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Information of the project and the call

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Mechanisms of epigenetic histone modifications in hyperhomocysteinemia

2019/33/B/NZ4/01760

Keywords:

histones posttranslational modifications homocysteinylation acetylation methylation gene expression

Descriptors:

  • NZ4_011:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hieronim Jakubowski 

Number of co-investigators in the project: 7

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 2 772 800 PLN

Project start date (Y-m-d): 2020-02-18

Project end date (Y-m-d): 2025-05-17

Project duration:: 63 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (24)
  1. Homocysteine Metabolites Inhibit Autophagy and Elevate Amyloid Beta by Impairing Phf8/H4K20me1-dependent Epigenetic Regulation of mTOR in Cystathionine Beta-Synthase-Deficient Mice
    Authors:
    Lukasz Witucki, Hieronim Jakubowski
    Academic press:
    BioRxiv (rok: 2022, tom: 10, strony: 533769), Wydawca: Cold Spring Harbor Laboratory (CSHL)
    Status:
    Published
    DOI:
    10.1101/2023.03.22.533769 - link to the publication
  2. Cystathionine β-synthase gene inactivation dysregulates major urinary protein biogenesis and impairs sexual signaling in mice
    Authors:
    Ewa Bretes, Jacek Wróblewski, Monika Wyszczelska-Rokiel, Hieronim Jakubowski
    Academic press:
    BioRxiv (rok: 2022, tom: 10, strony: 499408), Wydawca: Cold Spring Harbor (CSHL)
    Status:
    Published
    DOI:
    10.499408 - link to the publication
  3. Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine β-synthase-deficient mice
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    J Inherit Metab Dis (rok: 2023, tom: 46, strony: 1114-1130), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1002/jimd.12661 - link to the publication
  4. Homocysteine Metabolites Inhibit Autophagy by Upregulating miR-21-5p, miR-155-5p, miR-216-5p, and miR-320c-3p in Human Vascular Endothelial Cells
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    Sci Rep (rok: 2024, tom: 14, strony: 7151), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-57750-3 - link to the publication
  5. The Cbs Locus Affects Expression of Senescence Markers and mtDNA Copy Number, but not Telomere Dynamics in Mice.
    Authors:
    Utyro O, Perła-Kaján J, Jakubowski H.
    Academic press:
    Int J Mol Sci (rok: 2020, tom: 21, strony: 2520), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072520 - link to the publication
  6. Cystathionine β-synthase gene inactivation dysregulates major urinary protein biogenesis and impairs sexual signaling in mice.
    Authors:
    Bretes E, Wróblewski J, Wyszczelska-Rokiel M, Jakubowski H.
    Academic press:
    FASEB Journal (rok: 2022, tom: 36, strony: e22547), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202200969R - link to the publication
  7. Proteomic Exploration of Paraoxonase 1 Function in Health and Disease
    Authors:
    Hieronim Jakubowski
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 24, strony: 7764), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24097764 - link to the publication
  8. Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory- and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease.
    Authors:
    Witucki Ł, Borowczyk K, Suszyńska-Zajczyk J, Warzych E, Pawlak E, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (rok: 2023, tom: 95, strony: 1735-1755), Wydawca: IOSpress
    Status:
    Published
    DOI:
    10.3233/JAD-230578 - link to the publication
  9. Proteome-wide analysis of protein lysine N-homocysteinylation in Saccharomyces cerevisiae.
    Authors:
    Perła-Kaján J, Malinowska A, Zimny J, Cysewski D, Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    J Proteome Res (rok: 2021, tom: 20(5), strony: 2458-2476), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jproteome.0c00937 - link to the publication
  10. Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs -/- mice and thrombosis-prone CBS -/- humans
    Authors:
    Sikora M, Lewandowska I, Marczak Ł, Bretes E, Jakubowski H.
    Academic press:
    Sci Rep (rok: 2020, tom: 10, strony: 10726), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-67672-5 - link to the publication
  11. Copper, heart disease and homocysteine thiolactone
    Authors:
    Hieronim Jakubowski
    Academic press:
    J Intern Med (rok: 2020, tom: 290, strony: 229-230), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1111/joim.13074 - link to the publication
