Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Prot-RAN: What drives the RAN translation?

2019/35/D/NZ2/02158

Keywords:

Fragile X-associated tremor/ataxia syndrome non-AUG initiated RAN translation microsatellite expansion disorders CGG repeat expansion RNA-protein interactions

Descriptors:

  • NZ2_003:
  • NZ1_001:
  • NZ5_003:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Honorata Baud 

Number of co-investigators in the project: 2

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 1 425 360 PLN

Project start date (Y-m-d): 2020-11-02

Project end date (Y-m-d): 2025-11-01

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Partners in crime: Proteins implicated in RNA repeat expansion diseases
    Authors:
    Anna Baud, Magdalena Derbis, Katarzyna Tutak, Krzysztof Sobczak
    Academic press:
    WIREs RNA (rok: 2022, tom: 13, strony: 46052), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/wrna.1709 - link to the publication
  2. Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions
    Authors:
    Katarzyna Tutak, Izabela Broniarek, Andrzej Zielezinski, Daria Niewiadomska, Tomasz Skrzypczak, Anna Baud, Krzysztof Sobczak
    Academic press:
    eLife (rok: 2025, tom: 13, strony: 46052), Wydawca: eLife Science Publications, Ltd
    Status:
    Published
    DOI:
    10.7554/eLife.98631.3 - link to the publication
  3. IGF2BPs directly regulate the noncanonical translation of toxic proteins from mutant FMR1 mRNA containing expanded CGG repeats
    Authors:
    Anna Baud, Damini Saha, Tomasz Skrzypczak, Izabela Broniarek, Daria Niewiadomska, Wojciech J. Szlachcic, Małgorzata Borowiak, Rajani Kanth Gudipati, Krzysztof Sobczak
    Academic press:
    Nature Communications (rok: 2025, ), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41467-025-67261-y - link to the publication

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