Studies on regulation of biosynthesis and on proinflammatory activity of the peptide bacteriocin BaSp222
2018/31/B/NZ3/01226
Keywords
Descriptors
- NZ3_1: Biologia komórki
- NZ1_10: Biologia drobnoustrojów
- NZ1_2: Biochemia
Panel
NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution
Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 5
Call
OPUS 16 – announced on 2018-09-14
- Amount awarded
- 1 110 024 PLN
- Project start date
- 2019-10-01
- Project end date
- 2023-09-30
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Dwuetapowa odporna chemicznie pompa próżniowa. Cost: 21 700 PLN
- Dwuetapowa olejowa pompa próżniowa. Cost: 12 000 PLN
- Wysokociśnieniowy chromatograf cieczowy (zestaw HPLC). Cost: 367 770 PLN
Information in the final report
Publication in academic press/journals (3)
-
BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer
- Authors:
- Śmiałek‑Bartyzel j., Bzowska M., Mężyk‑Kopeć R., Kwissa M., Mak P.
- Academic press:
- Inflammation Research (year: 2023, volume: 72, pages: 915–928), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s00011-023-01721-3 – link to the publication
-
Bacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells
- Authors:
- Śmiałek J. , Bzowska M. , Hinz A., Mężyk-Kopeć R. , Sołtys K., Mak P.
- Academic press:
- Journal of Inflammation Research (year: 2022, volume: 15, pages: 4601—4621), Publisher: Dove Medical Press Ltd
- Status:
- Published
- DOI:
- 10.2147/JIR.S362066 – link to the publication
-
Structure, Biosynthesis, and Biological Activity of Succinylated Forms of Bacteriocin BacSp222
- Authors:
- Śmiałek J., Nowakowski M., Bzowska M., Bocheńska O., Wlizło A., Kozik A., Dubin G., Mak P.
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 6256), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22126256 – link to the publication