  12. Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet.
    Authors:
    Sikora M, Jakubowski H.
    Academic press:
    Free Radic Biol Med (rok: 2021, tom: 169, strony: 169-180), Wydawca: Elsevier
    Status:
    Published
    DOI:
    0.1016/j.freeradbiomed.2021.03.042 - link to the publication
  13. The Molecular Bases of Anti-Oxidative and Anti-Inflammatory Properties of Paraoxonase 1
    Authors:
    Jakubowski H.
    Academic press:
    Antioxidants (rok: 2024, tom: 13, strony: 1292), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox13111292 - link to the publication
  14. Telomere length and mtDNA copy number in human cystathionine β-synthase deficiency
    Authors:
    Utyro O, Perła-Kaján J, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Free Radic Biol Med (rok: 2020, tom: 160, strony: 219-226), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2020.07.036 - link to the publication
  15. Homocysteine Thiolactone Detoxifying Enzymes and Alzheimer's Disease
    Authors:
    Jakubowski H.
    Academic press:
    Int J Mol Sci (rok: 2024, tom: 25, strony: 8095), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25158095 - link to the publication
  16. Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic
    Authors:
    Hieronim Jakubowski
    Academic press:
    Expert Rev Proteomics (rok: 2020, tom: 17, strony: 751-765), Wydawca: Taylor& Francis
    Status:
    Published
    DOI:
    10.1080/14789450.2020.1865160 - link to the publication
  17. Depletion of paraoxonase 1 (Pon1) dysregulates mTOR, autophagy, and accelerates amyloid beta accumulation in mice.
    Authors:
    Witucki Ł, Jakubowski H.
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 746), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12050746 - link to the publication
  18. Depletion of bleomycin hydrolase (Blmh) downregulates histone demethylase Phf8, impairs mTOR signaling/autophagy, accelerates amyloid beta accumulation, and induces neurological deficits in mice
    Authors:
    Lukasz Witucki, Kamila Borowczyk, Joanna Suszynska-Zajczyk, Ewelina Warzych, Piotr Pawlak, Hieronim Jakubowski
    Academic press:
    BioRxiv (rok: 2023, tom: 10, strony: 5335), Wydawca: Cold Spring Harbor Laboratory (CSHL)
    Status:
    Published
    DOI:
    10.1101/2023.03.20.533511 - link to the publication
  19. Anti-N-homocysteinylated protein auto-antibodies are associated with impaired cognition.
    Authors:
    Włoczkowka O, Perła-Kaján J, Smith AD, de Jager C, Refsum H, Jakubowski H.
    Academic press:
    Alzheimer's Dement (rok: 2021, tom: 7(1), strony: e12159), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1002/trc2.12159 - link to the publication
  20. Homocysteine thiolactone contributes to a prognostic value of fibrin clot structure/function in coronary artery disease.
    Authors:
    Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H.
    Academic press:
    PLOS ONE (rok: 2022, tom: 17, strony: e0275956), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0275956 - link to the publication
  21. Homocysteine thiolactone contributes to a prognostic value of fibrin clot structure/function in coronary artery disease patients
    Authors:
    Marta Sikora, Paweł Skrzydlewski, Joanna Perła-Kaján, Hieronim Jakubowski
    Academic press:
    MedRxiv (rok: 2022, tom: 2022.07.12., strony: 22277430), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2022.07.12.22277430 - link to the publication
  22. Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular Disease
    Authors:
    Jakubowski Hieronim, Witucki Łukasz
    Academic press:
    International Journal of Molecular Sciences (rok: 2025, tom: 26, strony: 746), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms26020746 - link to the publication
  23. Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice
    Authors:
    Jakubowski Hieronim, Witucki Łukasz
    Academic press:
    FASEB Journal (rok: 2024, tom: 38, strony: e70072), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202302116R - link to the publication
  24. Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans
    Authors:
    Sikora M, Bretes E, Perła-Kaján J, Lewandowska I, Marczak Ł, Jakubowski H.
    Academic press:
    Antioxidants (Basel) (rok: 2020, tom: 9(12), strony: 1198), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9121198 - link to the publication

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