The effect of cytosolic adaptive responses associated with long-term mitochondrial stress on the Tau protein aggregation.
2019/33/B/NZ3/00533
Keywords
Descriptors
- NZ3_001: Biologia komórki
- NZ1_002: Biochemia
- NZ3_005: Neurobiologia molekularna
Panel
NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution
Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
OPUS 17 – announced on 2019-03-15
- Amount awarded
- 1 491 100 PLN
- Project start date
- 2020-04-23
- Project end date
- 2023-10-22
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (2)
-
Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction.
- Authors:
- Minji Kim, Remigiusz A. Serwa, Lukasz Samluk, Ida Suppanz, Agata Kodroń, Tomasz M. Stępkowski, Praveenraj Elancheliyan, Biniyam Tsegaye, SilkeOeljeklaus, Michal Wasilewski, Bettina Warscheid, and Agnieszka Chacinska
- Academic press:
- Nature communications (year: 2023, volume: 14, pages: Article number: 4092), Publisher: Nature Portfolio
- Status:
- Published
- DOI:
- 10.1038/s41467-023-39642-8 – link to the publication
-
Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis.
- Authors:
- Lukasz Samluk*, Piotr Ostapczuk, and Magdalena Dziembowska
- Academic press:
- Molecular Biology of the Cell (MBoC) (year: 2022, volume: 33, pages: ar67), Publisher: American Society of Cell Biology
- Status:
- Published
- DOI:
- 10.1091/mbc.E21-11-0553 – link to the publication