Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Revealing sources of cell-to-cell heterogeneity in interferon gamma responses

2019/33/N/NZ2/02691

Keywords:

interferon gamma heterogeneity signaling pathway fibroblasts cell cycle circadian clock syncytium ordinary differential equations

Descriptors:

  • NZ2_009:
  • NZ2_010:
  • NZ3_007:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Piotr Topolewski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 17 - announced on 2019-03-15

Amount awarded: 140 000 PLN

Project start date (Y-m-d): 2020-02-05

Project end date (Y-m-d): 2022-02-04

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Phenotypic variability, not noise, accounts for most of the cell-to-cell heterogeneity in IFN-γ and oncostatin M signaling responses
    Authors:
    Topolewski, P., Zakrzewska, K.E., Walczak, J., Nienałtowski, K., Müller-Newen, G., Singh, A., Komorowski, M.
    Academic press:
    Science Signaling (rok: 2022, tom: 15 (721), strony: eabd9303), Wydawca: American Association for the Advancement of Science (AAAS)
    Status:
    Published
    DOI:
    10.1126/scisignal.abd9303 - link to the publication
  2. Information-theoretic analyses of cellular strategies for achieving high signaling capacity — dynamics, cross-wiring and heterogeneity of cellular states
    Authors:
    Piotr Topolewski, Michał Komorowski
    Academic press:
    Current Opinion in Systems Biology (rok: 2021, tom: 27, strony: 100352), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.coisb.2021.06.003 - link to the publication