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Information on the principal investigator and host institution

Information of the project and the call

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The effect of chronic treatment with iasenapine and iloperidone on the expression and activity of cytochrome P450 in the brain and liver

2018/31/N/NZ7/01857

Keywords:

cytochrome P450 neuroleptic brain liver rat

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Przemysław Danek 

Number of co-investigators in the project: 3

Call: PRELUDIUM 16 - announced on 2018-09-14

Amount awarded: 209 720 PLN

Project start date (Y-m-d): 2019-06-21

Project end date (Y-m-d): 2023-06-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. 0.
  2. 1.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (6)
  1. The Novel Atypical Antipsychotic Lurasidone Affects Cytochrome P450 Expression in the Liver and Peripheral Blood Lymphocytes
    Authors:
    Przemysław Jan Danek, Władysława Anna Daniel
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 23(23), strony: 16796), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms242316796 - link to the publication
  2. Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms
    Authors:
    Przemysław Jan Danek, Władysława Anna Daniel
    Academic press:
    cells (rok: 2021, tom: 10(12), strony: 3472), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10123472 - link to the publication
  3. The Atypical Antipsychotic Lurasidone Affects Brain but Not Liver Cytochrome P450 2D (CYP2D) Activity. A Comparison with Other Novel Neuroleptics and Significance for Drug Treatment of Schizophrenia
    Authors:
    Przemysław Jan Danek, Władysława Anna Daniel
    Academic press:
    Cells (rok: 2022, tom: 11(21), strony: 3513), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11213513 - link to the publication
  4. The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms
    Authors:
    Przemysław Jan Danek, Wojciech Kuban, Władysława Anna Daniel
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(16), strony: 8447), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22168447 - link to the publication
  5. The Influence of Long-Term Treatment with Asenapine on Liver Cytochrome P450 Expression and Activity in the Rat. The Involvement of Different Mechanisms
    Authors:
    Przemysław Jan Danek, Ewa Bromek, Władysława Anna Daniel
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14(7), strony: 629), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14070629 - link to the publication
  6. Chronic treatment with asenapine affects cytochrome P450 2D (CYP2D) in rat brain and liver. Pharmacological aspects
    Authors:
    Przemysław Jan Danek, Ewa Bromek, Anna Haduch, Władysława Anna Daniel
    Academic press:
    Neurochemistry International (rok: 2021, tom: 151, strony: 105209), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2021.105209 - link to the publication
  1. The effect of chronic treatment with the asenapine on the cytochrome P450 2D (CYP2D) activity in different brain areas
    Authors:
    Danek P.J., Daniel W.A.
    Conference:
    ECNP Workshop for Early Career Scientists in Europe (rok: 2020, ), Wydawca: Elsevier
    Data:
    konferencja 5-8 Marzec
    Status:
    Published
  2. Chronic treatment with iloperidone affects the cytochrome P450 2D (CYP2D) protein and activity in the brain and liver
    Authors:
    Przemysław Jan Danek, Władysława Anna Daniel
    Conference:
    34 ECNP Congress (rok: 2021, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 2-5.10.2021
    Status:
    Published
  3. Comparative study on the effects of chronic treatment with the atypical antipsychotic drug lurasidone on cytochrome P450 enzymes in rat liver and lymphocytes
    Authors:
    Danek P.J., Daniel W.A.
    Conference:
    5th Central European Biomedical Congress "Future trends in health interventions" (rok: 2023, ), Wydawca: CEBC
    Data:
    konferencja 29.05-1.06.2023
    Status:
    Published
  4. The influence of new neuroleptic and antidepressant drugs on brain and liver cytochrome P450 2D (CYP2D)
    Authors:
    Przemysław Jan Danek, Ewa Bromek, Anna Haduch, Władysława Anna Daniel
    Conference:
    22nd INTERNATIONAL CONFERENCE ON CYTOCHROME P450 (rok: 2022, ), Wydawca: ICCP450
    Data:
    konferencja 17-21.07.2022
    Status:
    Published
  5. The effect of chronic treatment with atypical neuroleptic asenapine on the neuroendocrine regulation of liver cytochrome P450
    Authors:
    Danek Przemysław J., Daniel Władysława A.
    Conference:
    4th Central European Biomedical Congress The impact of bioinformatics and omics on biology and medicine (rok: 2021, ), Wydawca: CEBC
    Data:
    konferencja 7-9 czerwiec
    Status:
    Published
  6. Chronic treatment with the atypical neuroleptic asenapine decreases the cytochrome P450 expression and activity in the liver
    Authors:
    Danek P.J., Daniel W.A.
    Conference:
    33rd ECNP Congress Virtual (rok: 2020, ), Wydawca: Elsevier
    Data:
    konferencja 12-15 września
    Status:
    Published

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