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Novel chemoenzymatic strategies in asymmetric synthesis of the selected pharmaceuticals using recombinant oxydoreductases and hydrolases as biocatalysts.

2019/35/D/ST4/01556

Keywords

Descriptors

  • ST4_008: Chemia organiczna
  • ST4_009: Chemia biologiczna
  • ST4_014: Kataliza

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Politechnika Warszawska

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Paweł Borowiecki

Number of co-investigators in the project: 4

Call

SONATA 15 – announced on 2019-09-16

Amount awarded
1 068 000 PLN
Project start date
2020-07-06
Project end date
2025-07-05
Project duration
60 months (the same as in the proposal)
Project status
Project completed

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (15)

  1. Synthesis of Novel Acyl Derivatives of 3‐(4,5,6,7‐Tetrabromo‐1H‐benzimidazol‐1‐yl)propan‐1‐ols—Intracellular TBBi‐Based CK2 Inhibitors with Proapoptotic Properties

    Authors:
    Konrad Chojnacki, Patrycja Wińska, Olena Karatsai, Mirosława Koronkiewicz, Małgorzata Milner‐Krawczyk, Monika Wielechowska, Maria Jolanta Rędowicz, Maria Bretner, Paweł Borowiecki
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 6261–6283), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126261 – link to the publication

  2. Antifungal Polybrominated Proxyphylline Derivative Induces Candida albicans Calcineurin Stress Response in Galleria mellonella

    Authors:
    Małgorzata Gizińska, Anna Staniszewska, Michalina Kazek, Mirosława Koronkiewicz, Łukasz Kuryke, Małgorzata Milner-Krawczyk, Joanna Baran, Paweł Borowiecki, Monika Staniszewska
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (year: 2020, volume: brak., pages: 127545–127550), Publisher: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2020.127545 – link to the publication

  3. Biocatalytic hydrogen-transfer to access enantiomerically pure proxyphylline, xanthinol, and diprophylline

    Authors:
    Paweł Borowiecki, Aleksandra Rudzka, Tamara Reiter, Wolfgang Kroutil
    Academic press:
    Bioorganic Chemistry (year: 2022, volume: 127, pages: 105967–105978), Publisher: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2022.105967 – link to the publication

  4. Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol

    Authors:
    Paweł Borowiecki, Beata Zdun, Natalia Popow, Magdalena Wiklińska, Tamara Reiter, Wolfgang Kroutil
    Academic press:
    RSC Advances (year: 2022, volume: 12, pages: 22150–22160), Publisher: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2RA04302E – link to the publication

  5. Chemoenzymatic Enantioselective and Stereo-Convergent Syntheses of Lisofylline Enantiomers via Lipase-catalyzed Kinetic Resolution and Optical Inversion Approach

    Authors:
    Paweł Borowiecki, Beata Zdun, Maciej Dranka
    Academic press:
    Molecular Catalysis (year: 2021, volume: brak., pages: 111451–111470), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.mcat.2021.111451 – link to the publication

  6. Chemoenzymatic synthesis of enantiomerically enriched diprophylline and xanthinol nicotinate

    Authors:
    Paweł Borowiecki, Mateusz Młynek, Maciej Dranka
    Academic press:
    Bioorganic Chemistry (year: 2020, volume: 106, pages: 104448–104464), Publisher: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.104448 – link to the publication

  7. Synthesis and Anticancer Activity of Novel Dual Inhibitors of Human Protein Kinases CK2 and PIM-1

    Authors:
    Patrycja Wińska, Monika Wielechowska, Mirosława Koronkiewicz, Paweł Borowiecki
    Academic press:
    Pharmaceutics (year: 2023, volume: 15, pages: 1991), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15071991 – link to the publication

  8. Chemoenzymatic Synthesis of Optically Active Alcohols Possessing 1,2,3,4-Tetrahydroquinoline Moiety Employing Lipases or Variants of the Acyltransferase from Mycobacterium smegmatis

    Authors:
    Beata Zdun, Izabela Kopińska, Maciej Dranka, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki
    Academic press:
    Catalysts (year: 2022, volume: 12, pages: 1610-1633), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/catal12121610 – link to the publication

  9. Chemoenzymatic Synthesis of Optically Active Ethereal Analogof iso-Moramide—A Novel Potentially Powerful Analgesic

    Authors:
    Paweł Borowiecki
    Academic press:
    International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 11803–11832), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231911803 – link to the publication

  10. Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/tempo)-alcohol dehydrogenase system

    Authors:
    Paweł Borowiecki, Aleksandra Rudzka, Tamara Reiter, Wolfgang Kroutil
    Academic press:
    Catalysis Science & Technology (year: 2022, volume: 12, pages: 4312–4324), Publisher: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2CY00145D – link to the publication

  11. From Waste to Value—Direct Utilization of α-Angelica Lactone as a Nonconventional Irreversible Acylating Agent in a Chromatography-Free Lipase-Catalyzed KR Approach toward sec-Alcohols

    Authors:
    Marcin Poterała, Paweł Borowiecki
    Academic press:
    ACS Sustainable Chemistry & Engineering (year: 2021, volume: 9, pages: 10276–10290), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acssuschemeng.1c02845 – link to the publication

  12. Chemoenzymatic synthesis of tenofovir

    Authors:
    Beata Zdun, Tamara Reiter, Wolfgang Kroutil, and Paweł Borowiecki
    Academic press:
    The Journal of Organic Chemistry (year: 2023, volume: 88, pages: 11045−11055), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.3c01005 – link to the publication

  13. The First Insight Into the Supramolecular System of D,L-α-Difluoromethylornithine: A New Antiviral Perspective

    Authors:
    Joanna Bojarska, Roger New, Paweł Borowiecki, Milan Remko, Martin Breza, Izabela D. Madura, Andrzej Fruziński, Anna Pietrzak, Wojciech M. Wolf
    Academic press:
    Frontiers in Chemistry (year: 2021, volume: 9, pages: 679776–679799), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2021.679776 – link to the publication

  14. Vinyl 3-(Dimethylamino)propanoate as an Irreversible Acyl Donor Reagent in a Chromatography-free Lipase-Catalyzed Kinetic Resolution of sec-Alcohols

    Authors:
    Beata Zdun, Paweł Borowiecki
    Academic press:
    ChemBioChem (year: 2024, volume: 25, pages: e202400394), Publisher: Wiley-VCH GmbH (John Wiley & Sons, Inc)
    Status:
    Published
    DOI:
    10.1002/cbic.202400394 – link to the publication

  15. Expanding access to optically active non-steroidal anti-inflammatory drugs via lipase-catalyzed KR of racemic acids using trialkyl orthoesters as irreversible alkoxy group donors

    Authors:
    Beata Zdun, Piotr Cieśla, Jan Kutner, Paweł Borowiecki
    Academic press:
    Catalysts (year: 2022, volume: 12, pages: 546–566), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/catal12050546 – link to the publication

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