Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Badanie funkcji białek homologicznych do czynników wzrostu fibroblastów (FHF)

2018/31/B/NZ3/01656

Keywords:

fibroblast growth factors (FGFs) fibroblast growth factor homologous factors (FHFs) FGF receptors (FGFRs) protein function signalling internalization protein-protein interactions interactome apoptosis protein trafficking secretion

Descriptors:

  • NZ3_1:
  • NZ3_7:
  • NZ3_3:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Małgorzata Urszula Zakrzewska 

Number of co-investigators in the project: 11

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 298 200 PLN

Project start date (Y-m-d): 2019-07-08

Project end date (Y-m-d): 2023-10-07

Project duration:: 51 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (1)
  1. FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization
    Authors:
    Pozniak M, Sokolowska-Wedzina A, Jastrzebski K, Szymczyk J, Porębska N, Krzyścik M, Zakrzewska M, Miączynska M, Otlewski J, Opaliński Ł
    Academic press:
    Molecular Oncology (rok: 2020, tom: 14(9), strony: 1998-2021), Wydawca: FEBS Press/Wiley
    Status:
    Published
    DOI:
    10.1002/1878-0261.12740 - link to the publication
  2. FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner
    Authors:
    Sochacka M, Opaliński Ł, Szymczyk J, Zimoch M, Czyrek A, Krowarsch D, Otlewski J, Zakrzewska
    Academic press:
    Cell Communication and Signaling (rok: 2020, tom: 18(1):69, strony: 45668), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-020-00573-2 - link to the publication
  3. FGF12: biology and function
    Authors:
    Biadun M, Karelus R, Krowarsch D, Opalinski L, Zakrzewska M.
    Academic press:
    Differentiation (rok: 2023, tom: -, strony: 100740), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.diff.2023.100740 - link to the publication
  4. The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells
    Authors:
    Poźniak M, Porębska N, Krzyścik MA, Sokołowska-Wędzina A, Jastrzębski K, Sochacka M, Szymczyk J, Zakrzewska M, Otlewski J, Opaliński Ł.
    Academic press:
    Molecular Medicine (rok: 2021, tom: May 7;27(1), strony: 46), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s10020-021-00306-2 - link to the publication
  5. FGF12: biology and function
    Authors:
    Biadun M, Karelus R, Krowarsch D, Opalinski L, Zakrzewska M.
    Academic press:
    Differentiation (rok: 2023, tom: -, strony: 100740), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.diff.2023.100740 - link to the publication
  6. The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex
    Authors:
    Gedaj A., Chorazewska A., Ciura K., Karelus R., Zukowska D., Biadun M., Kalka M., Zakrzewska M., Porebska N., Opalinski L
    Academic press:
    Cell Communication and Signaling (rok: 2024, tom: 22(1), strony: 175), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-024-01558-1. - link to the publication
  7. FGF homologous factors are secreted from cells to induce FGFR-mediated anti-apoptotic response
    Authors:
    Biadun M, Sochacka M, Karelus R, Baran K, Czyrek A, Otlewski J, Krowarsch D, Opalinski L, Zakrzewska M.
    Academic press:
    The FASEB Journal (rok: 2023, tom: 37(7), strony: e23043), Wydawca: Wiley on behalf of the Federation of American Societies for Experimental Biology
    Status:
    Published
    DOI:
    10.1096/fj.202300324R - link to the publication
  8. FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner
    Authors:
    Sochacka M, Opaliński Ł, Szymczyk J, Zimoch M, Czyrek A, Krowarsch D, Otlewski J, Zakrzewska
    Academic press:
    Cell Communication and Signaling (rok: 2020, tom: 18(1):69, strony: 45668), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-020-00573-2 - link to the publication
  9. FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex
    Authors:
    Sochacka M, Karelus R, Opalinski L, Krowarsch D, Biadun M, Otlewski J, Zakrzewska M.
    Academic press:
    Cell Communication and Signaling (rok: 2022, tom: 2022 Nov 21;20(1), strony: 182), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12964-022-01000-4 - link to the publication
  10. Galectins as modulators of receptor tyrosine kinases signaling in health and disease
    Authors:
    Porębska N, Poźniak M, Matynia A, Żukowska D, Zakrzewska M, Otlewski J, Opaliński Ł.
    Academic press:
    Cytokine & Growth Factor Reviews (rok: 2021, tom: Aug;60:, strony: 89-106), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cytogfr.2021.03.004. - link to the publication
  11. FGF homologous factors are secreted from cells to induce FGFR-mediated anti-apoptotic response
    Authors:
    Biadun M, Sochacka M, Karelus R, Baran K, Czyrek A, Otlewski J, Krowarsch D, Opalinski L, Zakrzewska M.
    Academic press:
    The FASEB Journal (rok: 2023, tom: 37(7), strony: e23043), Wydawca: Wiley on behalf of the Federation of American Societies for Experimental Biology
    Status:
    Published
    DOI:
    10.1096/fj.202300324R - link to the publication
  1. FHFs are unconventionally secreted through a mechanism similar to that of FGF2
    Authors:
    Biadun M., Sochacka M., Krowarsch D., Opalinski L., Zakrzewska M.
    Conference:
    The 47th FEBS Congress (rok: 2023, ), Wydawca: Federation of European Biochemical Societies, Wiley
    Data:
    konferencja 8-12.07.2023
    Status:
    Published

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