Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Metallofullerenols as a new generation of radioprotective agents – in vitro studies of radical processes in model biological membranes and in cellular model under radiation-induced oxidative stress

2019/35/D/ST4/02627

Keywords:

metallofullerenol ionizing radiation radioprotectors mechanisms toxicology free radicals pulse radiolysis

Descriptors:

  • ST4_009:
  • ST4_017:
  • ST4_018:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Jacek Bogdan Grębowski 

Number of co-investigators in the project: 8

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 762 426 PLN

Project start date (Y-m-d): 2020-07-06

Project end date (Y-m-d): 2025-07-05

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (14)
  1. Fullerenol C60(OH)36 Protects the Antioxidant Enzymes in Human Erythrocytes against Oxidative Damage Induced by High-Energy Electrons
    Authors:
    Grebowski Jacek, Kazmierska-Grebowska Paulina, Cichon Natalia, Konarska Anna, Wolszczak Marian, Litwinienko Grzegorz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45669), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231810939 - link to the publication
  2. Metallofullerenols in biomedical applications
    Authors:
    Grebowski Jacek, Litwinienko Grzegorz
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2022, tom: 238, strony: 45672), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2022.114481 - link to the publication
  3. The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes
    Authors:
    Grebowski, Jacek, Paulina Kazmierska-Grebowska, Natalia Cichon, Piotr Piotrowski, Grzegorz Litwinienko
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 23, strony: 45670), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010119 - link to the publication
  4. Kinetics of Metallofullerenol Reactions with the Products of Water Radiolysis: Implications for Radiotherapeutics
    Authors:
    Jacek Grebowski, Anna Konarska, Piotr Piotrowski, Marian Wolszczak, Grzegorz Litwinienko
    Academic press:
    ACS Applied Nano Materials (rok: 2023, tom: 7, strony: 539–549), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsanm.3c04747 - link to the publication
  5. Fullerenol C60(OH)36 Protects the Antioxidant Enzymes in Human Erythrocytes against Oxidative Damage Induced by High-Energy Electrons
    Authors:
    Grebowski Jacek, Kazmierska-Grebowska Paulina, Cichon Natalia, Konarska Anna, Wolszczak Marian, Litwinienko Grzegorz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45669), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231810939 - link to the publication
  6. The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes
    Authors:
    Grebowski, Jacek, Paulina Kazmierska-Grebowska, Natalia Cichon, Piotr Piotrowski, Grzegorz Litwinienko
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 23, strony: 45670), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010119 - link to the publication
  7. Metallofullerenols in biomedical applications
    Authors:
    Grebowski Jacek, Litwinienko Grzegorz
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2022, tom: 238, strony: 45672), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2022.114481 - link to the publication
  8. Metallofullerenol Gd@C82(OH)22 preserves human erythrocyte plasma membrane integrity from AAPH-induced oxidative stress: Molecular mechanisms and antioxidant activity
    Authors:
    Remigante A, Studzian M, Spinelli S, Piotrowski P, Litwinienko G, Gorny K, Raczynski P, Marino A, Morabito R, Grebowski J.
    Academic press:
    Free Radical Biology and Medicine (rok: 2025, tom: 229, strony: 499-513), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2025.01.052 - link to the publication
  9. The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes
    Authors:
    Grebowski, Jacek, Paulina Kazmierska-Grebowska, Natalia Cichon, Piotr Piotrowski, Grzegorz Litwinienko
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 23, strony: 45670), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010119 - link to the publication
  10. Nanotechnology meets radiobiology: Fullerenols and Metallofullerenols as nano-shields in radiotherapy
    Authors:
    Kazmierska-Grebowska P, Jankowski MM, Obrador E, Kolodziejczyk-Czepas J, Litwinienko G, Grebowski J.
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2025, tom: 184, strony: 117915), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2025.117915 - link to the publication
  11. Fullerenol C60(OH)36 Protects the Antioxidant Enzymes in Human Erythrocytes against Oxidative Damage Induced by High-Energy Electrons
    Authors:
    Grebowski Jacek, Kazmierska-Grebowska Paulina, Cichon Natalia, Konarska Anna, Wolszczak Marian, Litwinienko Grzegorz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45669), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231810939 - link to the publication
  12. Kinetics of Metallofullerenol Reactions with the Products of Water Radiolysis: Implications for Radiotherapeutics
    Authors:
    Jacek Grebowski, Anna Konarska, Piotr Piotrowski, Marian Wolszczak, Grzegorz Litwinienko
    Academic press:
    ACS Applied Nano Materials (rok: 2023, tom: 7, strony: 539–549), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsanm.3c04747 - link to the publication
  13. The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes
    Authors:
    Grebowski, Jacek, Paulina Kazmierska-Grebowska, Natalia Cichon, Piotr Piotrowski, Grzegorz Litwinienko
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 23, strony: 45670), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010119 - link to the publication
  14. Metallofullerenols in biomedical applications
    Authors:
    Grebowski Jacek, Litwinienko Grzegorz
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2022, tom: 238, strony: 45672), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2022.114481 - link to the publication

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