Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Studies on regulation of biosynthesis and on proinflammatory activity of the peptide bacteriocin BaSp222

2018/31/B/NZ3/01226

Keywords:

Bacteriocins virulence factors pro-inflammatory activity posttranslational modifications cytokines cell receptors

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_10: Microbiology
  • NZ1_2: Biochemistry

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Paweł Mak 

Number of co-investigators in the project: 5

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 110 024 PLN

Project start date (Y-m-d): 2019-10-01

Project end date (Y-m-d): 2023-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dwuetapowa odporna chemicznie pompa próżniowa (21 700 PLN)
  2. Wysokociśnieniowy chromatograf cieczowy (zestaw HPLC) (367 770 PLN)
  3. Dwuetapowa olejowa pompa próżniowa (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer
    Authors:
    Śmiałek‑Bartyzel j., Bzowska M., Mężyk‑Kopeć R., Kwissa M., Mak P.
    Academic press:
    Inflammation Research (rok: 2023, tom: 72, strony: 915–928), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00011-023-01721-3 - link to the publication
  2. Structure, Biosynthesis, and Biological Activity of Succinylated Forms of Bacteriocin BacSp222
    Authors:
    Śmiałek J., Nowakowski M., Bzowska M., Bocheńska O., Wlizło A., Kozik A., Dubin G., Mak P.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6256), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126256 - link to the publication
  3. Bacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells 
    Authors:
    Śmiałek J. , Bzowska M. , Hinz A., Mężyk-Kopeć R. , Sołtys K., Mak P.
    Academic press:
    Journal of Inflammation Research (rok: 2022, tom: 15, strony: 4601—4621), Wydawca: Dove Medical Press Ltd
    Status:
    Published
    DOI:
    10.2147/JIR.S362066 - link to the publication

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