Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Interactions of statins with biological membranes - implications for drug delivery research.

2018/31/B/ST4/00406

Keywords:

statins model biological membranes drug carriers cubosomes

Descriptors:

  • ST4_2: Spectroscopic and spectrometric techniques
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Renata Bilewicz 

Number of co-investigators in the project: 6

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 298 900 PLN

Project start date (Y-m-d): 2019-07-04

Project end date (Y-m-d): 2023-01-03

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. komputer (4 336 PLN)
  2. potencjostat (87 376 PLN)
  3. Bipotencjostat (120 000 PLN)
  4. drukarka (1 822 PLN)
  5. Zestaw komputerowy z drukarką (6 636 PLN)
  6. licencja na oprogramowanie (311 PLN)
  7. potencjostat (71 790 PLN)
  8. termostat cyrkulacyjny (44 930 PLN)
  9. Podstawa stołu optycznego z izolacją (3 727 PLN)
  10. Spektormetr IR (200 000 PLN)
  11. System oczyszczania powietrza do pomiarów w podczerwieni (43 188 PLN)
  12. lodówka (3 533 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Incorporation of simvastatin into lipid membranes: Why deliver a statin in form of inclusion complex with hydrophilic cyclodextrin
    Authors:
    Aleksandra Bartkowiak, Dorota Matyszewska, Agata Krzak, Michalina Zaborowska, Marcin Broniatowski, Renata Bilewicz
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2021, tom: 204, strony: 111784), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2021.111784 - link to the publication
  2. Structural modifications of lipid membranes exposed to statins – Langmuir monolayer and PM-IRRAS study
    Authors:
    M. Zaborowska, M. Broniatowski, P. Wydro, D. Matyszewska, R. Bilewicz
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 313, strony: 113570), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.113570 - link to the publication
  3. Designing a Useful Lipid Raft Model Membrane for Electrochemical and Surface Analytical Studies
    Authors:
    Michalina Zaborowska, Damian Dziubak, Dorota Matyszewska, Slawomir Sek, Renata Bilewicz
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 5483), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26185483 - link to the publication
  4. Statin Action Targets Lipid Rafts of Cell Membranes: GIXD/PM-IRRAS Investigation of Langmuir Monolayers.
    Authors:
    Michalina Zaborowska, Marcin Broniatowski, Philippe Fontaine, Renata Bilewicz, Dorota Matyszewska
    Academic press:
    Journal of Physical Chemistry B (rok: 2023, tom: 127, strony: 7135−7147), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.3c02574 - link to the publication
  5. Adjusting the Structure of β-Cyclodextrin to Improve Complexation of Anthraquinone-Derived Drugs
    Authors:
    Agata Krzak, Olga Swiech, Maciej Majdecki, Piotr Garbacz, Paulina Gwardys, Renata Bilewicz
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 7205), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26237205 - link to the publication
  6. Simvastatin Coadministration Modulates the Electrostatically Driven Incorporation of Doxorubicin into Model Lipid and Cell Membranes
    Authors:
    Aleksandra Bartkowiak, Ewa Nazaruk, Ewa Gajda, Marlena Godlewska, Damian Gaweł, Elżbieta Jabłonowska, Renata Bilewicz
    Academic press:
    ACS Biomaterials Science & Engineering (rok: 2022, tom: 8, strony: 4354−4364), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsbiomaterials.2c00724 - link to the publication
  7. Surface and electrochemical properties of lipid raft model membranes and how they are affected by incorporation of statin
    Authors:
    Michalina Zaborowska, Damian Dziubak, Dorota Matyszewska, Renata Bilewicz
    Academic press:
    Electrochimica Acta (rok: 2021, tom: 386, strony: 138514), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.electacta.2021.138514 - link to the publication

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