Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of metallothionein zinc-load states in regulation of p53 tumor supressor activity

2018/31/N/ST4/01909

Keywords:

metallothionein zinc p53,

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_6: Instrumental methods in chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Manuel Peris Diaz 

Number of co-investigators in the project: 2

Call: PRELUDIUM 16 - announced on 2018-09-14

Amount awarded: 172 200 PLN

Project start date (Y-m-d): 2019-08-07

Project end date (Y-m-d): 2023-02-06

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wirówka, z chłodzeniem (35 000 PLN)
  2. Laptop (3 500 PLN)
  3. Oprogramowanie.

Information in the final report

  • Publication in academic press/journals (5)
  1. A guide to good practice in chemometric methods for vibrational spectroscopy, electrochemistry, and hyphenated mass spectrometry
    Authors:
    Manuel David Peris-Diaz, Artur Krężel
    Academic press:
    TrAC Trends in Analytical Chemistry (rok: 2021, tom: 135, strony: 116157), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trac.2020.116157 - link to the publication
  2. An Integrated Mass Spectrometry and Molecular Dynamics Simulations Approach Reveals the Spatial Organization Impact of Metal-Binding Sites on the Stability of Metal-Depleted Metallothionein-2 Species
    Authors:
    Manuel David Peris-Díaz, Roman Guran, Carmen Domene, Vivian de los Rios, Ondrej Zitka, Vojtech Adam and Artur Krężel
    Academic press:
    Journal of the American Chemical Society (rok: 2021, tom: 143, 40, strony: 16486–16501), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jacs.1c05495 - link to the publication
  3. Ion mobility mass spectrometry and molecular dynamics simulations unravel the conformational stability and coordination dynamics of human metallothionein-2 species.
    Authors:
    Manuel David Peris-Díaz, Alexey Barkhanskiy, Ellen Liggett, Perdita Barran, Artur Krężel
    Academic press:
    Chemical Communications (rok: 2023, ), Wydawca: Royal Society Chemistry
    Status:
    Accepted for publication
    DOI:
    10.1039/d2cc06559b - link to the publication
  4. R-MetaboList 2: A Flexible Tool for Metabolite Annotation from High-Resolution Data-Independent Acquisition Mass Spectrometry Analysis
    Authors:
    Manuel D. Peris-Díaz, Shannon R. Sweeney, Olga Rodak, Enrique Sentandreu and Stefano Tiziani
    Academic press:
    Metabolites (rok: 2019, tom: 17, strony: 187), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/metabo9090187 - link to the publication
  5. Structural Characterization of Cu(I)/Zn(II)-metallothionein-3 by Ion Mobility Mass Spectrometry and Top-Down Mass Spectrometry
    Authors:
    Manuel David Peris-Diaz, Sylwia Wu, Karolina Mosna, Ellen Liggett, Alexey Barkhanskiy, Alicja Orzeł, Perdita Barran, and Artur Krężel
    Academic press:
    Analytical Chemistry (rok: 2023, tom: 95, strony: 10966-10974), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.analchem.3c00989 - link to the publication

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