Projects funded by the NCN
Analysis of the role of cytoplasmic polyadenylation in the regulation of the innate immune response
2019/33/B/NZ2/01773
Keywords:
TENT5A TENT5C PQN-44 cytoplasmic polyadenylation innate immune response Caenorhabdidtis elegans Mus musculus
Descriptors:
- NZ2_001:
- NZ2_002:
- NZ6_001:
Panel:
NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology
Host institution :
Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie
woj. mazowieckie
Principal investigator (from the host institution):
prof. Andrzej Stanisław Dziembowski
Number of co-investigators in the project: 6
Call: OPUS 17 - announced on 2019-03-15
Amount awarded: 2 324 800 PLN
Project start date (Y-m-d): 2020-03-02
Project end date (Y-m-d): 2024-03-01
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (5)
- A long noncoding RNA promotes parasite differentiation in African trypanosomesAuthors:Fabien Guegan 1, K Shanmugha Rajan 2, Fábio Bento 1, Daniel Pinto-Neves 1, Mariana Sequeira 1, Natalia Gumińska 3, Seweryn Mroczek 3 4, Andrzej Dziembowski 3, Smadar Cohen-Chalamish 2, Tirza Doniger 2, Beathrice Galili 2, Antonio M Estévez 5, Cedric Notredame 6 7, Shulamit Michaeli 2, Luisa M Figueiredo 1Academic press:Science Advances (rok: 2022, tom: 8, strony: 45677), Wydawca: American Association for the Advancement of ScienceStatus:PublishedDOI:10.1126/sciadv.abn2706 - link to the publication
- Cytoplasmic polyadenylation by TENT5A is required for proper bone formationAuthors:Olga Gewartowska, Goretti Aranaz Novaliches, Paweł S. Krawczyk, Seweryn Mroczek, Monika Kusio-Kobiałka, Bartosz Tarkowski, Frantisek Spoutil, Oldrich Benada, Olga Kofroňová, Piotr Szwedziak, Dominik Cysewski, Jakub Gruchota, Marcin Szpila, Aleksander Chlebowski, Radislav Sedlacek, Jan Prochazka, Andrzej DziembowskiAcademic press:Cell Reports (rok: 2021, tom: 35(3):109015, strony: 45672), Wydawca: Cell PressStatus:PublishedDOI:10.1016/j.celrep.2021.109015 - link to the publication
- TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animalsAuthors:Vladyslava Liudkovska, Paweł S Krawczyk, Aleksandra Brouze, Natalia Gumińska, Tomasz Wegierski, Dominik Cysewski, Zuzanna Mackiewicz,c Jonathan J Ewbank , Krzysztof Drabikowski, Seweryn Mroczek, Andrzej Dziembowski,Academic press:Science Advances (rok: 2022, tom: 8, strony: 45678), Wydawca: American Association for the Advancement of ScienceStatus:PublishedDOI:10.1126/sciadv.add9468 - link to the publication
- Functions and mechanisms of RNA tailing by metazoan terminal nucleotidyltransferasesAuthors:Liudkovska V, Dziembowski A.Academic press:Wiley Interdiscip Rev RNA (rok: 2020, tom: 12(2):e1622, strony: 12785), Wydawca: Wiley Periodicals LLCStatus:PublishedDOI:10.1002/wrna.1622 - link to the publication
- SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune responseAuthors:Pawel Krawczyk, Seweryn Mroczek, Michał Mazur, Olga Gewartowska, Wiktoria Orzeł, Sebastian Jeleń, Wiktor Antczak, Aleksandra Brouze, Katarzyna Matylla-Kulińska, Bartosz Tarkowski, Ewelina Owczarek, Karolina Kasztelan, Kamila Affek, Paweł Turowski, Aleksandra Wesołowska, Tomasz Śpiewla, Monika Kusio-Kobiałka, Dominika Nowis, Jakub Gołąb, Joanna Kowalska, Jacek Jemielity, Andrzej Dziembowski.Status:Accepted for publication