Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of the oxidative stress in adoptive cell therapy with chimeric antigen receptors

2019/33/B/NZ6/02503

Keywords:

adoptive cell therapy chimeric antigen receptors T cells NK cells tumor microenvironment oxidative stress reactive oxygen species

Descriptors:

  • NZ6_002:
  • NZ6_001:
  • NZ5_007:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Agnieszka Bajor 

Number of co-investigators in the project: 5

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 890 200 PLN

Project start date (Y-m-d): 2020-03-05

Project end date (Y-m-d): 2026-02-04

Project duration:: 71 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  1. The Immune Landscape of Breast Cancer: Strategies for Overcoming Immunotherapy Resistance.
    Authors:
    Kuba Retecki, Milena Seweryn,Agnieszka Graczyk-Jarzynka and Malgorzata Bajor
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13, strony: 11689), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13236012 - link to the publication
  2. PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells
    Authors:
    Bajor, M., Graczyk-Jarzynka, A., Marhelava, K., Burdzinska, A., Muchowicz, A., Goral, A., Zhylko, A., Soroczynska, K., Retecki, K., Krawczyk, M., Klopotowska, M., Pilch, Z., Paczek, L., Malmberg, K. J., Wälchli, S., Winiarska M., & Zagozdzon, R.
    Academic press:
    Journal for immunotherapy of cancer (rok: 2022, tom: 10(1), strony: 45671), Wydawca: BMJ
    Status:
    Published
    DOI:
    10.1136/jitc-2021-002500 - link to the publication
  3. PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells
    Authors:
    Bajor, M., Graczyk-Jarzynka, A., Marhelava, K., Burdzinska, A., Muchowicz, A., Goral, A., Zhylko, A., Soroczynska, K., Retecki, K., Krawczyk, M., Klopotowska, M., Pilch, Z., Paczek, L., Malmberg, K. J., Wälchli, S., Winiarska M., & Zagozdzon, R.
    Academic press:
    Journal for immunotherapy of cancer (rok: 2022, tom: 10(1), strony: 45671), Wydawca: BMJ
    Status:
    Published
    DOI:
    10.1136/jitc-2021-002500 - link to the publication
  4. The Immune Landscape of Breast Cancer: Strategies for Overcoming Immunotherapy Resistance.
    Authors:
    Kuba Retecki, Milena Seweryn,Agnieszka Graczyk-Jarzynka and Malgorzata Bajor
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13, strony: 11689), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13236012 - link to the publication
  5. The Immune Landscape of Breast Cancer: Strategies for Overcoming Immunotherapy Resistance.
    Authors:
    Kuba Retecki, Milena Seweryn,Agnieszka Graczyk-Jarzynka and Malgorzata Bajor
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13, strony: 11689), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13236012 - link to the publication
  6. PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
    Authors:
    Marta Klopotowska, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Agnieszka Kraft, Zofia Pilch, Andriy Zhylko, Malgorzata Firczuk, Iwona Baranowska, Michal Lazniewski, Dariusz Plewczynski, Agnieszka Goral, Karolina Soroczynska, Joanna Domagala, Katsiaryna Marhelava, Aleksander Slusarczyk, Kuba Retecki, Kavita Ramji, Marta Krawczyk, Madison N. Temples, Blanka Sharma, Mieszko Lachota, Herman Netskar, Karl-Johan Malmberg, Radoslaw Zagozdzon, Magdalena Winiarska
    Academic press:
    Cancer Immunology Research (rok: 2021, tom: 10, strony: 228–244), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/2326-6066.CIR-20-1023 - link to the publication
  7. PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
    Authors:
    Marta Klopotowska, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Agnieszka Kraft, Zofia Pilch, Andriy Zhylko, Malgorzata Firczuk, Iwona Baranowska, Michal Lazniewski, Dariusz Plewczynski, Agnieszka Goral, Karolina Soroczynska, Joanna Domagala, Katsiaryna Marhelava, Aleksander Slusarczyk, Kuba Retecki, Kavita Ramji, Marta Krawczyk, Madison N. Temples, Blanka Sharma, Mieszko Lachota, Herman Netskar, Karl-Johan Malmberg, Radoslaw Zagozdzon, Magdalena Winiarska
    Academic press:
    Cancer Immunology Research (rok: 2021, tom: 10, strony: 228–244), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/2326-6066.CIR-20-1023 - link to the publication
  8. The Immune Landscape of Breast Cancer: Strategies for Overcoming Immunotherapy Resistance.
    Authors:
    Kuba Retecki, Milena Seweryn,Agnieszka Graczyk-Jarzynka and Malgorzata Bajor
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13, strony: 11689), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13236012 - link to the publication
  9. PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
    Authors:
    Marta Klopotowska, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Agnieszka Kraft, Zofia Pilch, Andriy Zhylko, Malgorzata Firczuk, Iwona Baranowska, Michal Lazniewski, Dariusz Plewczynski, Agnieszka Goral, Karolina Soroczynska, Joanna Domagala, Katsiaryna Marhelava, Aleksander Slusarczyk, Kuba Retecki, Kavita Ramji, Marta Krawczyk, Madison N. Temples, Blanka Sharma, Mieszko Lachota, Herman Netskar, Karl-Johan Malmberg, Radoslaw Zagozdzon, Magdalena Winiarska
    Academic press:
    Cancer Immunology Research (rok: 2021, tom: 10, strony: 228–244), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/2326-6066.CIR-20-1023 - link to the publication
  10. PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells
    Authors:
    Bajor, M., Graczyk-Jarzynka, A., Marhelava, K., Burdzinska, A., Muchowicz, A., Goral, A., Zhylko, A., Soroczynska, K., Retecki, K., Krawczyk, M., Klopotowska, M., Pilch, Z., Paczek, L., Malmberg, K. J., Wälchli, S., Winiarska M., & Zagozdzon, R.
    Academic press:
    Journal for immunotherapy of cancer (rok: 2022, tom: 10(1), strony: 45671), Wydawca: BMJ
    Status:
    Published
    DOI:
    10.1136/jitc-2021-002500 - link to the publication
  11. PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
    Authors:
    Marta Klopotowska, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Agnieszka Kraft, Zofia Pilch, Andriy Zhylko, Malgorzata Firczuk, Iwona Baranowska, Michal Lazniewski, Dariusz Plewczynski, Agnieszka Goral, Karolina Soroczynska, Joanna Domagala, Katsiaryna Marhelava, Aleksander Slusarczyk, Kuba Retecki, Kavita Ramji, Marta Krawczyk, Madison N. Temples, Blanka Sharma, Mieszko Lachota, Herman Netskar, Karl-Johan Malmberg, Radoslaw Zagozdzon, Magdalena Winiarska
    Academic press:
    Cancer Immunology Research (rok: 2021, tom: 10, strony: 228–244), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/2326-6066.CIR-20-1023 - link to the publication

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