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Hemophore-like proteins of anaerobic Bacteroidetes – important virulence factors of key pathogens of human microbiome, related with inflammatory chronic diseases

2019/33/B/NZ6/00292

Keywords:

Porphyromonas gingivalis Bacteroides fragilis Bacteroidetes heme hemophore periodontal diseases inflammatory diseases microbiome

Descriptors:

  • NZ1_002:
  • NZ1_010:
  • NZ6_004:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Teresa Barbara Olczak 

Number of co-investigators in the project: 7

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 398 520 PLN

Project start date (Y-m-d): 2020-02-06

Project end date (Y-m-d): 2024-02-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Porphyromonas gingivalis HmuY and Bacteroides vulgatus Bvu – a novel competitive heme acquisition strategy.
    Authors:
    Siemińska K, Cierpisz P, Śmiga M, Olczak T
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 2237), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22052237 - link to the publication
  2. Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution
    Authors:
    Olczak T, Śmiga M, Antonuk SV. Smalley JW
    Academic press:
    Microbiology and Molecular Biology Reviews (rok: 2024, tom: 45690, strony: e0013123), Wydawca: ASM Journals
    Status:
    Published
    DOI:
    10.1128/mmbr.00131-23 - link to the publication
  3. Comparative analysis of Porphyromonas gingivalis A7436 and ATCC 33277 strains reveals differences in the expression of heme acquisition systems
    Authors:
    Śmiga M, Ślęzak P, Olczak T
    Academic press:
    Microbiology Spectrum (rok: 2024, tom: 45687, strony: e0286523), Wydawca: ASM Journals
    Status:
    Published
    DOI:
    10.1128/spectrum.02865-23 - link to the publication
  4. Interplay between Porphyromonas gingivalis hemophore-like protein HmuY and Kgp/RgpA gingipains plays a superior role in heme supply
    Authors:
    Śmiga M, Ślęzak P, Wagner M, Olczak T
    Academic press:
    Microbiology Spectrum (rok: 2023, tom: 11(2), strony: e0459322), Wydawca: ASM Journals
    Status:
    Published
    DOI:
    10.1128/spectrum.04593-22 - link to the publication
  5. Porphyromonas gingivalis HmuY and Bacteroides vulgatus Bvu – a novel competitive heme acquisition strategy.
    Authors:
    Siemińska K, Cierpisz P, Śmiga M, Olczak T
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 2237), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22052237 - link to the publication
  6. Bacteroides fragilis expresses three proteins similar to Porphyromonas gingivalis HmuY: hemophore-like proteins differentially evolved to participate in heme acquisition in oral and gut microbiomes
    Authors:
    Antonyuk SV, Siemińska K, Śmiga M, Strange RW, Wagner M, Barnett KJ, Olczak T
    Academic press:
    The FASEB Journal (rok: 2023, tom: 37(7), strony: e22981), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202300366R - link to the publication
  7. Porphyromonas gingivalis HmuY and Bacteroides vulgatus Bvu – a novel competitive heme acquisition strategy.
    Authors:
    Siemińska K, Cierpisz P, Śmiga M, Olczak T
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 2237), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22052237 - link to the publication

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