Projects funded by the NCN
The EBI2 receptor/oxysterol signalling in multiple sclerosis pathophysiology, therapy and diagnostics.
2019/33/B/NZ4/03000
Keywords:
EBI2 receptor multiple sclerosis blood-brain barrier lymphocyte migration oxysterols multiple sclerosis diagnostics multiple sclerosis therapy
Descriptors:
- NZ4_007:
- NZ3_005:
- NZ5_003:
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Gdański Uniwersytet Medyczny, Wydział Lekarski
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: OPUS 17 - announced on 2019-03-15
Amount awarded: 1 699 526 PLN
Project start date (Y-m-d): 2020-12-01
Project end date (Y-m-d): 2024-11-30
Project duration:: 48 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- The impaired distribution of adenosine deaminase isoenzymes in multiple sclerosis plasma and cerebrospinal fluid.Authors:Kutryb-Zajac, B., Kawecka, A., Caratis, F., Urbanowicz, K., Braczko, A., Furihata, T., Karaszewski, B., Smolenski, R. T., & Rutkowska, A.Academic press:Frontiers in Molecular Neuroscience (rok: 2022, tom: 15, strony: nie dotyczy), Wydawca: Frontiers Media SAStatus:PublishedDOI:10.3389/fnmol.2022.998023 - link to the publication
- The proton-activated receptor TDAG8 is upregulated in oligodendrocytes during maturation and under acidic conditionsAuthors:Mikołaj Opiełka, Fionä Caratis, Martin Hausmann, Maria Velasco-Estevez, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Bartosz Karaszewski, Aleksandra RutkowskaAcademic press:bioRxiv (rok: 2023, tom: n/a, strony: 18), Wydawca: bioRxivStatus:PublishedDOI:10.1101/2023.03.02.530787 - link to the publication
- Systemic inflammation differentially modulates the levels of EBI2 and CH25H/CYP7B1 enzymes in the brain microvascular cells.Authors:Fionä Caratis, Bartosz Karaszewski, Ilona Klejbor, Tomomi Furihata, Aleksandra RutkowskaAcademic press:bioRxiv (rok: 2023, tom: n/a, strony: 16), Wydawca: bioRxivStatus:PublishedDOI:10.1101/2023.04.16.537063 - link to the publication