Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Chemoenzymatic cascades of new Cu and Pd reactions of significant application potential.

2019/33/B/ST4/01118

Keywords:

new reactions palladium CC coupling copper CC coupling chemoenzymatic cascades stereoselective synthesis biocatalysis cancer multidrug resistance..

Descriptors:

  • ST4_014:
  • ST4_008:
  • ST4_017:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Chemii Organicznej Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Józef Ostaszewski 

Number of co-investigators in the project: 5

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 531 200 PLN

Project start date (Y-m-d): 2020-02-20

Project end date (Y-m-d): 2025-02-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (40)
  1. Promiscuous Lipase-Catalyzed Markovnikov Addition ofH-Phosphites to Vinyl Esters for the Synthesis of Cytotoxic α-Acyloxy Phosphonate Derivatives
    Authors:
    P. Kowalczyk, D. Koszelewski, B. Gawdzik, J.Samsonowicz –Górski, K. Kramkowski, A. Wypych, R. Lizut, R. Ostaszewskii
    Academic press:
    Materials (rok: 2022, tom: 15, strony: 175), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma15051975 - link to the publication
  2. The Synthesis and Evaluation of Diethyl Benzylphosphonates as Potential Antimicrobial Agents
    Authors:
    A. Brodzka, P. Kowalczyk, D. Trzepizur, D. Koszelewski, K. Kramkowski, M. Szymczak, A. Wypych, R. Lizut, R. Ostaszewski
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 6865), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27206865 - link to the publication
  3. Evaluation of Antibacterial Activity against Nosocomial Pathogens of an Enzymatically Derived -Aminophosphonates Possessing Coumarin Scaffold
    Authors:
    Paweł Kowalczyk, Dominik Koszelewski, Anna Brodzka, Karol Kramkowski, Ryszard Ostaszewski
    Academic press:
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (rok: 2023, tom: 24, strony: 14886), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms241914886 - link to the publication
  4. Intensification of Double Kinetic Resolution of Chiral Amines and Alcohols via Chemoselective Formation of a Carbonate–Enzyme Intermediate
    Authors:
    J. Samsonowicz –Górski, A. Brodzka, R. Ostaszewski, D. Koszelewski
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 4346), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27144346 - link to the publication
  5. Relationship between Structure and Antibacterial Activity of -Aminophosphonate Derivatives Obtained via Lipase-Catalyzed Kabachnik-Fields Reaction
    Authors:
    D. Koszelewski, P. Kowalczyk, P. Śmigielski, J. Samsonowicz –Górski, K. Kramkowski, A. Wypych, M. Symczak, R. Ostaszewski
    Academic press:
    Materials (rok: 2022, tom: 15, strony: 3846), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma15113846 - link to the publication
  6. Promiscuous Lipase-Catalyzed Knoevenagel–Phospha–Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates
    Authors:
    J. Samsonowicz –Górski, D. Koszelewski, P. Kowalczyk, P. Śmigielski, A. Hrunyk, K. Kramkowski, A. Wypych , M. Szymczak, R. Lizut, R. Ostaszewski
    Academic press:
    Int. J. Mol. Sci. (rok: 2022, tom: 23, strony: 8819), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23158819 - link to the publication
  7. Chemoenzymatic cascade reaction as a sustainable and scalable access to para-quinols
    Authors:
    Jan Samsonowicz-Górski, Anastasiia Hrunyk, Anna Brodzka, Ryszard Ostaszewski, Dominik Koszelewski
    Academic press:
    GREEN CHEMISTRY (rok: 2023, tom: 25, strony: 6306-6314), Wydawca: ROYAL SOC CHEMISTRY
    Status:
    Published
    DOI:
    10.1039/d3gc01638b - link to the publication
  8. The influence of UV light on the course offluorescent enzyme assays
    Authors:
    A. Samborski, P. Jankowski & R. Ostaszewski
    Academic press:
    Preparative Biochemistry & Biotechnology (rok: 2022, tom: 15, strony: 45663), Wydawca: TAYLOR & FRANCIS INC
    Status:
    Published
    DOI:
    10.1080/10826068.2022.2119573 - link to the publication
  9. δ-Lactones—A New Class of Compounds That Are Toxic to E. coli K12, R2-R4 Strains
    Authors:
    P. Kowalczyk,, B. Gawdzik, D. Trzepizur, M. Szymczak, G. Skiba, S. Raj, K. Kramkowski, R. Lizut, R. Ostaszewski
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 2956), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14112956 - link to the publication
  10. Interdisciplinary approach to synthesis, stability and antimicrobial activity of silver nanoparticles
    Authors:
    Dorota Piechota, Patrycja Wardaszka, Wioletta Barańska-Rybak, Maciej Jaśkiewicz, Wojciech Kamysz, Milena Deptuła, Michał Pikuła, Ryszard Ostaszewski
    Academic press:
    POSTEPY DERMATOLOGII I ALERGOLOGII (rok: 2023, tom: 40, strony: 390-397), Wydawca: TERMEDIA PUBLISHING HOUSE LTD
    Status:
    Published
    DOI:
    10.5114/ada.2023.128978 - link to the publication
  11. The Synthesis and Evaluation of Aminocoumarin Peptidomimetics as Cytotoxic Agents on Model Bacterial E. coli Strains
    Authors:
    P. Kowalczyk, M. Wilk, P. Parul, M. Szymczak, D. Koszelewski, K. Kramkowski, S. Raj, G. Skiba, D. Sulejczak, P. Kleczkowska, R. Ostaszewski
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 5725), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14195725 - link to the publication
  12. Promiscuous Lipase-Catalyzed Markovnikov Addition ofH-Phosphites to Vinyl Esters for the Synthesis of Cytotoxic α-Acyloxy Phosphonate Derivatives
    Authors:
    P. Kowalczyk, D. Koszelewski, B. Gawdzik, J.Samsonowicz –Górski, K. Kramkowski, A. Wypych, R. Lizut, R. Ostaszewskii
    Academic press:
    Materials (rok: 2022, tom: 15, strony: 175), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma15051975 - link to the publication
  13. Synthesis and Antimicrobial Activity of the Pathogenic E. coli Strains of p-Quinols: Additive Effects of Copper-Catalyzed Addition of Aryl Boronic Acid to Benzoquinones
    Authors:
    D. Koszelewski, P. Kowalczyk, J. Samsonowicz-Górski, A. Hrunyk, A. Brodzka, J. Łęcka, J. K. Kramkowski, R. Ostaszewski
    Academic press:
    Int. J. Mol. Sci. (rok: 2023, tom: 24, strony: 1623), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24021623 - link to the publication
  14. All That Glitters Is Not Silver—A New Look at Microbiological and Medical Applications of Silver Nanoparticles
    Authors:
    P.Kowalczyk, M. Szymczak, M. Maciejewska, Ł. Laskowski, M. Laskowska, R. Ostaszewski, G. Skiba, I. Franiak-Pietryga
    Academic press:
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (rok: 2021, tom: 22, strony: 854), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/ijms22020854 - link to the publication
  15. Simultaneous Enantiodivergent Synthesis of Diverse Lactones and Lactams via Sequential One-Pot Enzymatic Kinetic Resolution–Ring-Closing Metathesis Reactions
    Authors:
    A. Brodzka, D. Koszelewski, R. Ostaszewski
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 7696), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27227696 - link to the publication
  16. Palladium Catalyzed α,β-Homodiarylation of Vinyl Esters in Aqueous Medium
    Authors:
    D. Trzepizur, A. Brodzka, D. Koszelewski, M. Wilk, R. Ostaszewski
    Academic press:
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (rok: 2021, ), Wydawca: WILEY-V C H VERLAG GMBH
    Status:
    Published
    DOI:
    10.1002/ejoc.202101211 - link to the publication
  17. Selective Esterification of Phosphonic Acids
    Authors:
    D. Trzepizur, A. Brodzka, D. Koszelewski, R. Ostaszewski
    Academic press:
    Molecules (rok: 2021, tom: 25, strony: 5637), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/molecules26185637 - link to the publication
  18. The Synthesis and Evaluation of Amidoximes as Cytotoxic Agents on Model Bacterial E. coli Strains
    Authors:
    J. Samsonowicz Górski, P. Kowalczyk, D. Koszelewski, A. Brodzka, M. Szymczak, K. Kramkowski, R. Ostaszewski
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 7577), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14247577 - link to the publication
  19. Model Studies on the Enzyme-Regulated Stereodivergent Cascade Passerini Reaction
    Authors:
    M Wilk, A Brodzka, D Koszelewski, J Samsonowicz‐Górski, R. Ostaszewski
    Academic press:
    European Journal Of Organic Chemistry (rok: 2021, ), Wydawca: WILEY-V C H VERLAG GMBH
