Linking abnormal Ca2+ signaling and the unfolded protein response with Huntington's disease pathology in both YAC128 mouse model and iPSC-derived neurons from HD patients
2019/33/B/NZ3/02889
Keywords
Descriptors
- NZ3_005: Neurobiologia molekularna
- NZ3_006: Neurobiologia komórkowa
- NZ3_007: Przekaźnictwo sygnału
Panel
NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution
Międzynarodowy Instytut Biologii Molekularnej i Komórkowej
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
OPUS 17 – announced on 2019-03-15
- Amount awarded
- 1 857 550 PLN
- Project start date
- 2020-04-01
- Project end date
- 2024-09-30
- Project duration
- 54 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (5)
-
Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington's Disease
- Authors:
- Ewelina Latoszek, Magdalena Czeredys
- Academic press:
- Front. Cell Dev. Biol. (year: 2021, volume: 9:657337), Publisher: Frontiers Media S.A.
- Status:
- Published
- DOI:
- 10.3389/fcell.2021.657337 – link to the publication
-
Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease
- Authors:
- Magdalena Czeredys
- Academic press:
- Front. Cell Dev. Biol. (year: 2020, volume: 8:611735), Publisher: Frontiers Media S.A.
- Status:
- Published
- DOI:
- 10.3389/fcell.2020.611735 – link to the publication
-
Generation of three human iPSC lines from patients with Huntington's disease with different CAG lengths and human control iPSC line from a healthy donor
- Authors:
- Latoszek E, Piechota M, Liszewska E, Hansíková H, Klempíř J, Mühlbäck A, Landwehrmeyer GB, Kuznicki J, Czeredys M.
- Academic press:
- Stem Cell Research (year: 2022, volume: 64, pages: 46027), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.scr.2022.102931 – link to the publication
-
Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington's disease models
- Authors:
- Latoszek E, Wiweger M, Ludwiczak J, Dunin-Horkawicz S, Kuznicki J, Czeredys M.
- Academic press:
- Cell & Bioscience (year: 2022, volume: 0,523611111111111, pages: 46043), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1186/s13578-022-00755-0 – link to the publication
-
Generation of two human iPSC lines from dermal fibroblasts of adult- and juvenile-onset Huntington's disease patients and two healthy donors.
- Authors:
- Piechota M, Latoszek E, Liszewska E, Hansíková H, Klempíř J, Mühlbäck A, Landwehrmeyer GB, Kuźnicki J, Czeredys M.
- Academic press:
- Stem Cell Research (year: 2023, volume: 71, pages: 46027), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.scr.2023.103194 – link to the publication