Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular basis of hypusination

2019/33/B/NZ1/01839

Keywords:

hypusination eIF5A DHS DOHH structural biology

Descriptors:

  • NZ1_004:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Przemysław Marek Grudnik 

Number of co-investigators in the project: 5

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 486 200 PLN

Project start date (Y-m-d): 2020-02-24

Project end date (Y-m-d): 2024-05-23

Project duration:: 51 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Half Way to Hypusine—Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase
    Authors:
    Wator E., WIlk P., Grudnik P.
    Academic press:
    Biomolecules (rok: 2020, tom: 10(4), strony: 522), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10040522 - link to the publication
  2. Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase.
    Authors:
    Wątor E, Wilk P, Kochanowski P, Grudnik P.
    Academic press:
    FEBS Journal (rok: 2024, tom: 10.1111/febs.17207, strony: 0), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/febs.17207 - link to the publication
  3. Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase.
    Authors:
    Wątor E, Wilk P, Kochanowski P, Grudnik P.
    Academic press:
    FEBS Journal (rok: 2024, tom: 10.1111/febs.17207, strony: 0), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/febs.17207 - link to the publication
  4. Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders
    Authors:
    Wątor, E., Wilk, P., Biela, A., Rawski, M., Zak, K. M., Steinchen, W., Bange, G., Glatt, S., & Grudnik, P.
    Academic press:
    Nature Communications (rok: 2023, tom: 14, strony: 1698), Wydawca: Springer-Nature
    Status:
    Published
    DOI:
    10.1038/s41467-023-37305-2 - link to the publication

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