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Light-regulated mitochondrial potassium channels:searching for new cytoprotective mechanisms?

2019/34/A/NZ1/00352

Keywords:

mitochondria cytoprotection potassium channels infrared light

Descriptors:

  • NZ1_002:
  • NZ1_003:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Adam Michał Szewczyk 

Number of co-investigators in the project: 6

Call: MAESTRO 11 - announced on 2019-06-17

Amount awarded: 4 006 400 PLN

Project start date (Y-m-d): 2020-04-23

Project end date (Y-m-d): 2026-04-22

Project duration:: 72 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (26)
  1. Redox Regulation of Mitochondrial Potassium Channels Activity Antioxidants.
    Authors:
    Lewandowska, J., Kalenik, B., Wrzosek, A., Szewczyk, A.
    Academic press:
    Antioxidants (rok: 2024, tom: 13, strony: 434), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox13040434 - link to the publication
  2. Understanding mitochondrial potassium channels: 33 years after discovery.
    Authors:
    Szewczyk, A.
    Academic press:
    Acta Biochimica Polonica (rok: 2024, tom: 71, strony: 13126), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/abp.2024.13126 - link to the publication
  3. Current Challenges of Mitochondrial Potassium Channel Research
    Authors:
    Bogusz Kulawiak and Adam Szewczyk
    Academic press:
    Frontiers in Physiology (rok: 2022, tom: 13, strony: 46033), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphys.2022.907015 - link to the publication
  4. Loss of the large conductance calcium-activated potassium channel causes an increase in mitochondrial reactive oxygen species in glioblastoma cells.
    Authors:
    Kulawiak, B., Zochowska, M., Bednarczyk, P., Galuba, A., Stroud, D.A., and Szewczyk, A.
    Academic press:
    Pflügers Archiv - European Journal of Physiology (rok: 2023, tom: 475, strony: 1045–1060), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00424-023-02833-9 - link to the publication
  5. Lack of activity of the mitochondrial large-conductance calcium-regulated potassium channels in senescent vascular smooth muscle cells
    Authors:
    Agata Głuchowska, Barbara Kalenik , Bogusz Kulawiak, Antoni Wrzosek, Adam Szewczyk, Piotr Bednarczyk, Grażyna Mosieniak
    Academic press:
    Mechanisms of Ageing and Development (rok: 2023, tom: 215, strony: 111871), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mad.2023.111871 - link to the publication
  6. mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming
    Authors:
    Helmut BischofSelina MaierPiotr KoprowskiBogusz KulawiakSandra BurgstallerJoanna JasińskaKristian SerafimovMonika ZochowskaDominic GrossWerner SchrothLucas MattDavid Arturo Juarez LopezYing ZhangIrina BonzheimFlorian A BüttnerFalko FendMatthias SchwabAndreas L BirkenfeldRoland MalliMichael LämmerhoferPiotr BednarczykAdam SzewczykRobert Lukowski
    Academic press:
    eLife (rok: 2024, tom: 12, strony: RP92511), Wydawca: eLife
    Status:
    Published
    DOI:
    10.7554/eLife.92511 - link to the publication
  7. Single channel properties of mitochondrial large conductance potassium channel formed by BK-VEDEC splice variant.
    Authors:
    Shur Gałecka, Bogusz Kulawiak, Piotr Bednarczyk, Harpreet Singh, Adam Szewczyk
    Academic press:
    Scientific Report (rok: 2021, tom: 11, strony: 10925), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-90465-3 - link to the publication
  8. Mitochondrial Ion Channels
    Authors:
    Ildiko Szabo and Adam Szewczyk
    Academic press:
    Annual Review of Biophysics (rok: 2023, tom: 52, strony: 229–54), Wydawca: Annual Reviews
    Status:
    Published
    DOI:
    10.1146/annurev-biophys-092622- - link to the publication
  9. Molecular and functional effects of loss of cytochrome c oxidase subunit 8A
    Authors:
    Daria Rotko, Alexei P. Kudin, Gabor Zsurka, Bogusz Kulawiak, Adam Szewczyk, Wolfram S. Kunz
    Academic press:
    Biochemistry (Moscow) (rok: 2021, tom: 86, strony: 33-43), Wydawca: Pleiades Publishing Ltd
    Status:
    Published
    DOI:
    10.1134/S0006297921010041 - link to the publication
  10. Multidimensional regulation of cardiac mitochondrial potassium channels
    Authors:
    Bogusz Kulawiak, Piotr Bednarczyk, Adam Szewczyk
