Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Regulation of chromatin accessibility in the hypoxic tumour microenvironment of glioblastoma

2019/33/B/NZ1/01556

Keywords:

glioblastoma chromatin hypoxia microglia macrophages

Descriptors:

  • NZ1_001:
  • NZ1_002:
  • NZ1_011:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Leszczyńska 

Number of co-investigators in the project: 3

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 859 480 PLN

Project start date (Y-m-d): 2020-02-05

Project end date (Y-m-d): 2024-08-04

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation
    Authors:
    Katarzyna B. Leszczynska, Monika Dzwigonska, Hala Estephan, Jutta Moehlenbrink, Elizabeth Bowler, Amato J. Giaccia, Jakub Mieczkowski, Bozena Kaminska and Ester M. Hammond
    Academic press:
    Molecular Oncology (rok: 2023, tom: 2023 Apr 4 online ahead of print, strony: 45676), Wydawca: Wiley on behalf of the Federation of European Biochemical Societies
    Status:
    Published
    DOI:
    10.1002/1878-0261.13431 - link to the publication
  2. Emerging Advances in Combinatorial Treatments of Epigenetically Altered Pediatric High-Grade H3K27M Gliomas
    Authors:
    Katarzyna B Leszczynska, Chinchu Jayaprakash, Bozena Kaminska, Jakub Mieczkowski
    Academic press:
    Frontiers in Genetics (rok: 2021, tom: 12, strony: 45668), Wydawca: Frontiers in Genetics
    Status:
    Published
    DOI:
    10.3389/fgene.2021.742561 - link to the publication
  3. H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells
    Authors:
    Katarzyna B. Leszczynska, Amanda Freitas-Huhtamäki, Chinchu Jayaprakash, Monika Dzwigonska, Francisca N.L. Vitorino, Cynthia Horth, Kamil Wojnicki, Bartlomiej Gielniewski, Paulina Szadkowska, Beata Kaza, Javad Nazarian, Maciej K. Ciolkowski, Joanna Trubicka, Wieslawa Grajkowska, Benjamin A. Garcia, Jacek Majewski, Bozena Kaminska, Jakub Mieczkowski
    Academic press:
    Cell Reports (rok: 2024, tom: Volume 43, Issue 2, strony: 45679), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2024.113707 - link to the publication
  1. OTME-2. Regulation of chromatin accessibility in the hypoxic tumor microenvironment of glioblastoma
    Authors:
    Monika Dzwigonska, Jakub Mieczkowski, Paulina Pilanc, Salwador Cyranowski, Agata Kominek, Katarzyna Piwocka, Bozena Kaminska, Katarzyna B Leszczynska
    Conference:
    Neuro-Oncology Advances (rok: 2021, tom: Basic and Translational Scie.., strony: Volume 3, Issue Supplement_2, July 2021, Page ii13), Wydawca: Oxford Academic
    Data:
    konferencja 15-16 July 2021
    Status:
    Published
    DOI:
    10.1093/noajnl/vdab070.053 - link to the publication
  2. DIPG-40. Hypoxic stress exposes epigenetic targets to enhance radiotherapy response in H3K27M-positive pediatric diffuse midline gliomas
    Authors:
    Amanda Pereira de Freitas, Monika Dzwigonska, Joanna Trubicka, Wieslawa Grajkowska, Jakub Mieczkowski, Bozena Kaminska, Katarzyna Leszczynska
    Conference:
    Neuro-Oncology (rok: 2023, tom: 7th Biennial Pediatric Neuro-Oncology Research Conference, strony: Volume 25, Issue Supplement_1, June 2023, Page i22), Wydawca: Oxford University Press
    Data:
    konferencja June 22-24, 2023
    Status:
    Published
    DOI:
    10.1093/neuonc/noad073.087 - link to the publication

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