Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Candida spp fungi in aspiration pneumonia - accidental companions or environmental creators for bacterial anaerobial pathogen

2019/33/B/NZ6/02284

Keywords:

Candida spp. biofilm anaerobic bacteria aspiration pneumonia antibiotic therapy

Descriptors:

  • NZ6_007:
  • NZ6_004:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Maria Rąpała-Kozik 

Number of co-investigators in the project: 7

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 147 400 PLN

Project start date (Y-m-d): 2020-02-06

Project end date (Y-m-d): 2023-12-05

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (19)
  • Book publications / chapters in book publications (1)
  1. The efficacy of antimicrobial therapies in the treatment of mixed biofilms formed between Candida albicans and Porphyromonas gingivalis during epithelial cell infection in the aspiration pneumonia model
    Authors:
    Grazyna Bras, Ewelina Wronowska, Miriam Gonzalez-Gonzalez, Magdalena Juszczak, Magdalena Surowiec, Wiktoria Sidlo, Dorota Satala, Kamila Kulig, Justyna Karkowska-Kuleta, Joanna Budziaszek, Joanna Koziel, Maria Rapala-Kozik1*
    Academic press:
    Medical Microbiology and Immunology (rok: 2025, tom: 214, strony: 8), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00430-025-00818-2 - link to the publication
  2. Als3-mediated attachment of enolase on the surface of Candida albicans cells regulates their interactions with host proteins.
    Authors:
    Karkowska-Kuleta, J., Wronowska, E., Satala, D., Zawrotniak, M., Bras, G., Kozik, A., Nobbs, A. H., & Rapala-Kozik, M.
    Academic press:
    Cellular microbiology (rok: 2021, tom: 23(4), strony: e13297), Wydawca: Willey online library
    Status:
    Published
    DOI:
    10.1111/cmi.13297 - link to the publication
  3. Similarities and Differences among Species Closely Related to Candida albicans: C. tropicalis, C. dubliniensis, and C. auris
    Authors:
    Dorota Satala , Magdalena Juszczak , Ewelina Wronowska , Magdalena Surowiec , Kamila Kulig , Andrzej Kozik , Maria Rapala-Kozik , and Justyna Karkowska-Kuleta
    Academic press:
    Cellular Microbiology (rok: 2022, tom: 2022, strony: ID 2599136), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1155/2022/2599136 - link to the publication
  4. Host cell responses to Candida albicans biofilm-derived extracellular vesicles
    Authors:
    Kulig Kamila, Wronowska Ewelina, Juszczak Magdalena, Zawrotniak Marcin, Karkowska-Kuleta Justyna, Rapala-Kozik Maria
    Academic press:
    Frontiers in Cellular and Infection Microbiology (rok: 2025, tom: 14, strony: 1499461), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcimb.2024.1499461 - link to the publication
  5. Proteinous Components of Neutrophil Extracellular Traps Are Arrested by the Cell Wall Proteins of Candida albicans during Fungal Infection, and Can Be Used in the Host Invasion.
    Authors:
    Karkowska-Kuleta, J., Smolarz, M., Seweryn-Ozog, K., Satala, D., Zawrotniak, M., Wronowska, E., Bochenska, O., Kozik, A., Nobbs, A. H., Gogol, M., & Rapala-Kozik, M.
    Academic press:
    Cells (rok: 2021, tom: 10(10), strony: 2736), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10102736 - link to the publication
  6. Extracellular Nucleic Acids Present in the Candida albicans Biofilm Trigger the Release of Neutrophil Extracellular Traps.
    Authors:
    Smolarz, M., Zawrotniak, M., Satala, D., & Rapala-Kozik, M.
    Academic press:
    Frontiers in cellular and infection microbiology (rok: 2021, tom: 11, strony: 681030), Wydawca: FRONTIERS
    Status:
    Published
    DOI:
    10.3389/fcimb.2021.681030 - link to the publication
  7. The role of Candida albicans in the formation of polymicrobial biofilms in the oral cavity.
    Authors:
    Rapala‐Kozik, M., Surowiec, M., Juszczak, M., Wronowska, E., Kulig, K., Bednarek, A., Gonzalez‐Gonzalez, M., Karkowska‐Kuleta, J., Zawrotniak, M., Satała, D., & Kozik, A.
    Academic press:
    Yeast (rok: 2023, tom: 40(8), strony: 303-317), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/yea.3855 - link to the publication
  8. Complexation of fungal Extracellular Nucleic Acids by host LL-37 Peptide Shapes Neutrophil Response to Candida albicans Biofilm
    Authors:
    Magdalena Juszczak, Marcin Zawrotniak, Maria Rapala-Kozik
    Academic press:
    Frontiers in Immunology (rok: 2024, tom: 15, strony: 2024,1295168), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2024.1295168 - link to the publication
  9. The Role of Candida albicans Virulence Factors in the Formation of Multispecies Biofilms With Bacterial Periodontal Pathogens.
    Authors:
    Satala, D., Gonzalez-Gonzalez, M., Smolarz, M., Surowiec, M., Kulig, K., Wronowska, E., Zawrotniak, M., Kozik, A., Rapala-Kozik, M., & Karkowska-Kuleta, J.
    Academic press:
    Frontiers in cellular and infection microbiology (rok: 2022, tom: 11, strony: 765942), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcimb.2021.765942 - link to the publication