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1554), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061554 - link to the publication
  11. Methods of Measuring Mitochondrial Potassium Channels: A Critical Assessment
    Authors:
    Walewska, A.; Krajewska, M.; Stefanowska, A.; Buta, A.; Bilewicz, R.; Krysiński, P.; Bednarczyk, P.; Koprowski, P.; Szewczyk, A
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1210), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031210 - link to the publication
  1. MITOCHONDRIAL POTASSIUM CHANNELS AND CARDIOPROTECTION
    Authors:
    Adam Szewczyk
    Conference:
    Program and Abstract Book (rok: 2023, tom: Jędrzej Sniadecki Memorial Conference Frontiers in Molecular Life Sciences (JSMC-2023) Vilnius, Lithuania, strony: 11), Wydawca: Lithuanian Biochemical Society
    Data:
    konferencja 23-25 maj
    Status:
    Published
  2. Characterisation of potassium channels in guinea pig cardiomyocytes
    Authors:
    J. Jasińska, P. Bednarczyk, B. Kalenik , B. Kulawiak, A. Wrzosek , A. Szewczyk
    Conference:
    The Biochemistry Global Summit (rok: 2022, tom: The Biochemistry Global Summit, 25th IUBMB Congress, 46th FEBS Congress, 15th PABMB Congress, July 9–14, 2022, Lisbon, Portugal, strony: 150, P­-01.4-­015), Wydawca: FEBS
    Data:
    konferencja July 9–14, 2022
    Status:
    Published
    DOI:
    10.1002/2211-5463.13440 - link to the publication
  3. Straight from the heart – infrared light regulation of mitochondrial large conductance Ca2+-activated potassium channel activity in cardiomyocytes of Guinea Pig
    Authors:
    Joanna Lewandowska, Piotr Bednarczyk, Barbara Kalenik, Bogusz Kulawiak, Antoni Wrzosek, Adam Szewczyk
    Conference:
    EBEC2024 Abstract Book (rok: 2024, tom: EBEC2024 Abstract Book, strony: 84), Wydawca: Elsevier
    Data:
    konferencja 26-31 August 2024
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2024.149329 - link to the publication
  4. Redox and light modulation of mitochondrial large conductance Ca2+-activated potassium channel
    Authors:
    Joanna Lewandowska
    Conference:
    Konferencja Doktorantów 8th International PhD Student Conference, 8-9.10.2024 (rok: 2024, tom: 8 Międzynarodowa Konferencja Doktorantów, strony: 14), Wydawca: Materiały zjazdowe
    Data:
    konferencja 2024-10-08 — 2024-10-09
    Status:
    Published
    DOI:
    link to the publication
  5. Light modulation of mitochondrial potassium channels activity isolated from Guinea Pig cardiomyocytes.
    Authors:
    Antoni Wrzosek, Joanna Lewandowska, Barbara Kalenik, Piotr Bednarczyk, Adam Szewczyk
    Conference:
    29th Kraków Conference on Endothelium (rok: 2024, tom: 29th Kraków Conference on Endothelium, strony: 85), Wydawca: Materiały zjazdowe
    Data:
    konferencja 25-27 DSeptember 2024
    Status:
    Published
  6. RNA sequencing analysis of transcriptome changes upon mtDNA depletion with the focus on potassium ion channels.
    Authors:
    Daria Rotko, Bogusz Kulawiak, Adam Szewczyk, Wolfram S. Kunz
    Conference:
    9th MITOCHONDRION 2021 (rok: 2021, tom: 9th MITOCHONDRION 2021, strony: 32), Wydawca: Sekcja Bioenergetyki Polskiego Towarzystwa Biochemicznego
    Data:
    konferencja 27.01.2021
    Status:
    Published
  7. LOSS OF THE BKCA CHANNEL CAUSES AN INCREASE IN MITOCHONDRIAL REACTIVE OXYGEN SPECIES IN GLIOBLASTOMA CELLS
    Authors:
    Bogusz Kulawiak, Monika Żochowska, Piotr Bednarczyk, Andrzej Galuba, Adam Szewczyk
    Conference:
    The Program and Abstract Book (rok: 2023, tom: Jędrzej Sniadecki Memorial Conference Frontiers in Molecular Life Sciences (JSMC-2023) Vilnius, strony: 79), Wydawca: Lethuanian Biochemical Society
    Data:
    konferencja May 23-25
    Status:
    Published
  8. Modulation of mitochondrial large conductance potassium channels activity by infrared light
    Authors:
    Jasińska Joanna, Bednarczyk P, Kalenik B, Kulawiak B, Wrzosek A, Szewczyk A
    Conference:
    Bioenerg Commun 2023.2 (rok: 2023, tom: MiPschool and MiPconference 2023, strony: 26), Wydawca: Bioenergetics Communications
    Data:
    konferencja 23-30 July
    Status:
    Published
    DOI:
    10.26124/bec:2023-0002 - link to the publication
  9. Loss of BKCa channel leads to change of mitochondrial redox homeostasis in glioma cells
    Authors:
    Monika Żochowska, Andrzej Galuba, Piotr Bednarczyk, David A. Stroud, Adam Szewczyk, Bogusz Kulawiak
