Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The importance of the crosstalk between alpha-synuclein and sphingosine-1-phosphate-dependent signalling in experimental models of Parkinson's disease. Searching for novel therapeutic targets in synucleinopathies

2019/32/C/NZ4/00455

Keywords:

sphingosine-1-phosphate alpha-synuclein Parkinson's disease

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ3_5: Molecular neurobiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Motyl 

Number of co-investigators in the project: 2

Call: SONATINA 3 - announced on 2018-12-14

Amount awarded: 1 055 737 PLN

Project start date (Y-m-d): 2019-11-29

Project end date (Y-m-d): 2026-05-28

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (3)
  1. Recent Insights into the Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson's Disease
    Authors:
    Joanna A Motyl, Joanna B Strosznajder, Agnieszka Wencel, Robert P Strosznajder
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6277), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126277. - link to the publication
  1. Ceramide-mediated insult is potentiated by sphingosine kinase 1 inhibition and mitigated by sphingosine-1-phosphate receptors activation in alpha-synuclein transduced cells
    Authors:
    Joanna A. Motyl, Agnieszka Wencel, Robert P. Strosznajder
    Conference:
    Neuropatologia Neuroscience (rok: 2021, ), Wydawca: Termedia Publishing House
    Data:
    konferencja 45615
    Status:
    Published
  2. The role of ceramide/sphingosine kinase 1 and sphingosine-1-phosphate receptors signalling in α-synuclein transduced cells
    Authors:
    Joanna A. Motyl, Agnieszka Wencel, Kinga Czubowicz, Robert P. Strosznajder
    Conference:
    Neuropatologia 2023 (rok: 2023, ), Wydawca: Termedia Publishing House
    Data:
    konferencja 17-18 November
    Status:
    Published
  3. The role of sphingosine kinase 1/sphingosine-1-phosphate receptors signalling under ceramide toxicity in alpha-synuclein transduced cells
    Authors:
    Joanna A. Motyl, Agnieszka Wencel , Iga Wieczorek , Kinga Czubowicz , Robert P. Strosznajder
    Conference:
    The XVth International Symposium Molecular Basis of Pathology and Therapy in Neurological Disorders (rok: 2022, ), Wydawca: Termedia Publishing House
    Data:
    konferencja 20-22 October
    Status:
    Published

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