Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of autophagy in the regulation of secretion of extracellular vesicles and proteins at different stages of vascular smooth muscle cells senescence.

2018/31/B/NZ3/02931

Keywords:

cellular senescence autophagy secretion extracellular vesicles

Descriptors:

  • NZ3_4: Ageing
  • NZ3_1: Cell biology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grażyna Mosieniak 

Number of co-investigators in the project: 8

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 545 300 PLN

Project start date (Y-m-d): 2019-07-24

Project end date (Y-m-d): 2024-07-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Fiji-Based Tool for Rapid and Unbiased Analysis of SA-β-Gal Activity in Cultured Cells
    Authors:
    Krzystyniak A, Gluchowska A, Mosieniak G, Sikora E.
    Academic press:
    Biomolecules (rok: 2023, tom: 13(2), strony: 362), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom13020362 - link to the publication
  2. Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions
    Authors:
    Agata Głuchowska, Dominik Cysewski, Monika Baj-Krzyworzeka, Rafał Szatanek, Kazimierz Węglarczyk, Paulina Podszywałow-Bartnicka, Piotr Sunderland, Ewa Kozłowska, Małgorzata A Śliwińska, Michał Dąbrowski, Ewa Sikora, Grażyna Mosieniak
    Academic press:
    Geroscience (rok: 2022, tom: 44, strony: 2863-28884), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-022-00625-0. - link to the publication
  3. Lack of activity of the mitochondrial large-conductance calcium- regulated potassium channels in senescent vascular smooth muscle cells.
    Authors:
    Głuchowska A, Kalenik B, Kulawiak B, Wrzosek A, Szewczyk A, Bednarczyk P, Mosieniak G.
    Academic press:
    Mechanisms of Ageing and Development (rok: 2023, tom: 215, strony: 111871), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mad.2023.111871 - link to the publication
  4. A common signature of cellular senescence; does it exist?
    Authors:
    Sikora E, Bielak-Zmijewska A, Mosieniak G.
    Academic press:
    Aging Research Review (rok: 2021, tom: 71, strony: 101458), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2021.101458 - link to the publication

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