Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Synthesis and biochemical properties of sulfonamide antibiotic derivatives together with analyses of changes in their bioinorganic profiles as a result of complexation with trivalent metal ions (Ru, Rh, Os, Ir)

2019/33/B/ST4/00031

Keywords:

sulfonamide antibiotic derivatives sulfonamide complexes of trivalent metal ions (Ru Rh Os Ir) bioinorganic profiles biological activity cytotoxicity interactions with biomolecules action mechanism

Descriptors:

  • ST4_011:
  • ST4_020:
  • ST4_009:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Makowski 

Number of co-investigators in the project: 15

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 894 200 PLN

Project start date (Y-m-d): 2020-02-05

Project end date (Y-m-d): 2024-02-04

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (31)
  1. Exploring the interactions of biologically active compounds (including drugs) with biomolecules: Utilizing Surface Plasmon Resonance and SwitchSense techniques
    Authors:
    Paulina Nowicka , Sandra Brzeska , Mariusz Makowski
    Academic press:
    Trends in Analytical Chemistry (rok: 2024, tom: 176, strony: 117764), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trac.2024.117764 - link to the publication
  2. t-Butyl 3-azido- and 3-amino-2,3-dideoxy-α- d-arabino-hexopyranosides: a concise protocol of structural and chemical profiles to identify metal ion binding modes
    Authors:
    Aleksandra M. Dąbrowska , Anna Barabaś , Artur Sikorski , Michał Wera , Jakub Brzeski , Marta Domżalska, Agnieszka Chylewska
    Academic press:
    Journal of Coordination Chemistry (rok: 2021, tom: 74, strony: 402-423), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/00958972.2021.1871899 - link to the publication
  3. Application of the SwitchSense Technique for the Study of Small Molecules' (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time
    Authors:
    Sandra Ramotowska, Paulina Spisz, Jakub Brzeski, Aleksandra Ciesielska, Mariusz Makowski
    Academic press:
    The Journal of Physical Chemistry B (rok: 2022, tom: 126, strony: 7238−7251), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.2c03138 - link to the publication
  4. t-Butyl 3-azido- and 3-amino-2,3-dideoxy-α- d-arabino-hexopyranosides: a concise protocol of structural and chemical profiles to identify metal ion binding modes
    Authors:
    Aleksandra M. Dąbrowska , Anna Barabaś , Artur Sikorski , Michał Wera , Jakub Brzeski , Marta Domżalska, Agnieszka Chylewska
    Academic press:
    Journal of Coordination Chemistry (rok: 2021, tom: 74, strony: 402-423), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/00958972.2021.1871899 - link to the publication
  5. On the acid-base properties of pyrazine-2-thiocarboxamide and its complexes with Fe(II), Cu(II), Zn(II) and Ni(II) in polar solvents
    Authors:
    Przemysław Sumczyński, Robert Wieczorek, Mariusz Makowski
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 311, strony: 113349), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.113349 - link to the publication
  6. Sulfonamides differing in the alkylamino substituent length – Synthesis, electrochemical characteristic, acid-base profile and complexation properties
    Authors:
    Aleksandra Ciesielska, Małgorzata Gawrońska, Mariusz Makowski, Sandra Ramotowska
    Academic press:
    Polyhedron (rok: 2022, tom: 221, strony: 115868), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2022.115868 - link to the publication
  7. Application of the SwitchSense Technique for the Study of Small Molecules' (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time
    Authors:
    Sandra Ramotowska, Paulina Spisz, Jakub Brzeski, Aleksandra Ciesielska, Mariusz Makowski
    Academic press:
    The Journal of Physical Chemistry B (rok: 2022, tom: 126, strony: 7238−7251), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.2c03138 - link to the publication
  8. Experimental and theoretical investigation of conformational states and noncovalent interactions in crystalline sulfonamides with a methoxyphenyl moiety
    Authors:
    Mateusz Kowalik, Jakub Brzeski, Małgorzata Gawrońska, Katarzyna Kazimierczuk, Mariusz Makowski
    Academic press:
    CrystEngComm (rok: 2021, tom: 23, strony: 6137–6162), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1ce00869b - link to the publication
  9. A comprehensive approach to the analysis of antibiotic-metal complexes
    Authors:
    Sandra Ramotowska, Małgorzata Wysocka, Jakub Brzeski, Agnieszka Chylewska, Mariusz Makowski
    Academic press:
    Trends in Analytical Chemistry (rok: 2020, tom: 123, strony: 115771), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trac.2019.115771 - link to the publication
  10. Prototropic tautomerism of (E)-N-((4-((2-hydroxy-5-methoxybenzylidene) amino)phenyl)sulfonyl)acetamide and its coordination abilities towards Ru, Rh, and Ir trivalent metal ions
    Authors:
    Aleksandra M. Dąbrowska, Paulina Mech-Warda , Michał Wera , Marta Domżalska , Mariusz Makowski, Agnieszka Chylewska
    Academic press:
    Polyhedron (rok: 2022, tom: 222, strony: 115909), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2022.115909 - link to the publication
  11. Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties
    Authors:
    Paulina Mech-Warda, ArturGiełdoń, Anna Kawiak, Natalia Maciejewska, Mateusz Olszewski, Mariusz Makowski, Agnieszka Chylewska
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 3704), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27123704 - link to the publication
  12. A comprehensive approach to the analysis of antibiotic-metal complexes
    Authors:
    Sandra Ramotowska, Małgorzata Wysocka, Jakub Brzeski, Agnieszka Chylewska, Mariusz Makowski
    Academic press:
    Trends in Analytical Chemistry (rok: 2020, tom: 123, strony: 115771), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trac.2019.115771 - link to the publication
  13. Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties
    Authors:
    Paulina Mech-Warda, ArturGiełdoń, Anna Kawiak, Natalia Maciejewska, Mateusz Olszewski, Mariusz Makowski, Agnieszka Chylewska
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 3704), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27123704 - link to the publication
  14. A comprehensive approach to the analysis of antibiotic-metal complexes
    Authors:
    Sandra Ramotowska, Małgorzata Wysocka, Jakub Brzeski, Agnieszka Chylewska, Mariusz Makowski
    Academic press:
    Trends in Analytical Chemistry (rok: 2020, tom: 123, strony: 115771), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trac.2019.115771 - link to the publication
  15. Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study
    Authors:
    Paulina Spisz, Agnieszka Chylewska , Aleksandra Królicka, Sandra Ramotowska, Aleksandra Dąbrowska, Mariusz Makowski
    Academic press:
    Internationa Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 13482), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222413482 - link to the publication
  16. Experimental and theoretical investigation of conformational states and noncovalent interactions in crystalline sulfonamides with a methoxyphenyl moiety
    Authors:
    Mateusz Kowalik, Jakub Brzeski, Małgorzata Gawrońska, Katarzyna Kazimierczuk, Mariusz Makowski
    Academic press:
    CrystEngComm (rok: 2021, tom: 23, strony: 6137–6162), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1ce00869b - link to the publication
  17. Anticancer Study on IrIII and RhIII Half-Sandwich Complexes with the Bipyridylsulfonamide Ligand
    Authors:
    Mateusz Kowalik, Joanna Masternak, Mateusz Olszewski, Natalia Maciejewska, Katarzyna Kazimierczuk, Jerzy Sitkowski, Aleksandra M. Dąbrowska, Agnieszka Chylewska, Mariusz Makowski
    Academic press:
    Inorganic Chemistry (rok: 2024, tom: 63, strony: 1296−1316), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.3c03801 - link to the publication
  18. Experimental and theoretical investigation of conformational states and noncovalent interactions in crystalline sulfonamides with a methoxyphenyl moiety
    Authors:
    Mateusz Kowalik, Jakub Brzeski, Małgorzata Gawrońska, Katarzyna Kazimierczuk, Mariusz Makowski
    Academic press:
    CrystEngComm (rok: 2021, tom: 23, strony: 6137–6162), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1ce00869b - link to the publication
  19. Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study
    Authors:
    Paulina Spisz, Agnieszka Chylewska , Aleksandra Królicka, Sandra Ramotowska, Aleksandra Dąbrowska, Mariusz Makowski
    Academic press:
    Internationa Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 13482), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222413482 - link to the publication
  20. Theoretical Study on the Alkylamino-Substituted Sulfonamides with Potential Biological Activity
    Authors:
    Jakub Brzeski, Aleksandra Ciesielska, Mariusz Makowski
