Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Novel chemoenzymatic strategies in asymmetric synthesis of the selected pharmaceuticals using recombinant oxydoreductases and hydrolases as biocatalysts.

2019/35/D/ST4/01556

Keywords:

Biocatalysis Enzymatic Kinetic Resolution (EKR) Dynamic Kinetic Resolution (DKR) Enantioselective Acylation Lipases Biocatalytic Asymmetric Reduction Ketoreductases Enzymatic Oxidation Laccases Acyl Donors Enantiomeric Pharmaceuticals.

Descriptors:

  • ST4_008:
  • ST4_009:
  • ST4_014:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Warszawska

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paweł Borowiecki 

Number of co-investigators in the project: 4

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 1 068 000 PLN

Project start date (Y-m-d): 2020-07-06

Project end date (Y-m-d): 2025-07-05

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (19)
  1. Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/tempo)-alcohol dehydrogenase system
    Authors:
    Paweł Borowiecki, Aleksandra Rudzka, Tamara Reiter, Wolfgang Kroutil
    Academic press:
    Catalysis Science & Technology (rok: 2022, tom: 12, strony: 4312–4324), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2CY00145D - link to the publication
  2. The First Insight Into the Supramolecular System of D,L-α-Difluoromethylornithine: A New Antiviral Perspective
    Authors:
    Joanna Bojarska, Roger New, Paweł Borowiecki, Milan Remko, Martin Breza, Izabela D. Madura, Andrzej Fruziński, Anna Pietrzak, Wojciech M. Wolf
    Academic press:
    Frontiers in Chemistry (rok: 2021, tom: 9, strony: 679776–679799), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2021.679776 - link to the publication
  3. Vinyl 3-(Dimethylamino)propanoate as an Irreversible Acyl Donor Reagent in a Chromatography-free Lipase-Catalyzed Kinetic Resolution of sec-Alcohols
    Authors:
    Beata Zdun, Paweł Borowiecki
    Academic press:
    ChemBioChem (rok: 2024, tom: 25, strony: e202400394), Wydawca: Wiley-VCH GmbH (John Wiley & Sons, Inc)
    Status:
    Published
    DOI:
    10.1002/cbic.202400394 - link to the publication
  4. Antifungal Polybrominated Proxyphylline Derivative Induces Candida albicans Calcineurin Stress Response in Galleria mellonella
    Authors:
    Małgorzata Gizińska, Anna Staniszewska, Michalina Kazek, Mirosława Koronkiewicz, Łukasz Kuryke, Małgorzata Milner-Krawczyk, Joanna Baran, Paweł Borowiecki, Monika Staniszewska
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2020, tom: brak., strony: 127545–127550), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2020.127545 - link to the publication
  5. Chemoenzymatic Synthesis of Optically Active Ethereal Analogof iso-Moramide—A Novel Potentially Powerful Analgesic
    Authors:
    Paweł Borowiecki
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 11803–11832), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231911803 - link to the publication
  6. Chemoenzymatic synthesis of tenofovir
    Authors:
    Beata Zdun, Tamara Reiter, Wolfgang Kroutil, and Paweł Borowiecki
    Academic press:
    The Journal of Organic Chemistry (rok: 2023, tom: 88, strony: 11045−11055), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.3c01005 - link to the publication
  7. Expanding access to optically active non-steroidal anti-inflammatory drugs via lipase-catalyzed KR of racemic acids using trialkyl orthoesters as irreversible alkoxy group donors
    Authors:
    Beata Zdun, Piotr Cieśla, Jan Kutner, Paweł Borowiecki
    Academic press:
    Catalysts (rok: 2022, tom: 12, strony: 546–566), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal12050546 - link to the publication
  8. Chemoenzymatic Enantioselective and Stereo-Convergent Syntheses of Lisofylline Enantiomers via Lipase-catalyzed Kinetic Resolution and Optical Inversion Approach
    Authors:
    Paweł Borowiecki, Beata Zdun, Maciej Dranka
    Academic press:
    Molecular Catalysis (rok: 2021, tom: brak., strony: 111451–111470), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.mcat.2021.111451 - link to the publication
  9. Synthesis of Novel Acyl Derivatives of 3‐(4,5,6,7‐Tetrabromo‐1H‐benzimidazol‐1‐yl)propan‐1‐ols—Intracellular TBBi‐Based CK2 Inhibitors with Proapoptotic Properties
