Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Novel mechanisms of PAD activity regulation. Substrate specificity and activation of peptidyl arginine deiminase in the context of rheumatoid arthritis.

2019/34/H/NZ1/00674

Keywords:

citrulline citrullination deiminase activation calcium heparin glycosaminoglycans GAG

Descriptors:

  • NZ1_002:
  • NZ6_001:
  • ST4_009:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Tomasz Kantyka 

Number of co-investigators in the project: 8

Call: GRIEG 1 - announced on 2019-06-17

Amount awarded: 6 125 205 PLN

Project start date (Y-m-d): 2021-12-17

Project end date (Y-m-d): 2024-04-16

Project duration:: 28 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Ursolic Acid Formulations Effectively Induce Apoptosis and Limit Inflammation in the Psoriasis Models In Vitro
    Authors:
    Ewa Bielecka, Natalia Zubrzycka, Karolina Marzec, Anna Maksylewicz, Maja Sochalska, Agnieszka Kulawik-Pióro, Elwira Lasoń, Karolina Śliwa, Magdalena Malinowska, Elżbieta Sikora, Krzysztof Nowak, Małgorzata Miastkowska and Tomasz Kantyka
    Academic press:
    Biomedicines (rok: 2024, tom: 12(4), 732, strony: 45683), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines12040732 - link to the publication
  2. Identification of a new genetic variant (G231N, E232T, N235D) of peptidylarginine deiminase from P. gingivalis in advanced periodontitis
    Authors:
    Grzegorz P. Bereta, Karolina Strzelec, Katarzyna Łazarz-Bartyzel, Agata Dziedzic-Kowalska, Zuzanna Nowakowska, Anna Krutyhołowa, Ewa Bielecka,Tomasz Kantyka, Aleksander M. Grabiec,Tomasz Kaczmarzyk, Maria Chomyszyn-Gajewska,Jan Potempa and Katarzyna Gawron
    Academic press:
    Frontiers in Immunology (rok: 2024, tom: 15 - 2024, strony: 15:1355357), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2024.1355357 - link to the publication
  3. SARS-CoV-2 Mpro oligomerization as a potential target for therapy
    Authors:
    Kinga Lis, Jacek Plewka, Filipe Menezes, Ewa Bielecka, Yuliya Chykunova, Katarzyna Pustelny, Stephan Niebling, Angelica Struve Garcia, Maria Garcia-Alai, Grzegorz M. Popowicz, Anna Czarna, Tomasz Kantyka, Krzysztof Pyrc
    Academic press:
    International Journal of Biological Macromolecules (rok: 2024, tom: 267 (2024) 131392, strony: 45669), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2024.131392 - link to the publication

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