    Academic press:
    Journal of Physical Chemistry B (rok: 2023, tom: 127, strony: 6620−6627), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.3c01965 - link to the publication
  21. Sulfonamides with hydroxyphenyl moiety: Synthesis, structure, physicochemical properties, and ability to form complexes with Rh(III) ion
    Authors:
    Małgorzata Gawrońska, Mateusz Kowalik, Joanna Duch, Katarzyna Kazimierczuk, Mariusz Makowski
    Academic press:
    Polyhedron (rok: 2022, tom: 221, strony: 115865), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2022.115865 - link to the publication
  22. Sulfonamides differing in the alkylamino substituent length – Synthesis, electrochemical characteristic, acid-base profile and complexation properties
    Authors:
    Aleksandra Ciesielska, Małgorzata Gawrońska, Mariusz Makowski, Sandra Ramotowska
    Academic press:
    Polyhedron (rok: 2022, tom: 221, strony: 115868), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2022.115868 - link to the publication
  23. What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?
    Authors:
    Sandra Ramotowska, Aleksandra Ciesielska, Mariusz Makowski
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 3478), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26113478 - link to the publication
  24. On the acid-base properties of pyrazine-2-thiocarboxamide and its complexes with Fe(II), Cu(II), Zn(II) and Ni(II) in polar solvents
    Authors:
    Przemysław Sumczyński, Robert Wieczorek, Mariusz Makowski
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 311, strony: 113349), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.113349 - link to the publication
  25. What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?
    Authors:
    Sandra Ramotowska, Aleksandra Ciesielska, Mariusz Makowski
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 3478), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26113478 - link to the publication
  26. Prototropic tautomerism of (E)-N-((4-((2-hydroxy-5-methoxybenzylidene) amino)phenyl)sulfonyl)acetamide and its coordination abilities towards Ru, Rh, and Ir trivalent metal ions
    Authors:
    Aleksandra M. Dąbrowska, Paulina Mech-Warda , Michał Wera , Marta Domżalska , Mariusz Makowski, Agnieszka Chylewska
    Academic press:
    Polyhedron (rok: 2022, tom: 222, strony: 115909), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2022.115909 - link to the publication
  27. What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?
    Authors:
    Sandra Ramotowska, Aleksandra Ciesielska, Mariusz Makowski
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 3478), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26113478 - link to the publication
  28. On the acid-base properties of pyrazine-2-thiocarboxamide and its complexes with Fe(II), Cu(II), Zn(II) and Ni(II) in polar solvents
    Authors:
    Przemysław Sumczyński, Robert Wieczorek, Mariusz Makowski
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 311, strony: 113349), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.113349 - link to the publication
  29. Sulfonamides with hydroxyphenyl moiety: Synthesis, structure, physicochemical properties, and ability to form complexes with Rh(III) ion
    Authors:
    Małgorzata Gawrońska, Mateusz Kowalik, Joanna Duch, Katarzyna Kazimierczuk, Mariusz Makowski
    Academic press:
    Polyhedron (rok: 2022, tom: 221, strony: 115865), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2022.115865 - link to the publication
  30. Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study
    Authors:
    Paulina Spisz, Agnieszka Chylewska , Aleksandra Królicka, Sandra Ramotowska, Aleksandra Dąbrowska, Mariusz Makowski
    Academic press:
    Internationa Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 13482), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222413482 - link to the publication
  31. t-Butyl 3-azido- and 3-amino-2,3-dideoxy-α- d-arabino-hexopyranosides: a concise protocol of structural and chemical profiles to identify metal ion binding modes
    Authors:
    Aleksandra M. Dąbrowska , Anna Barabaś , Artur Sikorski , Michał Wera , Jakub Brzeski , Marta Domżalska, Agnieszka Chylewska
    Academic press:
    Journal of Coordination Chemistry (rok: 2021, tom: 74, strony: 402-423), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/00958972.2021.1871899 - link to the publication

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