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Information of the project and the call

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Preventing the accumulation of cytotoxic oligomers, that are causative agents of neurodegenerative diseases and Type 2 Diabetes, by activation of the 20S proteolytic system

2019/33/B/NZ7/00112

Keywords:

neurodegenerative diseases Type 2 Diabetes mellitus oligomer proteasome

Descriptors:

  • NZ7_012:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Elżbieta - Jankowska 

Number of co-investigators in the project: 7

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 935 800 PLN

Project start date (Y-m-d): 2020-02-06

Project end date (Y-m-d): 2024-10-05

Project duration:: 56 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. New Peptide-Based Pharmacophore Activates 20S Proteasome
    Authors:
    Paweł A. Osmulski, Przemysław Karpowicz, Elzbieta Jankowska, Jonathan Bohmann, Andrew M. Pickering, Maria Gaczynska
    Academic press:
    Molecules (rok: 2020, tom: 25, 1439, strony: 45674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25061439 - link to the publication
  2. Peptidomimetics Based on C-Terminus of Blm10 Stimulate Human 20S Proteasome Activity and Promote Degradation of Proteins
    Authors:
    Cekała K, Trepczyk K, Sowik D, Karpowicz P, Giełdon A, Witkowska J, Gizynska M, Jankowska E, Wieczerzak E.
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 777), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12060777 - link to the publication
  3. Peptidomimetics Based on C-Terminus of Blm10 Stimulate Human 20S Proteasome Activity and Promote Degradation of Proteins
    Authors:
    Cekała K, Trepczyk K, Sowik D, Karpowicz P, Giełdon A, Witkowska J, Gizynska M, Jankowska E, Wieczerzak E.
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 777), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12060777 - link to the publication
  4. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression model
    Authors:
    E. Sandra Chocron, Erin Munkácsy, Harper S. Kim, Przemyslaw Karpowicz, Nisi Jiang, Candice E. Van Skike, Nicholas DeRosa, Andy Q. Banh, Juan P. Palavicini, Paweł Wityk, Leszek Kalinowski, Veronica Galvan, Pawel A. Osmulski, Elzbieta Jankowska, Maria Gaczynska, Andrew M. Pickering
    Academic press:
    Science Advances (rok: 2022, tom: 8, strony: 45675), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/sciadv.abk2252 - link to the publication
  5. New Peptide-Based Pharmacophore Activates 20S Proteasome
    Authors:
    Paweł A. Osmulski, Przemysław Karpowicz, Elzbieta Jankowska, Jonathan Bohmann, Andrew M. Pickering, Maria Gaczynska
    Academic press:
    Molecules (rok: 2020, tom: 25, 1439, strony: 45674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25061439 - link to the publication
  6. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression model
    Authors:
    E. Sandra Chocron, Erin Munkácsy, Harper S. Kim, Przemyslaw Karpowicz, Nisi Jiang, Candice E. Van Skike, Nicholas DeRosa, Andy Q. Banh, Juan P. Palavicini, Paweł Wityk, Leszek Kalinowski, Veronica Galvan, Pawel A. Osmulski, Elzbieta Jankowska, Maria Gaczynska, Andrew M. Pickering
    Academic press:
    Science Advances (rok: 2022, tom: 8, strony: 45675), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/sciadv.abk2252 - link to the publication
  7. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression model
    Authors:
    E. Sandra Chocron, Erin Munkácsy, Harper S. Kim, Przemyslaw Karpowicz, Nisi Jiang, Candice E. Van Skike, Nicholas DeRosa, Andy Q. Banh, Juan P. Palavicini, Paweł Wityk, Leszek Kalinowski, Veronica Galvan, Pawel A. Osmulski, Elzbieta Jankowska, Maria Gaczynska, Andrew M. Pickering
    Academic press:
    Science Advances (rok: 2022, tom: 8, strony: 45675), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/sciadv.abk2252 - link to the publication
  8. New Peptide-Based Pharmacophore Activates 20S Proteasome
    Authors:
    Paweł A. Osmulski, Przemysław Karpowicz, Elzbieta Jankowska, Jonathan Bohmann, Andrew M. Pickering, Maria Gaczynska
    Academic press:
    Molecules (rok: 2020, tom: 25, 1439, strony: 45674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25061439 - link to the publication

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