Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Dual ionophores as multitarget agents against pancreatic cancer

2018/31/B/NZ7/02122

Keywords:

iron chelators anticancer pancreatic cancer multitarget design

Descriptors:

  • NZ7_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

UNIWERSYTET ŚLĄSKI, Wydział Matematyki, Fizyki i Chemii

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Robert Musioł 

Number of co-investigators in the project: 6

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 622 000 PLN

Project start date (Y-m-d): 2019-07-22

Project end date (Y-m-d): 2024-07-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  1. Styrylquinazoline derivatives as ABL inhibitors selective for different DFG orientations
    Authors:
    K. Malarz, J. Mularski, M. Pacholczyk, R. Musiol
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2023, tom: 38, strony: 2201410), Wydawca: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2023.2201410 - link to the publication
  2. Chemistry towards Biology—Instruct: Snapshot
    Authors:
    Hricovíni, M.; Owens, R.J.; Bak, A.; Kozik, V.; Musiał, W.; Pierattelli, R.; Májeková, M.; Rodríguez, Y.; Musioł, R.; Slodek, A.; Štarha, P.; Piętak, K.; Słota, D.; Florkiewicz, W.; Sobczak-Kupiec, A.; Jampílek
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1485-), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232314815 - link to the publication
  3. The Landscape of the Anti-Kinase Activity of the IDH1 Inhibitors
    Authors:
    Malarz, K.; Mularski, J.; Pacholczyk, M.; Musiol, R.
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 536), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12030536 - link to the publication
  4. Anticancer potential and through study of the cytotoxicity mechanism of ionic liquids that are based on the trifluoromethanesulfonate and bis(trifluoromethylsulfonyl)imide anions
    Authors:
    M. Kuczak, M. Musial, K. Malarz, R. Rurka. E. Zorebski, R. Musiol, M. Dzida, A. Mrozek-wilczkiewicz
    Academic press:
    Journal of Hazardous Materials (rok: 2022, tom: 427, strony: 128160), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jhazmat.2021.128160 - link to the publication
  5. The Usefulness of X-ray Diffraction and Thermal Analysis to Study Dietary Supplements Containing Iron
    Authors:
    I. Jendrzejewska, R. Musiol, T. Goryczka, E. Pietrasik, J. Klimontko, J. Jampilek
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 197-222), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27010197 - link to the publication
  6. Acid selective pro-dye for cellular compartments.
    Authors:
    B. Czaplińska, K. Malarz, A. Mrozek-Wilczkiewicz, R. Musiol
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 15304), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-50734-8 - link to the publication
  7. New derivatives of 4′-phenyl-2,2':6′,2″-terpyridine as promising anticancer agents
    Authors:
    K. Malarz, D. Zych, R. Gawecki, M. Kuczak, R. Musioł, A. Mrozek-Wilczkiewicz
    Academic press:
    European Jounal of Medicinal Chemistry (rok: 2020, tom: 189, strony: 19), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2020.113032 - link to the publication
  8. Terpyridines as promising antitumor agents: an overview of their discovery and development
    Authors:
    R. Musiol, P. Malecki, M. Pacholczyk, J. Mularski
    Academic press:
    Expert Opinion on Drug Discovery (rok: 2022, tom: 17, strony: 259-271), Wydawca: Taylor&Francis
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2020.113032 - link to the publication
  9. Antifungal Styryloquinolines as Candida albicans Efflux Pump Inhibitors: Styryloquinolines are ABC Transporter Inhibitors
    Authors:
    W. Cieslik, J. Szczepaniak, A. Krasowska, R. Musiol
    Academic press:
    Molecules (rok: 2021, tom: 25, strony: 345-357), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25020345 - link to the publication
  10. Investigation of Spectrum of Biological Activities of Methoxylated and Methylated 1-Hydroxynaphthalene-2-Carboxanilides
    Authors:
    H. Michnova, S. Pospisilova, T. Gonec, I. Kapustikova, P. Kollar, V. Kozik, R. Musiol, I. Jendrzejewska, J. Vanco, Z. Travnicek, A. Cizek, A. Bak, J. Jampilek
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 2991), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24162991 - link to the publication
  11. Does the change in the length of the alkyl chain bring us closer to the compounds with the expected photophysical and biological properties? – Studies based on D-π-D-A imidazole-phenothiazine system
    Authors:
    S. Zimosz, D. Zych, G. Szafraniec-Gorol, S. Kotowicz, K. Malarz, R. Musiol, A. Słodek
    Academic press:
    Journal of Molecular Liquids (rok: 2022, tom: 365, strony: 120079), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2022.120076 - link to the publication
  12. Efflux systems as a target for anti-biofilm nanoparticles: Perspectives on emerging applications
    Authors:
    R. Musioł
    Academic press:
    Expert Opinion on Therapeutic Targets (rok: 2023, tom: 27, strony: 953-963), Wydawca: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/14728222.2023.2263910 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy