Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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A star or a villain: why do pancreatic stellate cells turn "evil" after activation?

2019/33/B/NZ3/02578

Keywords:

calcium signalling pancreas pancreatic stellate cells pancreatic fibrosis alcoholic pancreatitis,

Descriptors:

  • NZ3_002:
  • NZ3_001:
  • NZ5_003:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paweł Eugeniusz Ferdek 

Number of co-investigators in the project: 5

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 954 154 PLN

Project start date (Y-m-d): 2020-07-01

Project end date (Y-m-d): 2026-06-30

Project duration:: 72 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (13)
  1. Activation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites
    Authors:
    Kusiak AA, Jakubowska MA, Stopa KB, Zhang X, Huang W, Gerasimenko JV, Gerasimenko OV, Sutton R, Petersen OH, Ferdek PE
    Academic press:
    Cell Death and Disease (rok: 2022, tom: 13 (8), strony: 744), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41419-022-05186-w - link to the publication
  2. Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research
    Authors:
    Yang X, Yao L, Fu X, Mukherjee R, Xia Q, Jakubowska MA, Ferdek PE, Huang W.
    Academic press:
    Frontiers in Physiology (rok: 2020, tom: 23, strony: 614591), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphys.2020.614591 - link to the publication
  3. Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis via Oxidative Stress and PI3K/Akt Signaling Pathway
    Authors:
    Yang X, Yao L, Yuan M, Zhang X, Jakubowska MA, Ferdek PE, Dai L, Yang J, Jin T, Deng L, Fu X, Du D, Liu T, Criddle DN, Sutton R, Huang W, Xia Q.
    Academic press:
    Frontiers in Pharmacology (rok: 2022, tom: 13, strony: 896523), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2022.896523 - link to the publication
  4. A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis
    Authors:
    Du W, Liu G, Shi N, Tang D, Ferdek PE, Jakubowska MA, Liu S, Zhu X, Zhang J, Yao L, Sang X, Zou S, Liu T, Mukherjee R, Criddle DN, Zheng X, Xia Q, Berggren PO, Huang W, Sutton R, Tian Y, Huang W, Fu X
    Academic press:
    Molecular Therapy (rok: 2022, ), Wydawca: Cell Press
    Status:
    Accepted for publication
    DOI:
    10.1016/j.ymthe.2022.01.033 - link to the publication
  5. Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis via Oxidative Stress and PI3K/Akt Signaling Pathway
    Authors:
    Yang X, Yao L, Yuan M, Zhang X, Jakubowska MA, Ferdek PE, Dai L, Yang J, Jin T, Deng L, Fu X, Du D, Liu T, Criddle DN, Sutton R, Huang W, Xia Q.
    Academic press:
    Frontiers in Pharmacology (rok: 2022, tom: 13, strony: 896523), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2022.896523 - link to the publication
  6. Driver Mutations of Pancreatic Cancer Affect Ca2+ Signaling and ATP Production
    Authors:
    Stopa KB, Łoziński F, Kusiak AA, Litewka J, Krzysztofik D, Mosiołek S, Morys J, Ferdek PE, Jakubowska MA
    Academic press:
    FUNCTION (rok: 2023, tom: 4, strony: zqad035), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/function/zqad035 - link to the publication
  7. A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis
    Authors:
    Du W, Liu G, Shi N, Tang D, Ferdek PE, Jakubowska MA, Liu S, Zhu X, Zhang J, Yao L, Sang X, Zou S, Liu T, Mukherjee R, Criddle DN, Zheng X, Xia Q, Berggren PO, Huang W, Sutton R, Tian Y, Huang W, Fu X
    Academic press:
    Molecular Therapy (rok: 2022, ), Wydawca: Cell Press
    Status:
    Accepted for publication
    DOI:
    10.1016/j.ymthe.2022.01.033 - link to the publication
  8. Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research
    Authors:
    Yang X, Yao L, Fu X, Mukherjee R, Xia Q, Jakubowska MA, Ferdek PE, Huang W.
    Academic press:
    Frontiers in Physiology (rok: 2020, tom: 23, strony: 614591), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphys.2020.614591 - link to the publication
  9. Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research
    Authors:
    Yang X, Yao L, Fu X, Mukherjee R, Xia Q, Jakubowska MA, Ferdek PE, Huang W.
    Academic press:
    Frontiers in Physiology (rok: 2020, tom: 23, strony: 614591), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphys.2020.614591 - link to the publication
  10. A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis
    Authors:
    Du W, Liu G, Shi N, Tang D, Ferdek PE, Jakubowska MA, Liu S, Zhu X, Zhang J, Yao L, Sang X, Zou S, Liu T, Mukherjee R, Criddle DN, Zheng X, Xia Q, Berggren PO, Huang W, Sutton R, Tian Y, Huang W, Fu X
    Academic press:
    Molecular Therapy (rok: 2022, ), Wydawca: Cell Press
    Status:
    Accepted for publication
    DOI:
    10.1016/j.ymthe.2022.01.033 - link to the publication
  11. When healing turns into killing - the pathophysiology of pancreatic and hepatic fibrosis
    Authors:
    Ferdek PE, Krzysztofik D, Stopa KB, Kusiak AA, Paw M, Wnuk D, Jakubowska MA
    Academic press:
    The Journal of Physiology (rok: 2022, tom: 600 (11), strony: 2579-2612), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1113/JP281135 - link to the publication
  12. When healing turns into killing - the pathophysiology of pancreatic and hepatic fibrosis
    Authors:
    Ferdek PE, Krzysztofik D, Stopa KB, Kusiak AA, Paw M, Wnuk D, Jakubowska MA
    Academic press:
    The Journal of Physiology (rok: 2022, tom: 600 (11), strony: 2579-2612), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1113/JP281135 - link to the publication
  13. Activation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites
    Authors:
    Kusiak AA, Jakubowska MA, Stopa KB, Zhang X, Huang W, Gerasimenko JV, Gerasimenko OV, Sutton R, Petersen OH, Ferdek PE
    Academic press:
    Cell Death and Disease (rok: 2022, tom: 13 (8), strony: 744), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41419-022-05186-w - link to the publication

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