The EBI2 receptor/oxysterol signalling in multiple sclerosis pathophysiology, therapy and diagnostics.
2019/33/B/NZ4/03000
Keywords
Descriptors
- NZ4_007: Neurofizjologia
- NZ3_005: Neurobiologia molekularna
- NZ5_003: Patogeneza chorób człowieka
Panel
NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution
Gdański Uniwersytet Medyczny, Wydział Lekarski
Voivodeship: pomorskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
OPUS 17 – announced on 2019-03-15
- Amount awarded
- 1 699 526 PLN
- Project start date
- 2020-12-01
- Project end date
- 2024-11-30
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (6)
-
Systemic inflammation differentially modulates the levels of EBI2 and CH25H/CYP7B1 enzymes in the brain microvascular cells.
- Authors:
- Fionä Caratis, Bartosz Karaszewski, Ilona Klejbor, Tomomi Furihata, Aleksandra Rutkowska
- Academic press:
- bioRxiv (year: 2023, volume: n/a, pages: 16), Publisher: bioRxiv
- Status:
- Published
- DOI:
- 10.1101/2023.04.16.537063 – link to the publication
-
EBI2-oxysterol signalling regulates VE-cadherin expression and multiple sclerosis CD4+ T cell attachment to a human tri-cell spheroid blood-brain barrier model
- Authors:
- Fionä Caratis , Inez Mruk, Klaudia Konieczna-Wolska, Bartłomiej Rojek, Marek Hałas, Paulina Czaplewska, Bartosz Karaszewski, Tomomi Furihata, Aleksandra Rutkowska
- Academic press:
- Brain, Behavior, & Immunity - Health (year: 2025, volume: 47, pages: 101045), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbih.2025.101045 – link to the publication
-
The proton-activated receptor TDAG8 is upregulated in oligodendrocytes during maturation and under acidic conditions
- Authors:
- Mikołaj Opiełka, Fionä Caratis, Martin Hausmann, Maria Velasco-Estevez, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Bartosz Karaszewski, Aleksandra Rutkowska
- Academic press:
- bioRxiv (year: 2023, volume: n/a, pages: 18), Publisher: bioRxiv
- Status:
- Published
- DOI:
- 10.1101/2023.03.02.530787 – link to the publication
-
The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.
- Authors:
- Caratis F, Opiełka M, Hausmann M, Velasco-Estevez M, Rojek B, de Vallière C, Seuwen K, Rogler G, Karaszewski B, Rutkowska A.
- Academic press:
- PLoS One (year: 2024, volume: 19(3), pages: 46041), Publisher: PLOS
- Status:
- Published
- DOI:
- link to the publication
-
The impaired distribution of adenosine deaminase isoenzymes in multiple sclerosis plasma and cerebrospinal fluid.
- Authors:
- Kutryb-Zajac, B., Kawecka, A., Caratis, F., Urbanowicz, K., Braczko, A., Furihata, T., Karaszewski, B., Smolenski, R. T., & Rutkowska, A.
- Academic press:
- Frontiers in Molecular Neuroscience (year: 2022, volume: 15, pages: nie dotyczy), Publisher: Frontiers Media SA
- Status:
- Published
- DOI:
- 10.3389/fnmol.2022.998023 – link to the publication
-
Differential expression and modulation of EBI2 and 7α,25-OHC synthesizing (CH25H, CYP7B1) and degrading (HSD3B7) enzymes in mouse and human brain vascular cells
- Authors:
- Caratis F, Karaszewski B, Klejbor I, Furihata T, Rutkowska A
- Status:
- Accepted for publication