Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Interaction of natural killer cells with an infected cancer cell population: microfluidics-based experiments and single-cell-level mathematical modeling

2019/34/H/NZ6/00699

Keywords:

innate immune response droplet systems fluorescently tagged proteins stochastic processes mathematical modeling

Descriptors:

  • NZ2_009:
  • NZ6_001:
  • ST8_004:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Lipniacki 

Number of co-investigators in the project: 14

Call: GRIEG 1 - announced on 2019-06-17

Amount awarded: 6 389 850 PLN

Project start date (Y-m-d): 2020-09-01

Project end date (Y-m-d): 2024-04-30

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (24)
  1. SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations
    Authors:
    Frederic Grabowski, Grzegorz Preibisch, Stanisław Giziński, Marek Kochanczyk, Tomasz Lipniacki
    Academic press:
    Viruses (rok: 2021, tom: 13, strony: 392), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v13030392 - link to the publication
  2. Predictive power of non-identifiable models
    Authors:
    Frederic Grabowski, Paweł Nałęcz-Jawecki, Tomasz Lipniacki
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 11143), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-023-37939-8 - link to the publication
  3. Formation of droplets in microfluidic cross-junctions at small capillary numbers: Breakdown of the classical squeezing regime
    Authors:
    Tetuko Kurniawan, Mahsa Sahebdivani, Damian Zaremba, Slawomir Blonski, Piotr Garstecki, Volkert van Steijn, Piotr M. Korczyk
    Academic press:
    Chemical Engineering Journal (rok: 2023, tom: 474, strony: 145601), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cej.2023.145601 - link to the publication
  4. A plausible identifiable model of the canonical NF-κB signaling pathway
    Authors:
    Joanna Jaruszewicz-Błońska, Ilona Kosiuk, Wiktor Prus, Tomasz Lipniacki
    Academic press:
    PLOS One (rok: 2023, tom: 18, strony: b.d.), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0286416 - link to the publication
  5. Application of Polymethylpentene, an Oxygen Permeable Thermoplastic, for Long-Term on-a-Chip Cell Culture and Organ-on-a-Chip Devices
    Authors:
    Linda Sønstevold, Maciej Czerkies, Enrique Escobedo-Cousin, Sławomir Błoński, Elizaveta Vereshchagina
    Academic press:
    Micromachines (rok: 2023, tom: 14, strony: 532), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/mi14030532 - link to the publication
  6. Respiratory syncytial virus protects bystander cells against influenza A virus infection by triggering secretion of type I and type III interferons
    Authors:
    Maciej Czerkies, Marek Kochańczyk, Zbigniew Korwek, Wiktor Prus, Tomasz Lipniacki
    Academic press:
    Journal of Virology (rok: 2022, tom: 96, strony: e01341-22), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/jvi.01341-22 - link to the publication
  7. Application of Polymethylpentene, an Oxygen Permeable Thermoplastic, for Long-Term on-a-Chip Cell Culture and Organ-on-a-Chip Devices
    Authors:
    Linda Sønstevold, Maciej Czerkies, Enrique Escobedo-Cousin, Sławomir Błoński, Elizaveta Vereshchagina
    Academic press:
    Micromachines (rok: 2023, tom: 14, strony: 532), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/mi14030532 - link to the publication
  8. The Spread of SARS-CoV-2 Variant Omicron with a Doubling Time of 2.0–3.3 Days Can Be Explained by Immune Evasion
    Authors:
    Marek Kochanczyk, Frederic Grabowski, Tomasz Lipniacki
    Academic press:
    Viruses (rok: 2022, tom: 14, strony: 294), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v14020294 - link to the publication
  9. The Spread of SARS-CoV-2 Variant Omicron with a Doubling Time of 2.0–3.3 Days Can Be Explained by Immune Evasion
    Authors:
    Marek Kochanczyk, Frederic Grabowski, Tomasz Lipniacki
    Academic press:
    Viruses (rok: 2022, tom: 14, strony: 294), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v14020294 - link to the publication
  10. Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts
    Authors:
    Robert C. Mines, Tomasz Lipniacki, Xiling Shen
    Academic press:
    PLOS Computational Biology (rok: 2022, tom: 18, strony: 12785), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1009811 - link to the publication
  11. Non-self RNA rewires IFNβ signaling: A mathematical model of the innate immune response
    Authors:
    Zbigniew Korwek, Maciej Czerkies, Joanna Jaruszewicz-Błońska , Wiktor Prus , Ilona Kosiuk , Marek Kochańczyk, and Tomasz Lipniacki
    Academic press:
    Science Signaling , Wydawca: AAAS
    Status:
    Submitted
    DOI:
    link to the publication
  12. Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts
    Authors:
    Robert C. Mines, Tomasz Lipniacki, Xiling Shen
    Academic press:
    PLOS Computational Biology (rok: 2022, tom: 18, strony: 12785), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1009811 - link to the publication
  13. Non-self RNA rewires IFNβ signaling: A mathematical model of the innate immune response
    Authors:
    Zbigniew Korwek, Maciej Czerkies, Joanna Jaruszewicz-Błońska , Wiktor Prus , Ilona Kosiuk , Marek Kochańczyk, and Tomasz Lipniacki
    Academic press:
    Science Signaling (rok: 2023, tom: 165, strony: 815), Wydawca: AAAS
    Status:
    Published
    DOI:
    link to the publication
  14. Impaired O2 unloading from stored blood results in diffusion-limited O2 release at tissues: evidence from human kidneys
    Authors:
    Richard Dumbill, Julija Rabcuka, John Fallon, Simon Knight, James Hunter, Daniel Voyce, Jacob Barrett, Matt Ellen, Annemarie Weissenbacher, Tetuko Kurniawan, Slawomir Blonski, Piotr Michal Korczyk, Rutger Ploeg, Constantin Coussios, Peter Friend, Pawel Swietach
    Academic press:
    Blood (rok: 2024, tom: 143, strony: 721-733), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/blood.2023022385 - link to the publication
  15. Prototyping in Polymethylpentene to Enable Oxygen-Permeable On-a-Chip Cell Culture and Organ-on-a-Chip Devices Suitable for Microscopy
    Authors:
    Linda Sønstevold, Paulina Koza, Maciej Czerkies, Erik Andreassen, Paul McMahon, Elizaveta Vereshchagina
    Academic press:
    Micromachines (rok: 2024, tom: 15, strony: 898), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/mi15070898 - link to the publication
  16. Antagonism between viral infection and innate immunity at the single-cell level
    Authors:
    Frederic Grabowski, Marek Kochańczyk, Zbigniew Korwek, Maciej Czerkies, Wiktor Prus, Tomasz Lipniacki
    Academic press:
    PLOS Pathogens (rok: 2023, tom: b.d., strony: b.d.), Wydawca: b.d.
    Status:
    Submitted
    DOI:
    link to the publication
  17. Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts
    Authors:
    Robert C. Mines, Tomasz Lipniacki, Xiling Shen
    Academic press:
    PLOS Computational Biology (rok: 2022, tom: 18, strony: 12785), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1009811 - link to the publication
  18. The Spread of SARS-CoV-2 Variant Omicron with a Doubling Time of 2.0–3.3 Days Can Be Explained by Immune Evasion
    Authors:
    Marek Kochanczyk, Frederic Grabowski, Tomasz Lipniacki
    Academic press:
    Viruses (rok: 2022, tom: 14, strony: 294), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v14020294 - link to the publication
  19. Antagonism between viral infection and innate immunity at the single-cell level
    Authors:
    Frederic Grabowski, Marek Kochańczyk, Zbigniew Korwek, Maciej Czerkies, Wiktor Prus, Tomasz Lipniacki
    Academic press:
    PLOS Pathogens (rok: 2023, tom: 19, strony: b.d.), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1011597 - link to the publication
  20. SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations
    Authors:
    Frederic Grabowski, Grzegorz Preibisch, Stanisław Giziński, Marek Kochanczyk, Tomasz Lipniacki
    Academic press:
    Viruses (rok: 2021, tom: 13, strony: 392), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v13030392 - link to the publication
  21. SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations
    Authors:
    Frederic Grabowski, Grzegorz Preibisch, Stanisław Giziński, Marek Kochanczyk, Tomasz Lipniacki
    Academic press:
    Viruses (rok: 2021, tom: 13, strony: 392), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v13030392 - link to the publication
  22. Respiratory syncytial virus protects bystander cells against influenza A virus infection by triggering secretion of type I and type III interferons
    Authors:
    Maciej Czerkies, Marek Kochańczyk, Zbigniew Korwek, Wiktor Prus, Tomasz Lipniacki
    Academic press:
    Journal of Virology (rok: 2022, tom: 96, strony: e01341-22), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/jvi.01341-22 - link to the publication
  23. A plausible identifiable model of the canonical NF-κB signaling pathway
    Authors:
    Joanna Jaruszewicz-Błońska, Ilona Kosiuk, Wiktor Prus, Tomasz Lipniacki
    Academic press:
    PLOS One (rok: 2023, tom: b.d., strony: b.d.), Wydawca: Public Library of Science
    Status:
    Submitted
    DOI:
    link to the publication
  24. Non-self RNA rewires IFNβ signaling: A mathematical model of the innate immune response
    Authors:
    Zbigniew Korwek, Maciej Czerkies, Joanna Jaruszewicz-Błońska , Wiktor Prus , Ilona Kosiuk , Marek Kochańczyk, and Tomasz Lipniacki
    Academic press:
    Science Signaling , Wydawca: AAAS
    Status:
    Submitted
    DOI:
    link to the publication

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