Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Mammalian cell delivery of stable therapeutic mRNA packaged inside virus-like particles.

2019/33/B/NZ6/01241

Keywords:

mRNA virus-like particles vaccines cell delivery immunological response

Descriptors:

  • NZ6_005:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bogusław Szewczyk 

Number of co-investigators in the project: 7

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 2 294 640 PLN

Project start date (Y-m-d): 2020-02-20

Project end date (Y-m-d): 2025-08-19

Project duration:: 66 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Trinucleotide cap analogs with triphosphate chain modifications: synthesis, properties, and evaluation as mRNA capping reagents
    Authors:
    M. Warminski, A. Depaix, K. Ziemkiewicz, T. Spiewla, J. Zuberek, K. Drazkowska, H. Kedzierska, A. Popielec, M. R. Baranowski, M. Sklucka, M. Bednarczyk, M. Smietanski, K. Wolosewicz, B. Majewski, R. A. Serwa, D. Nowis, J. Golab, J. Kowalska, J. Jemielity
    Academic press:
    Nucleic Acids Research (rok: 2024, tom: 52, strony: 10788–10809), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkae763 - link to the publication
  2. Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs
    Authors:
    Gromadzka B., Chraniuk M., Hovhannisyan L., Uranowska, K., Szewczyk, B., Narajczyk, M., Panasiuk, M.
    Academic press:
    Viruses (rok: 2022, tom: 14, strony: 730), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v14040730 - link to the publication
  3. Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs
    Authors:
    Gromadzka B., Chraniuk M., Hovhannisyan L., Uranowska, K., Szewczyk, B., Narajczyk, M., Panasiuk, M.
    Academic press:
    Viruses (rok: 2022, tom: 14, strony: 730), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v14040730 - link to the publication
  4. Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs
    Authors:
    Gromadzka B., Chraniuk M., Hovhannisyan L., Uranowska, K., Szewczyk, B., Narajczyk, M., Panasiuk, M.
    Academic press:
    Viruses (rok: 2022, tom: 14, strony: 730), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v14040730 - link to the publication
  5. Serological characterisation of Lagovirus virus-like particles originating from native and mutated VP60 of rabbit haemorrhagic disease virus 2 and European brown hare syndrome virus
    Authors:
    Martyna Krejmer-Rąbalska, Marta Peplińska, Bogusław Szewczyk, Andrzej Fitzner
    Academic press:
    Journal of Veterinary Research (rok: 2024, tom: 68, strony: 45917), Wydawca: Sciendo
    Status:
    Published
    DOI:
    10.2478/jvetres-2024-0019 - link to the publication