    Conference:
    the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences (rok: 2023, tom: the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences, strony: 24, 6/7), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13-16 września
    Status:
    Published
    DOI:
    link to the publication
  10. Mitochondrial potassium channels: new properties and functions
    Authors:
    Szewczyk, A.
    Conference:
    EBEC2024 Abstract Book (rok: 2024, tom: 22nd European Bioenergetics Conference, strony: 34), Wydawca: Elsevier
    Data:
    konferencja 26-31 August 2024
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2024.149192 - link to the publication
  11. FUNCTIONAL IMAGING OF CELLULAR DYNAMICS
    Authors:
    Barbara Kalenik
    Conference:
    FUNCTIONAL IMAGING OF CELLULAR DYNAMICS (rok: 2024, tom: FEBS Advanced Course, FUNCTIONAL IMAGING OF CELLULAR DYNAMICS, strony: 0), Wydawca: Materiały zjazdowe
    Data:
    konferencja 09-15 June 2024
    Status:
    Published
    DOI:
    link to the publication
  12. Mitochondrial BKCa channels in senescent vascular smooth muscle cells
    Authors:
    Adam Szewczyk
    Conference:
    Journal of Mitochondria, Plastids and Endosymbiosis (rok: 2023, tom: 14th World Congress on Targeting Mitochondria, strony: 82), Wydawca: UK Limited trading as Taylor & Francis Group on behalf of the World Mitochondria Society.
    Data:
    konferencja October 11-13
    Status:
    Published
    DOI:
    10.1080/28347056.2023.2270281 - link to the publication
  13. The relationship between the mitochondrial BKCa channel and the cellular redox state.
    Authors:
    Bogusz Kulawiak, Shur Gałecka, Karolina Pytlak, Kamila Maliszewska-Olejniczak, Piotr Bednarczyk, Monika Żochowska, Antoni Wrzosek, Adam Szewczyk
    Conference:
    29th Kraków Conference on Endothelium (rok: 2024, tom: 29th Kraków Conference on Endothelium, strony: 59), Wydawca: Materiały zjazdowe
    Data:
    konferencja 25-27 DSeptember 2024
    Status:
    Published
  14. Does infrared light regulate activity of mitochondrial large conductance potassium channel?
    Authors:
    Joanna Jasińska, Piotr Bednarczyk, Barbara Kalenik, Bogusz Kulawiak, Antoni Wrzosek, Adam Szewczyk
    Conference:
    Book and Abstract (rok: 2023, tom: LW 10th MITOCHONDRION Meeting 2023, strony: 1), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja June 20th-21st 2023
    Status:
    Published
    DOI:
    link to the publication
  15. Potassium ions traffic in mitochondria
    Authors:
    Bogusz Kulawiak, Shur Gałecka, Piotr Bednarczyk, Monika Żochowska, Antoni Wrzosek, Adam Szewczyk
    Conference:
    the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences (rok: 2023, tom: the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences, strony: 46029), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13-16 września 2023
    Status:
    Published
    DOI:
    link to the publication
  16. Characterization of the mitochondrial large-conductance calcium-activated potassium channels in rodent cardiomyocytes
    Authors:
    Barbara Kalenik, Joanna Jasińska, Antoni Wrzosek, Bogusz Kulawiak, Piotr Bednarczyk, Adam Szewczyk
    Conference:
    the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences (rok: 2023, tom: the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences, strony: 20, 2/7), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13-16 września
    Status:
    Published
    DOI:
    link to the publication
  17. Mitochondrial BK channels in senescent vascular smooth muscle cells.
    Authors:
    Szewczyk, A.
    Conference:
    Biophysical Journal ,Volume 123, Issue 3, Supplement 1, 8 February 2024, Page 523a, 2914-Pos (rok: 2024, tom: Biophysical Society 68th Annual Meeting, February 10-14, 2024 Philadelphia, PA, strony: 523a, 2914-Pos), Wydawca: Elsevier
    Data:
    konferencja 10-14 luty 2024
    Status:
    Published
    DOI:
    10.1016/j.bpj.2023.11.3163 - link to the publication
  18. Decrease of mitochondrial BKCa channel activity caused by H2O2 induced senescence in human vascular smooth muscle cells
    Authors:
    Antoni Wrzosek, Barbara Kalenik, Agata Głuchowska, Bogusz Kulawiak, Piotr Bednarczyk, Grażyna Mosieniak, Adam Szewczyk
    Conference:
