Projects funded by the NCN

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Information of the project and the call

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Mechanisms of epigenetic histone modifications in hyperhomocysteinemia

2019/33/B/NZ4/01760

Keywords:

histones posttranslational modifications homocysteinylation acetylation methylation gene expression

Descriptors:

  • NZ4_011:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hieronim Jakubowski 

Number of co-investigators in the project: 7

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 2 772 800 PLN

Project start date (Y-m-d): 2020-02-18

Project end date (Y-m-d): 2025-05-17

Project duration:: 63 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (27)
  • Articles in post-conference publications (2)
  1. Copper, heart disease and homocysteine thiolactone
    Authors:
    Hieronim Jakubowski
    Academic press:
    J Intern Med (), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1111/joim.13074 - link to the publication
  2. Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    Cells , Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12050746 - link to the publication
  3. B Vitamins Prevent Iron-associated Brain Atrophy and Domain-specific Effects of Iron, Copper, Aluminum and Silicon on Cognition in Mild Cognitive Impairment
    Authors:
    Jakubowski H, Zioła-Frankowska A, Frankowski M, Perła-Kaján J, Refsum H, de Jager CA, Smith AD.
    Academic press:
    J Alzheimers Dis (tom: 84(30), strony: 1039-1055), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-215085 - link to the publication
  4. Cystathionine β-synthase gene inactivation dysregulates major urinary protein biogenesis and impairs sexual signaling in mice
    Authors:
    Ewa Bretes, Jacek Wróblewski, Monika Wyszczelska-Rokiel, Hieronim Jakubowski
    Academic press:
    BioRxiv , Wydawca: Cold Spring Harbor (CSHL)
    Status:
    Published
    DOI:
    10.499408 - link to the publication
  5. Telomere length and mtDNA copy number in human cystathionine β-synthase deficiency
    Authors:
    Utyro O, Perła-Kaján J, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Free Radic Biol Med (), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2020.07.036 - link to the publication
  6. Cystathionine β-synthase gene inactivation dysregulates major urinary protein biogenesis and impairs sexual signaling in mice.
    Authors:
    Bretes E, Wróblewski J, Wyszczelska-Rokiel M, Jakubowski H.
    Academic press:
    FASEB Journal (), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202200969R - link to the publication
  7. Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet.
    Authors:
    Sikora M, Jakubowski H.
    Academic press:
    Free Radic Biol Med (), Wydawca: Elsevier
    Status:
    Published
    DOI:
    0.1016/j.freeradbiomed.2021.03.042 - link to the publication
  8. Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans
    Authors:
    Sikora M, Bretes E, Perła-Kaján J, Lewandowska I, Marczak Ł, Jakubowski H.
    Academic press:
    Antioxidants (Basel) (tom: 9(12), strony: ), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9121198 - link to the publication
  9. Depletion of paraoxonase 1 (Pon1) dysregulates mTOR, autophagy, and accelerates amyloid beta accumulation in mice.
    Authors:
    Witucki Ł, Jakubowski H.
    Academic press:
    Cells , Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12050746 - link to the publication
  10. The Cbs Locus Affects Expression of Senescence Markers and mtDNA Copy Number, but not Telomere Dynamics in Mice.
    Authors:
    Utyro O, Perła-Kaján J, Jakubowski H.
    Academic press:
    Int J Mol Sci , Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072520 - link to the publication
  11. Homocysteine thiolactone contributes to a prognostic value of fibrin clot structure/function in coronary artery disease patients
    Authors:
    Marta Sikora, Paweł Skrzydlewski, Joanna Perła-Kaján, Hieronim Jakubowski
    Academic press:
    MedRxiv (tom: 2022.07.12., strony: ), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2022.07.12.22277430 - link to the publication
  12. Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic
    Authors:
    Hieronim Jakubowski
    Academic press:
    Expert Rev Proteomics (), Wydawca: Taylor& Francis
    Status:
    Published
    DOI:
    10.1080/14789450.2020.1865160 - link to the publication
  13. Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine β-synthase-deficient mice
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    J Inherit Metab Dis (), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1002/jimd.12661 - link to the publication
  14. Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment.
    Authors:
    Perła-Kaján J, Włoczkowka O, Zioła-Frankowska A, Frankowski M, Smith AD, de Jager C, Refsum H, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-210137 - link to the publication
  15. Anti-N-homocysteinylated protein auto-antibodies are associated with impaired cognition.
    Authors:
    Włoczkowka O, Perła-Kaján J, Smith AD, de Jager C, Refsum H, Jakubowski H.
