Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Solid-state circular dichroism (CD) spectroscopies as a tool for supporting the development of medicinal chemistry

2019/35/D/ST4/00394

Keywords:

chirality chiroptical methods circular dichroism polymorphism active pharmaceutical ingreedients

Descriptors:

  • ST4_002:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Chemii Organicznej Polska Akademia Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Janusz Górecki 

Number of co-investigators in the project: 6

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 904 800 PLN

Project start date (Y-m-d): 2020-09-01

Project end date (Y-m-d): 2024-08-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Enantioselective Gel Phase Synthesis of Metal–Organic Materials
    Authors:
    D. Ghosh, M. Górecki, G. Pescitelli, K. Kumar Damodaran
    Academic press:
    Angewandte Chemie - International Edition (), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/anie.202107040 - link to the publication
  2. A Holistic Approach to Determining Stereochemistry of Potential Pharmaceuticals by Circular Dichroism with β-Lactams as Test Cases
    Authors:
    M. Górecki, J. Frelek
    Academic press:
    International Journal of Molecular Sciences , Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010273 - link to the publication
  3. Differentiation of solvatomorphs of active pharmaceutical ingredients (API) by solid-state vibrational circular dichroism (VCD)
    Authors:
    J. E. Rode, J. Wasilczenko, M. Górecki
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2024.123851 - link to the publication
  4. Electronic Circular Dichroism Imaging (CDi) casts a new light on the origin of solid-state chiroptical properties
    Authors:
    M. Górecki, F. Lipparini, G. Albano, T. Jávorfi, R. Hussain, G. Siligardi, G. Pescitelli, L. Di Bari
    Academic press:
    Chemistry - A European Journal (), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/chem.202103632 - link to the publication
  5. Towards seeking the right chiroptical tool to assign the stereochemistry of bioactive compounds: Effectiveness, challenges, and perspectives
    Authors:
    M. Górecki, J. Frelek
    Academic press:
    Trends in Analytical Chemistry , Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trac.2021.116428 - link to the publication

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