kieć-Kononowicz
    Academic press:
    Journal of Medicinal Chemistry (rok: 2023, tom: 66, strony: 9658–9683), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.3c00430 - link to the publication
  2. Złocień maruna – starożytny lek na współczesne choroby
    Authors:
    Katarzyna Popiołek-Barczyk
    Academic press:
    Medycyna Nowożytna (rok: 2023, tom: 29, strony: 73-88), Wydawca: IHN PAN
    Status:
    Published
    DOI:
    10.4467/12311960MN.23.004.18445 - link to the publication
  3. Anti-inflammatory effects of new human histamine H3 receptor ligands with flavonoid structure on BV-2 neuroinflammation
    Authors:
    Ewelina Honkisz-Orzechowska, Katarzyna Popiołek-Barczyk, Zuzanna Linart, Jadwiga Filipek-Gorzała, Anna Rudnicka, Agata Siwek, Tobias Werner, Holger Stark, Jakub Chwastek , Katarzyna Starowicz, Katarzyna Kieć-Kononowicz, Dorota Łażewska
    Academic press:
    Inflammation Research (rok: 2023, tom: 72, strony: 181–194), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00011-022-01658-z - link to the publication
  4. Anti-inflammatory effects of new human histamine H3 receptor ligands with flavonoid structure on BV-2 neuroinflammation
    Authors:
    Ewelina Honkisz-Orzechowska, Katarzyna Popiołek-Barczyk, Zuzanna Linart, Jadwiga Filipek-Gorzała, Anna Rudnicka, Agata Siwek, Tobias Werner, Holger Stark, Jakub Chwastek , Katarzyna Starowicz, Katarzyna Kieć-Kononowicz, Dorota Łażewska
    Academic press:
    Inflammation Research (rok: 2023, tom: 72, strony: 181–194), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00011-022-01658-z - link to the publication