    Academic press:
    Alzheimer's Dement (tom: 7(1), strony: e12159), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1002/trc2.12159 - link to the publication
  16. Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease
    Authors:
    Łukasz Witucki, Monika Kurpik, Hieronim Jakubowski, Michał Szulc, Przemysław Łukasz Mikołajczak, Jadwiga Jodynis-Liebert, Małgorzata Kujawska
    Academic press:
    Nutrients , Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu14102014 - link to the publication
  17. The Molecular Bases of Anti-Oxidative and Anti-Inflammatory Properties of Paraoxonase 1
    Authors:
    Jakubowski H.
    Academic press:
    Antioxidants , Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox13111292 - link to the publication
  18. Homocysteine Thiolactone Detoxifying Enzymes and Alzheimer's Disease
    Authors:
    Jakubowski H.
    Academic press:
    Int J Mol Sci , Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25158095 - link to the publication
  19. Depletion of bleomycin hydrolase (Blmh) downregulates histone demethylase Phf8, impairs mTOR signaling/autophagy, accelerates amyloid beta accumulation, and induces neurological deficits in mice
    Authors:
    Lukasz Witucki, Kamila Borowczyk, Joanna Suszynska-Zajczyk, Ewelina Warzych, Piotr Pawlak, Hieronim Jakubowski
    Academic press:
    BioRxiv , Wydawca: Cold Spring Harbor Laboratory (CSHL)
    Status:
    Published
    DOI:
    10.1101/2023.03.20.533511 - link to the publication
  20. Proteome-wide analysis of protein lysine N-homocysteinylation in Saccharomyces cerevisiae.
    Authors:
    Perła-Kaján J, Malinowska A, Zimny J, Cysewski D, Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    J Proteome Res (tom: 20(5), strony: 2458-2476), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jproteome.0c00937 - link to the publication
  21. Proteomic Exploration of Paraoxonase 1 Function in Health and Disease
    Authors:
    Hieronim Jakubowski
    Academic press:
    Int J Mol Sci , Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24097764 - link to the publication
  22. Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs -/- mice and thrombosis-prone CBS -/- humans
    Authors:
    Sikora M, Lewandowska I, Marczak Ł, Bretes E, Jakubowski H.
    Academic press:
    Sci Rep , Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-67672-5 - link to the publication
  23. Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory- and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease.
    Authors:
    Witucki Ł, Borowczyk K, Suszyńska-Zajczyk J, Warzych E, Pawlak E, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (), Wydawca: IOSpress
    Status:
    Published
    DOI:
    10.3233/JAD-230578 - link to the publication
  24. Homocysteine thiolactone contributes to a prognostic value of fibrin clot structure/function in coronary artery disease.
    Authors:
    Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H.
    Academic press:
    PLOS ONE (), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0275956 - link to the publication
  25. The Multispecies Probiotic Effectively Reduces Homocysteine Concentration in Obese Women: A Randomized Double-Blind Placebo-Controlled Study
    Authors:
    Majewska K, Kręgielska-Narożna M, Jakubowski H, Szulińska M, Bogdański P
    Academic press:
    J Clin Med (tom: 9(4), strony: ), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9040998 - link to the publication
  26. Homocysteine Metabolites Inhibit Autophagy by Upregulating miR-21-5p, miR-155-5p, miR-216-5p, and miR-320c-3p in Human Vascular Endothelial Cells
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    Sci Rep , Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-57750-3 - link to the publication
  27. Homocysteine Metabolites Inhibit Autophagy and Elevate Amyloid Beta by Impairing Phf8/H4K20me1-dependent Epigenetic Regulation of mTOR in Cystathionine Beta-Synthase-Deficient Mice
    Authors:
    Lukasz Witucki, Hieronim Jakubowski
    Academic press:
    BioRxiv , Wydawca: Cold Spring Harbor Laboratory (CSHL)
    Status:
    Published
    DOI:
    10.1101/2023.03.22.533769 - link to the publication
  1. H4K20me1-mediated epigenetic dysregulation of mTOR/autophagy increases amyloid beta accumulation and cognitive deficits in hyperhomocysteinemic and bleomycin hydrolase-deficient mice
    Authors:
    Łukasz Witucki, Joanna Suszyńska-Zajczyk, Jacek Wróblewski, Hieronim Jakubowski.
    Conference:
    ADPD22_-_LIST_OF_GALLERY_ABSTRACTS_FOR_WEB_January-5th.pdf (tom: AD/PD2022, strony: OO236 / #1479), Wydawca: AD/PD™ 2022, Alzheimer's & Parkinson's Diseases Conference
    Data:
    konferencja March 15-20, 2022
    Status:
    Published
  2. Molecular Bases of Cystathionine β-Synthase Deficiency
    Authors:
    Hieronim Jakubowski
    Conference:
    PROGRAM (tom: 13TH INTERNATIONAL CONFERENCE ONE-CARBON METABOLISM B VITAMINS AND HOMOCYSTEINE, strony: ), Wydawca: Poznań University of Life Sciences, https://www.homocysteine2021.org
    Data:
    konferencja September 12-16, 2021
    Status:
    Published

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