    Authors:
    Konrad Chojnacki, Patrycja Wińska, Olena Karatsai, Mirosława Koronkiewicz, Małgorzata Milner‐Krawczyk, Monika Wielechowska, Maria Jolanta Rędowicz, Maria Bretner, Paweł Borowiecki
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6261–6283), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126261 - link to the publication
  10. Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol
    Authors:
    Paweł Borowiecki, Beata Zdun, Natalia Popow, Magdalena Wiklińska, Tamara Reiter, Wolfgang Kroutil
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 22150–22160), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2RA04302E - link to the publication
  11. Chemoenzymatic synthesis of tenofovir
    Authors:
    Beata Zdun, Tamara Reiter, Wolfgang Kroutil, and Paweł Borowiecki
    Academic press:
    The Journal of Organic Chemistry (rok: 2023, tom: 88, strony: 11045−11055), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.3c01005 - link to the publication
  12. Chemoenzymatic synthesis of enantiomerically enriched diprophylline and xanthinol nicotinate
    Authors:
    Paweł Borowiecki, Mateusz Młynek, Maciej Dranka
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 106, strony: 104448–104464), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.104448 - link to the publication
  13. Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol
    Authors:
    Paweł Borowiecki, Beata Zdun, Natalia Popow, Magdalena Wiklińska, Tamara Reiter, Wolfgang Kroutil
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 22150–22160), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2RA04302E - link to the publication
  14. Chemoenzymatic Synthesis of Optically Active Ethereal Analogof iso-Moramide—A Novel Potentially Powerful Analgesic
    Authors:
    Paweł Borowiecki
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 11803–11832), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231911803 - link to the publication
  15. Synthesis and Anticancer Activity of Novel Dual Inhibitors of Human Protein Kinases CK2 and PIM-1
    Authors:
    Patrycja Wińska, Monika Wielechowska, Mirosława Koronkiewicz, Paweł Borowiecki
    Academic press:
    Pharmaceutics (rok: 2023, tom: 15, strony: 1991), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15071991 - link to the publication
  16. Chemoenzymatic Synthesis of Optically Active Alcohols Possessing 1,2,3,4-Tetrahydroquinoline Moiety Employing Lipases or Variants of the Acyltransferase from Mycobacterium smegmatis
    Authors:
    Beata Zdun, Izabela Kopińska, Maciej Dranka, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki
    Academic press:
    Catalysts (rok: 2022, tom: 12, strony: 1610-1633), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal12121610 - link to the publication
  17. Biocatalytic hydrogen-transfer to access enantiomerically pure proxyphylline, xanthinol, and diprophylline
    Authors:
    Paweł Borowiecki, Aleksandra Rudzka, Tamara Reiter, Wolfgang Kroutil
    Academic press:
    Bioorganic Chemistry (rok: 2022, tom: 127, strony: 105967–105978), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2022.105967 - link to the publication
  18. From Waste to Value—Direct Utilization of α-Angelica Lactone as a Nonconventional Irreversible Acylating Agent in a Chromatography-Free Lipase-Catalyzed KR Approach toward sec-Alcohols
    Authors:
    Marcin Poterała, Paweł Borowiecki
    Academic press:
    ACS Sustainable Chemistry & Engineering (rok: 2021, tom: 9, strony: 10276–10290), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acssuschemeng.1c02845 - link to the publication
  19. Synthesis of Novel Acyl Derivatives of 3‐(4,5,6,7‐Tetrabromo‐1H‐benzimidazol‐1‐yl)propan‐1‐ols—Intracellular TBBi‐Based CK2 Inhibitors with Proapoptotic Properties
    Authors:
    Konrad Chojnacki, Patrycja Wińska, Olena Karatsai, Mirosława Koronkiewicz, Małgorzata Milner‐Krawczyk, Monika Wielechowska, Maria Jolanta Rędowicz, Maria Bretner, Paweł Borowiecki
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6261–6283), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126261 - link to the publication

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