  10. Release of neutrophil extracellular traps in response to Candida albicans yeast, as a secondary defense mechanism activated by phagocytosis.
    Authors:
    Zawrotniak, M., Juszczak, M., & Rapała‐Kozik, M.
    Academic press:
    Yeast (rok: 2023, tom: 40(8), strony: 349–359), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/yea.3842 - link to the publication
  11. Cecropin D-derived synthetic peptides in the fight against Candida albicans cell filamentation and biofilm formation.
    Authors:
    Guevara-Lora, I., Bras, G., Juszczak, M., Karkowska-Kuleta, J., Gorecki, A., Manrique-Moreno, M., Dymek, J., Pyza, E., Kozik, A., & Rapala-Kozik, M.
    Academic press:
    Frontiers in Microbiology (rok: 2023, tom: 13, strony: 1045984), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fmicb.2022.1045984 - link to the publication
  12. Insight Into the Properties and Immunoregulatory Effect of Extracellular Vesicles Produced by Candida glabrata, Candida parapsilosis, and Candida tropicalis Biofilms
    Authors:
    Kamila Kulig , Elzbieta Karnas , Olga Woznicka , Patryk Kuleta , Ewa Zuba-Surma , Elzbieta Pyza , Artur Osyczka , Andrzej Kozik , Maria Rapala-Kozik and Justyna Karkowska-Kuleta
    Academic press:
    Front. Cell. Infect. Microbiol. (rok: 2022, tom: 12, strony: 879237), Wydawca: FRONTIERS
    Status:
    Published
    DOI:
    10.3389/fcimb.2022.879237 - link to the publication
  13. The Role of Candida albicans Virulence Factors in the Formation of Multispecies Biofilms With Bacterial Periodontal Pathogens
    Authors:
    Dorota Satala , Miriam Gonzalez-Gonzalez, Magdalena Smolarz, Magdalena Surowiec , Kamila Kulig , Ewelina Wronowska , Marcin Zawrotniak , Andrzej Kozik , Maria Rapala-Kozik and Justyna Karkowska-Kuleta
    Academic press:
    Front. Cell. Infect. Microbiol. (rok: 2022, tom: 11, strony: 765942), Wydawca: FRONTIERS
    Status:
    Published
    DOI:
    10.3389/fcimb.2021.765942 - link to the publication
  14. Insight Into the Properties and Immunoregulatory Effect of Extracellular Vesicles Produced by Candida glabrata, Candida parapsilosis, and Candida tropicalis Biofilms
    Authors:
    Kamila Kulig , Elzbieta Karnas , Olga Woznicka , Patryk Kuleta , Ewa Zuba-Surma , Elzbieta Pyza , Artur Osyczka , Andrzej Kozik , Maria Rapala-Kozik and Justyna Karkowska-Kuleta
    Academic press:
    Front. Cell. Infect. Microbiol. (rok: 2022, tom: 12, strony: 879237), Wydawca: FRONTIERS
    Status:
    Published
    DOI:
    10.3389/fcimb.2022.879237 - link to the publication
  15. Candida parapsilosis cell wall proteins-CPAR2_404800 and CPAR2_404780-Are adhesins that bind to human epithelial and endothelial cells and extracellular matrix proteins
    Authors:
    Satala, D., Karkowska-Kuleta, J., Bras, G., Rapala-Kozik, M., & Kozik, A.
    Academic press:
    Yeast (rok: 2023, tom: 40(8), strony: 377–389), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/yea.3847 - link to the publication
  16. Similarities and Differences among Species Closely Related to Candida albicans: C. tropicalis, C. dubliniensis, and C. auris
    Authors:
    Dorota Satala , Magdalena Juszczak , Ewelina Wronowska , Magdalena Surowiec , Kamila Kulig , Andrzej Kozik , Maria Rapala-Kozik , and Justyna Karkowska-Kuleta
    Academic press:
    Cellular Microbiology (rok: 2022, tom: 2022, strony: ID 2599136), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1155/2022/2599136 - link to the publication
  17. Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi
    Authors:
    Kulig Kamila, Rapala-Kozik, Maria, Karkowska-Kuleta Justyna
    Academic press:
    Current research in microbial sciences (rok: 2024, tom: 7, strony: 100255), Wydawca: : Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.crmicr.2024.100255 - link to the publication
  18. Candida albicans aspartyl protease (Sap6) inhibits neutrophil functon via a Trojan horse" mechanism
    Authors:
    Marcin Zawrotniak, Dorota Satala, Magdalena Juszczak, Grażyna Bras, Maria Rapala-Kozik
    Status:
    Accepted for publication
  19. Synergistic effect of Candida albicans and Porphyromonas gingivalis biofilm on epithelial barier function in a 3D aspration pneumonia model
    Authors:
    Ewelina Wronowska, Ibeth Guevara-Lora, Aleksandra Brankiewicz, Marcin Zawrotniak, Dorota Satała, Justyna Karkowska-Kuleta, Joanna Budziaszek, Joanna Koziel, Maria Rąpała-Kozik
    Status:
    Accepted for publication
  1. Fungi - A Component of the Oral Microbiome Involved in Periodontal Diseases
    Authors:
    Justyna Karkowska-Kuleta, Dorota Satala, Magdalena Smolarz, Marcin Zawrotniak & Maria Rapala-Kozik
    Book:
    Adv Exp Med Biol (rok: 2022, tom: 1373, strony: 113-138), Wydawca: SPRINGER
    Status:
    Published
    DOI:
    10.1007/978-3-030-96881-6_6 - link to the publication

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