    Status:
    Published
    DOI:
    10.1002/ejoc.202100760 - link to the publication
  20. Pyridine Derivatives—A New Class of Compounds That Are Toxic to E. coli K12, R2–R4 Strains
    Authors:
    D. Koszelewski, R. Ostaszewski, P. Śmigielski, A. Hrunyk, K. Kramkowski, Ł. Laskowski, M. Laskowska, R. Lizut, M. Szymczak, J. Michalski, K. Gawin,P. Kowalczyk
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 5401), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14185401 - link to the publication
  21. The Synthesis and Evaluation of Aminocoumarin Peptidomimetics as Cytotoxic Agents on Model Bacterial E. coli Strains
    Authors:
    P. Kowalczyk, M. Wilk, P. Parul, M. Szymczak, D. Koszelewski, K. Kramkowski, S. Raj, G. Skiba, D. Sulejczak, P. Kleczkowska, R. Ostaszewski
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 5725), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14195725 - link to the publication
  22. The Synthesis and Evaluation of Amidoximes as Cytotoxic Agents on Model Bacterial E. coli Strains
    Authors:
    J. Samsonowicz Górski, P. Kowalczyk, D. Koszelewski, A. Brodzka, M. Szymczak, K. Kramkowski, R. Ostaszewski
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 7577), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14247577 - link to the publication
  23. δ-Lactones—A New Class of Compounds That Are Toxic to E. coli K12, R2-R4 Strains
    Authors:
    P. Kowalczyk,, B. Gawdzik, D. Trzepizur, M. Szymczak, G. Skiba, S. Raj, K. Kramkowski, R. Lizut, R. Ostaszewski
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 2956), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14112956 - link to the publication
  24. Palladium Catalyzed α,β-Homodiarylation of Vinyl Esters in Aqueous Medium
    Authors:
    D. Trzepizur, A. Brodzka, D. Koszelewski, M. Wilk, R. Ostaszewski
    Academic press:
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (rok: 2021, ), Wydawca: WILEY-V C H VERLAG GMBH
    Status:
    Published
    DOI:
    10.1002/ejoc.202101211 - link to the publication
  25. α-Amidoamids as New Replacements of Antibiotics—Research on the Chosen K12, R2–R4 E. coli Strains
    Authors:
    P. Kowalczyk, A. Madej, M. Szymczak, R. Ostaszewski
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 5169), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma13225169 - link to the publication
  26. Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains
    Authors:
    P.Sahrawat , P. Kowalczyk, D. Koszelewski, M. Szymczak, K. Kramkowski, A. Wypych, R. Ostaszewski, D. Koszelewski,
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 3633), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27113633 - link to the publication
  27. 1,2-Diarylethanols - a new class of peptidomimetics that are toxic to E. coli K12, R2-R4 strains
    Authors:
    Kowalczyk P., Trzepizur D., Szymczak M., Skiba G., Kramkowski K., Ostaszewski R.,
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 1025), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14041025 - link to the publication
  28. Enzymatic Synthesis of a Novel Coumarin Aminophosphonates: Antibacterial Effects and Oxidative Stress Modulation on Selected E. coli Strains
    Authors:
    Dominik Koszelewski, Paweł Kowalczyk , Anna Brodzka, Anastasiia Hrunyk, Karol Kramkowski, Ryszard Ostaszewski
    Academic press:
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (rok: 2023, tom: 24, strony: 7609), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  29. Evaluation of gem-diacetates as alternative reagents for enzymatic regio- and stereoselective acylation of alcohols
    Authors:
    D. Koszelewski, A. Brodzka, A. Madej, D. Trzepizur, R. Ostaszewski
    Academic press:
    Journal of Organic Chemisty (rok: 2021, tom: 86, strony: 6331–6342), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.1c00154 - link to the publication
  30. The sustainable copper-catalyzed direct formation of highly functionalized p-quinols in water
    Authors:
    D. Koszelewski, D. Paprocki, A. Brodzka, A. Kęciek, M. Wilk, R. Ostaszewski
    Academic press:
    Sustainable Chemistry and Pharmacy (rok: 2022, tom: 25, strony: 100576), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scp.2021.100576 - link to the publication
  31. Screening for amidoxime reductases in plant roots and Saccharomyces cerevisiae – development of biocatalytic method for chemoselective amidine synthesis
    Authors:
    J. Samsonowicz-Gorski, A. Brodzka, R. Ostaszewski, D. Koszelewski,
    Academic press:
    Bioorganic Chemistry (rok: 2022, tom: 124, strony: 105815), Wydawca: Elsevir
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2022.105815 - link to the publication
  32. The Evaluation of DHPMs as Biotoxic Agents on Pathogen Bacterial Membranes
    Authors:
    B. Gawdzik, P. Kowalczyk, D. Koszelewski, A. Brodzka, J. Masternak, K. Kramkowski, A. Wypych, R. Ostaszewski
    Academic press:
    Membranes (rok: 2022, tom: 12, strony: 238), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/membranes12020238 - link to the publication
  33. Synthesis and Antimicrobial Activity of the Pathogenic E. coli Strains of p-Quinols: Additive Effects of Copper-Catalyzed Addition of Aryl Boronic Acid to Benzoquinones
    Authors:
    D. Koszelewski, P. Kowalczyk, J. Samsonowicz-Górski, A. Hrunyk, A. Brodzka, J. Łęcka, J. K. Kramkowski, R. Ostaszewski
    Academic press:
    Int. J. Mol. Sci. (rok: 2023, tom: 24, strony: 1623), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24021623 - link to the publication
  34. Screening for amidoxime reductases in plant roots and Saccharomyces cerevisiae – development of biocatalytic method for chemoselective amidine synthesis
    Authors:
    J. Samsonowicz-Gorski, A. Brodzka, R. Ostaszewski, D. Koszelewski,
    Academic press:
    Bioorganic Chemistry (rok: 2022, tom: 124, strony: 105815), Wydawca: Elsevir
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2022.105815 - link to the publication
  35. The sustainable copper-catalyzed direct formation of highly functionalized p-quinols in water
    Authors:
    D. Koszelewski, D. Paprocki, A. Brodzka, A. Kęciek, M. Wilk, R. Ostaszewski
    Academic press:
    Sustainable Chemistry and Pharmacy (rok: 2022, tom: 25, strony: 100576), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scp.2021.100576 - link to the publication
  36. The Evaluation of DHPMs as Biotoxic Agents on Pathogen Bacterial Membranes
    Authors:
    B. Gawdzik, P. Kowalczyk, D. Koszelewski, A. Brodzka, J. Masternak, K. Kramkowski, A. Wypych, R. Ostaszewski
    Academic press:
    Membranes (rok: 2022, tom: 12, strony: 238), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/membranes12020238 - link to the publication
  37. Pyridine Derivatives—A New Class of Compounds That Are Toxic to E. coli K12, R2–R4 Strains
    Authors:
    D. Koszelewski, R. Ostaszewski, P. Śmigielski, A. Hrunyk, K. Kramkowski, Ł. Laskowski, M. Laskowska, R. Lizut, M. Szymczak, J. Michalski, K. Gawin,P. Kowalczyk
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 5401), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14185401 - link to the publication
  38. Promiscuous Lipase-Catalyzed Knoevenagel–Phospha–Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates
    Authors:
    J. Samsonowicz –Górski, D. Koszelewski, P. Kowalczyk, P. Śmigielski, A. Hrunyk, K. Kramkowski, A. Wypych , M. Szymczak, R. Lizut, R. Ostaszewski
    Academic press:
    Int. J. Mol. Sci. (rok: 2022, tom: 23, strony: 8819), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23158819 - link to the publication
  39. Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains
    Authors:
    P.Sahrawat , P. Kowalczyk, D. Koszelewski, M. Szymczak, K. Kramkowski, A. Wypych, R. Ostaszewski, D. Koszelewski,
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 3633), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27113633 - link to the publication
  40. 1,2-Diarylethanols - a new class of peptidomimetics that are toxic to E. coli K12, R2-R4 strains
    Authors:
    Kowalczyk P., Trzepizur D., Szymczak M., Skiba G., Kramkowski K., Ostaszewski R.,
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 1025), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ma14041025 - link to the publication

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