    Book of Abstracts (rok: 2023, tom: LW 10th MITOCHONDRION Meeting 2023, strony: 22), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja June 20th-21st 2023
    Status:
    Published
    DOI:
    link to the publication
  19. Mitochondrial potassium channels protect senescent aortal smooth muscle cells from exceed ROS synthesis?
    Authors:
    B. Kalenik, A. Głuchowska, A. Wrzosek, B. Kulawiak, P. Bednarczyk, G. Mosieniak, A. Szewczyk
    Conference:
    PROGRAMME AND ABSTRACT BOOK (rok: 2023, tom: 1st FEBS REDOX MEDICINE WORKSHOP FROM CELLULAR SIGNALING TO SYSTEMS PHYSIOLOGY AND THERAPEUTIC TARGETS, strony: 51), Wydawca: FEBS
    Data:
    konferencja May 22 – 25, 2023
    Status:
    Published
    DOI:
    link to the publication
  20. Loss of the BKCa channel causes an increase in mitochondrial reactive oxygen species in glioblastoma cells
    Authors:
    Bogusz Kulawiak, Monika Żochowska, Piotr Bednarczyk, David Stroud, Andrzej Galuba, Adam Szewczyk
    Conference:
    Book of Abstracts (rok: 2023, tom: LW 10th MITOCHONDRION Meeting 2023, strony: 15), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja June 20th-21st 2023
    Status:
    Published
  21. Mitochondrial BKCa channels in senescent vascular smooth muscle cells
    Authors:
    Antoni Wrzosek, Barbara Kalenik, Agata Głuchowska, Bogusz Kulawiak, Piotr Bednarczyk, Grażyna Mosieniak, Adam Szewczyk
    Conference:
    the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences (rok: 2023, tom: the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences, strony: 23, 5/7), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13-16 września
    Status:
    Published
    DOI:
    link to the publication
  22. Loss of the BKCa channel causes an increase in mitochondrial reactive oxygen species in glioblastoma cells
    Authors:
    Bogusz Kulawiak, Monika Zochowska, Piotr Bednarczyk, David Stroud, Andrzej Galuba, Adam Szewczyk
    Conference:
    the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences (rok: 2023, tom: the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences, strony: 15), Wydawca: Polskie Towarzysytwo Biochemiczne
    Data:
    konferencja 13-16 września 2023
    Status:
    Published
    DOI:
    link to the publication
  23. IMPAIRMENT OF MITOCHONDRIAL BKCA CHANNEL ACTIVITY CAUSED BY INDUCTION OF SENESCENCE IN VASCULAR SMOOTH MUSCLE CELLS
    Authors:
    Antoni Wrzosek, Barbara Kalenik, Agata Głuchowska, Bogusz Kulawiak, Piotr Bednarczyk, Grażyna Mosieniak, Adam Szewczyk
    Conference:
    The Program and Abstract Book (rok: 2023, tom: Jędrzej Sniadecki Memorial Conference Frontiers in Molecular Life Sciences, strony: 43), Wydawca: Lithuanian Biochemical Society
    Data:
    konferencja May 23-25, 2023
    Status:
    Published
  24. Are mitochondrial BKCa channels present and active in senescent vascular smooth muscle cells?
    Authors:
    Barbara Kalenik, Agata Głuchowska, Antoni Wrzosek, Bogusz Kulawiak, Piotr Bednarczyk, Grażyna Mosieniak, Adam Szewczyk
    Conference:
    Book of Abstract (rok: 2023, tom: LW 10th MITOCHONDRION Meeting 2023, strony: 5), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja June 20th-21st 2023
    Status:
    Published
    DOI:
    link to the publication
  25. The role of infrared light in modulation of mitochondrial large-conductance calcium-activated potassium channel
    Authors:
    Joanna Jasińska, Piotr Bednarczyk, Barbara Kalenik, Bogusz Kulawiak, Antoni Wrzosek, Adam Szewczyk
    Conference:
    the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences (rok: 2023, tom: the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences, strony: 76, 5/5), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13-16 września
    Status:
    Published
    DOI:
    link to the publication
  26. Are mitochondrial BKCa channels present and active in senescent vascular smooth muscle cells?
    Authors:
    Barbara Kalenik, Agata Głuchowska, Antoni Wrzosek, Bogusz Kulawiak, Piotr Bednarczyk, Grażyna Mosieniak, Adam Szewczyk
    Conference:
    the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences (rok: 2023, tom: the 5th Congress of Polish Biosciences BIO2023 Different faces of biosciences, strony: 5), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13-16 września 2023
    Status:
    Published
    DOI:
    link to the publication

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