Searching for effective strategies to protect neuronal cells against hypoxia and

Searching for effective strategies to protect neuronal cells against hypoxia and ischemia: Identification of neuroprotective mechanisms of the new ligands of AhR and PPARg in experimental models of stroke.

2018/31/B/NZ7/01815

Keywords

Descriptors

NZ7_14: Farmacja, farmakoterapia, farmakologia
NZ3_5: Neurobiologia molekularna
NZ3_3: Apoptoza

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Małgorzata Kajta

Number of co-investigators in the project: 5

Call

OPUS 16 – announced on 2018-09-14

Amount awarded: 1 362 200 PLN
Project start date: 2019-06-28
Project end date: 2023-06-27
Project duration: 48 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (3)

Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes

Authors:
Rzemieniec J, Bratek E, Wnuk A, Przepiórska K, Salińska E, Kajta M

Academic press:
Apoptosis (year: 2020, volume: 25 (9-10), pages: 747-762), Publisher: Springer

Status:
Published

DOI:
10.1007/s10495-020-01631-3 – link to the publication
Post-Treatment with Amorfrutin B Evokes PPARγ-Mediated Neuroprotection against Hypoxia and Ischemia

Authors:
Wnuk A, Przepiórska K, Pietrzak BA, Kajta M.

Academic press:
Biomedicines (year: 2021, volume: 9, 854, pages: 46047), Publisher: MDPI Academic Open Access Publishing

Status:
Published

DOI:
10.3390/biomedicines9080854 – link to the publication
Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation

Authors:
Przepiórska K, Wnuk A, Beyer C, Kajta M.

Academic press:
Molecular Neurobiology (year: 2023, volume: 60, pages: 576-595), Publisher: Springer

Status:
Published

DOI:
10.1007/s12035-022-03087-9 – link to the publication

« New search

Projects search