Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Identification and characterization of a new potential heme-binding site in the mitochondrial large-conductance calcium activated potassium channel

2018/31/N/NZ1/00928

Keywords:

mitochondrial potassium channels heme hemin gasotransmitters heme binding site

Descriptors:

  • NZ1_3: Biophysics
  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Agnieszka Walewska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 16 - announced on 2018-09-14

Amount awarded: 70 000 PLN

Project start date (Y-m-d): 2019-07-09

Project end date (Y-m-d): 2021-07-08

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System perfuzji pipety (20 300 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (5)
  • Book publications / chapters in book publications (1)
  1. Targeting Mitochondrial Large-Conductance Calcium-Activated Potassium Channel by Hydrogen Sulfide via Heme-Binding Site
    Authors:
    Agnieszka Walewska, Adam Szewczyk, Milena Krajewska, and Piotr Koprowski
    Academic press:
    THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (rok: 2022, tom: 381, strony: 137-150), Wydawca: The American Society for Pharmacology and Experimental Therapeutics
    Status:
    Published
    DOI:
    10.1124/jpet.121.001017 - link to the publication
  2. External Hemin as an Inhibitor of Mitochondrial Large-Conductance Calcium-Activated Potassium Channel Activity
    Authors:
    Agnieszka Walewska, Adam Szewczyk, Piotr Koprowski
    Academic press:
    International Journal o f Molecular Sciences (rok: 2022, tom: 23, strony: 13391 (1-16)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232113391 - link to the publication
  3. Methods of Measuring Mitochondrial Potassium Channels: A Critical Assessment
    Authors:
    Agnieszka Walewska, Milena Krajewska, Aleksandra Stefanowska, Aleksandra Buta, Renata Bilewicz, Paweł Krysiński , Piotr Bednarczyk, Piotr Koprowski,Adam Szewczyk
    Academic press:
    International Journal o f Molecular Sciences (rok: 2022, tom: 23(3), strony: 1210-1232), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031210 - link to the publication
  1. Regulation of the activity of mitoBK channel by hemin and hydrogen sulfide via new external heme-binding site
    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    The 45th FEBS Virtual Congress (rok: 2021, ), Wydawca: FEBS PRESS
    Data:
    konferencja 03-08.07.2021
    Status:
    Published
  2. Identification of a new hypothetical external heme-binding site in mitochondrial large-conductance calcium-activated potassium channel
    Authors:
    Agnieszka Walewska, Piotr Koprowski
    Conference:
    8th Mitochondrion in memory of Professor Lech Wojtczak (rok: 2020, ), Wydawca: Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Polskie Towarzystwo Biochemiczne, Fundacja M. Nencki
    Data:
    konferencja 05.02.2020
    Status:
    Published
  3. REGULATION OF THE ACTIVITY OF LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL FROM THE INNER MITOCHONDRIAL MEMBRANE BY EXTERNAL HEME
    Authors:
    A. Walewska, P. Koprowski, A. Szewczyk
    Conference:
    I Wirtualna Konferencja Naukowa Kampusu Ochota (rok: 2020, ), Wydawca: Uniwersytet Warszawski
    Data:
    konferencja 30.06-01.07.2020
    Status:
    Published
  4. Regulation of the Activity of Mitochondrial Large-Conductance Calcium- Activated Potassium Channel Through a New External Heme-Binding Site
    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam M. Szewczyk.
    Conference:
    65th Biophysical Society Virtual Annual Meeting (rok: 2021, ), Wydawca: Biophysical Journal
    Data:
    konferencja 22-26.02.2021
    Status:
    Published
  5. Regulation of the activity of mitoBKCa channel by hemin and H2S via heme-binding sites
    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    9th Mitochondrion On-line (rok: 2021, ), Wydawca: Instytut Biologii Doświadczalnej im. M. Nenckiego, PAN; Polskie Towarzystwo Biochemiczne; PTBF
    Data:
    konferencja 27.01.2021
    Status:
    Published
  1. Patch-Clamp Recording of the Activity of Ion Channels in the Inner Mitochondrial Membrane
    Authors:
    Piotr Bednarczyk, Rafał Kampa, Shur Gałecka, Aleksandra Sęk, Agnieszka Walewska, Piotr Koprowski
    Book:
    Mitochondrial Medicine: Volume 2: Assessing Mitochondria, Methods in Molecular Biology, vol. 2276 (rok: 2021, tom: 2, strony: 235-248), Wydawca: Springer New York Heidelberg Dordrecht London
    Status:
    Published

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