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Identification and characterization of a new potential heme-binding site in the mitochondrial large-conductance calcium activated potassium channel

2018/31/N/NZ1/00928

Keywords

Descriptors

  • NZ1_3: Biofizyka
  • NZ1_2: Biochemia
  • NZ1_1: Biologia molekularna

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Agnieszka Walewska

Number of co-investigators in the project: 2

Call

PRELUDIUM 16 – announced on 2018-09-14

Amount awarded
70 000 PLN
Project start date
2019-07-09
Project end date
2021-07-08
Project duration
24 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System perfuzji pipety. Cost: 20 300 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Targeting Mitochondrial Large-Conductance Calcium-Activated Potassium Channel by Hydrogen Sulfide via Heme-Binding Site

    Authors:
    Agnieszka Walewska, Adam Szewczyk, Milena Krajewska, and Piotr Koprowski
    Academic press:
    THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (year: 2022, volume: 381, pages: 137-150), Publisher: The American Society for Pharmacology and Experimental Therapeutics
    Status:
    Published
    DOI:
    10.1124/jpet.121.001017 – link to the publication

  2. External Hemin as an Inhibitor of Mitochondrial Large-Conductance Calcium-Activated Potassium Channel Activity

    Authors:
    Agnieszka Walewska, Adam Szewczyk, Piotr Koprowski
    Academic press:
    International Journal o f Molecular Sciences (year: 2022, volume: 23, pages: 13391 (1-16)), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232113391 – link to the publication

  3. Methods of Measuring Mitochondrial Potassium Channels: A Critical Assessment

    Authors:
    Agnieszka Walewska, Milena Krajewska, Aleksandra Stefanowska, Aleksandra Buta, Renata Bilewicz, Paweł Krysiński , Piotr Bednarczyk, Piotr Koprowski,Adam Szewczyk
    Academic press:
    International Journal o f Molecular Sciences (year: 2022, volume: 23(3), pages: 1210-1232), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031210 – link to the publication

Articles in post-conference publications (5)

  1. REGULATION OF THE ACTIVITY OF LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL FROM THE INNER MITOCHONDRIAL MEMBRANE BY EXTERNAL HEME

    Authors:
    A. Walewska, P. Koprowski, A. Szewczyk
    Conference:
    I Wirtualna Konferencja Naukowa Kampusu Ochota (year: 2020, pages: 158), Publisher: Uniwersytet Warszawski
    Date:
    conference 30.06-01.07.2020
    Status:
    Published

  2. Regulation of the Activity of Mitochondrial Large-Conductance Calcium- Activated Potassium Channel Through a New External Heme-Binding Site

    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam M. Szewczyk.
    Conference:
    65th Biophysical Society Virtual Annual Meeting (year: 2021, pages: 155a), Publisher: Biophysical Journal
    Date:
    conference 22-26.02.2021
    Status:
    Published

  3. Regulation of the activity of mitoBKCa channel by hemin and H2S via heme-binding sites

    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    9th Mitochondrion On-line (year: 2021, pages: 24), Publisher: Instytut Biologii Doświadczalnej im. M. Nenckiego, PAN; Polskie Towarzystwo Biochemiczne; PTBF
    Date:
    conference 27.01.2021
    Status:
    Published

  4. Regulation of the activity of mitoBK channel by hemin and hydrogen sulfide via new external heme-binding site

    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    The 45th FEBS Virtual Congress (year: 2021, pages: 229), Publisher: FEBS PRESS
    Date:
    conference 03-08.07.2021
    Status:
    Published

  5. Identification of a new hypothetical external heme-binding site in mitochondrial large-conductance calcium-activated potassium channel

    Authors:
    Agnieszka Walewska, Piotr Koprowski
    Conference:
    8th Mitochondrion in memory of Professor Lech Wojtczak (year: 2020, pages: 22), Publisher: Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Polskie Towarzystwo Biochemiczne, Fundacja M. Nencki
    Date:
    conference 05.02.2020
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Patch-Clamp Recording of the Activity of Ion Channels in the Inner Mitochondrial Membrane

    Authors:
    Piotr Bednarczyk, Rafał Kampa, Shur Gałecka, Aleksandra Sęk, Agnieszka Walewska, Piotr Koprowski
    Book:
    Mitochondrial Medicine: Volume 2: Assessing Mitochondria, Methods in Molecular Biology, vol. 2276 (year: 2021, volume: 2, pages: 235-248), Publisher: Springer New York Heidelberg Dordrecht London
    Status:
    Published

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