Analysis of the role of cytoplasmic polyadenylation in the regulation of the innate immune response
2019/33/B/NZ2/01773
Keywords
Descriptors
- NZ2_001: Genetyka molekularna
- NZ2_002: Genomika, transkryptomika i epigenomika
- NZ6_001: Odporność swoista i nieswoista
Panel
NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology
Host institution
Międzynarodowy Instytut Biologii Molekularnej i Komórkowej
Voivodeship: mazowieckie
Principal investigator (from the host institution)
prof. Andrzej Stanisław Dziembowski
Number of co-investigators in the project: 6
Call
OPUS 17 – announced on 2019-03-15
- Amount awarded
- 2 324 800 PLN
- Project start date
- 2020-03-02
- Project end date
- 2024-03-01
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (5)
-
TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animals
- Authors:
- Vladyslava Liudkovska, Paweł S Krawczyk, Aleksandra Brouze, Natalia Gumińska, Tomasz Wegierski, Dominik Cysewski, Zuzanna Mackiewicz,c Jonathan J Ewbank , Krzysztof Drabikowski, Seweryn Mroczek, Andrzej Dziembowski,
- Academic press:
- Science Advances (year: 2022, volume: 8, pages: 46043), Publisher: American Association for the Advancement of Science
- Status:
- Published
- DOI:
- 10.1126/sciadv.add9468 – link to the publication
-
A long noncoding RNA promotes parasite differentiation in African trypanosomes
- Authors:
- Fabien Guegan 1, K Shanmugha Rajan 2, Fábio Bento 1, Daniel Pinto-Neves 1, Mariana Sequeira 1, Natalia Gumińska 3, Seweryn Mroczek 3 4, Andrzej Dziembowski 3, Smadar Cohen-Chalamish 2, Tirza Doniger 2, Beathrice Galili 2, Antonio M Estévez 5, Cedric Notredame 6 7, Shulamit Michaeli 2, Luisa M Figueiredo 1
- Academic press:
- Science Advances (year: 2022, volume: 8, pages: 46042), Publisher: American Association for the Advancement of Science
- Status:
- Published
- DOI:
- 10.1126/sciadv.abn2706 – link to the publication
-
Functions and mechanisms of RNA tailing by metazoan terminal nucleotidyltransferases
- Authors:
- Liudkovska V, Dziembowski A.
- Academic press:
- Wiley Interdiscip Rev RNA (year: 2020, volume: 12(2):e1622, pages: 12785), Publisher: Wiley Periodicals LLC
- Status:
- Published
- DOI:
- 10.1002/wrna.1622 – link to the publication
-
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
- Authors:
- Olga Gewartowska, Goretti Aranaz Novaliches, Paweł S. Krawczyk, Seweryn Mroczek, Monika Kusio-Kobiałka, Bartosz Tarkowski, Frantisek Spoutil, Oldrich Benada, Olga Kofroňová, Piotr Szwedziak, Dominik Cysewski, Jakub Gruchota, Marcin Szpila, Aleksander Chlebowski, Radislav Sedlacek, Jan Prochazka, Andrzej Dziembowski
- Academic press:
- Cell Reports (year: 2021, volume: 35(3):109015, pages: 46037), Publisher: Cell Press
- Status:
- Published
- DOI:
- 10.1016/j.celrep.2021.109015 – link to the publication
-
SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response
- Authors:
- Pawel Krawczyk, Seweryn Mroczek, Michał Mazur, Olga Gewartowska, Wiktoria Orzeł, Sebastian Jeleń, Wiktor Antczak, Aleksandra Brouze, Katarzyna Matylla-Kulińska, Bartosz Tarkowski, Ewelina Owczarek, Karolina Kasztelan, Kamila Affek, Paweł Turowski, Aleksandra Wesołowska, Tomasz Śpiewla, Monika Kusio-Kobiałka, Dominika Nowis, Jakub Gołąb, Joanna Kowalska, Jacek Jemielity, Andrzej Dziembowski.
- Status:
- Accepted for publication