Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Mechanistic insights into the specificity of glycosaminoglycan interactions with regulatory proteins

2018/31/G/ST4/00246

Keywords:

protein-glycosaminoglycan interactions specificity electrostatics glycosaminoglycan mimetics nuclear magnetic resonance molecular modeling

Descriptors:

  • ST4_15:
  • ST4_13:
  • ST4_4:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Sergey Samsonov 

Number of co-investigators in the project: 2

Call: BEETHOVEN 3 - announced on 2018-09-14

Amount awarded: 976 500 PLN

Project start date (Y-m-d): 2020-08-31

Project end date (Y-m-d): 2024-05-30

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (14)
  1. Molecular dynamics-based comparative analysis of chondroitin and dermatan sulfates
    Authors:
    Pągielska M., Samsonov S.A.
    Academic press:
    Biomolecules (rok: 2023, tom: 13, strony: 247), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom13020247 - link to the publication
  2. Biglycan Interacts with Type I Insulin-like Receptor (IGF-IR) Signaling Pathway to Regulate Osteosarcoma Cell Growth and Response to Chemotherapy
    Authors:
    Giatagana E-M., Berdiaki A., Gaardløs M., Samsonov S.A., Tzanakakis G.N., Nikitovic D.
    Academic press:
    Cancers (rok: 2022, tom: 14, strony: 1196), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14051196 - link to the publication
  3. The effect of Pd(II) and Pt(II) coordination on the affinity of avibactam to OXA-48 β-lactamase
    Authors:
    Brzeski J., Nowicka P., Samsonov S.A.
    Academic press:
    European Journal of Medicinal Chemistry Reports (rok: 2023, tom: 9, strony: 100118), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmcr.2023.100118 - link to the publication
  4. Benchmarking Water Models in Molecular Dynamics of Protein−Glycosaminoglycan Complexes
    Authors:
    Anila S., Samsonov S.A.
    Academic press:
    Journal of Chemical Information and Modeling (rok: 2024, tom: 64, strony: 1691-1703), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jcim.4c00030 - link to the publication
  5. Role of oligosaccharide chain polarity in protein-glycosaminoglycan interactions.
    Authors:
    Bojarski K.K., Samsonov S.A.
    Academic press:
    J Chem Inf Mod (rok: 2021, tom: 61, strony: 455-466), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jcim.0c01402 - link to the publication
  6. Studying specificity in protein-glycosaminoglycan recognition with umbrella sampling
    Authors:
    Marcicz M., Anila S., Gaardløs M., Zacharias M., Samsonov S.A.
    Academic press:
    Beilstein Journal of Organic Chemistry (rok: 2023, tom: 19, strony: 1933-1946), Wydawca: Beistein Institute
    Status:
    Published
    DOI:
    10.3762/bjoc.19.144 - link to the publication
  7. Extension of the SUGRES-1P Coarse-Grained Model of Polysaccharides to Heparin
    Authors:
    Danielsson A., Samsonov S.A., Liwo A., Sieradzan A.K.
    Academic press:
    Journal of Chemical Theory and Computation (rok: 2023, tom: 17, strony: 6023–6036.), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jctc.3c00511 - link to the publication
  8. Computational modeling of the molecular basis for the calcium-dependence of the mannuronan C-5 epimerase AvAlgE6 from Azotobacter vinelandii
    Authors:
    Gaardløs M., Lervik A., Samsonov S.A.
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2023, tom: 21, strony: 2188-2196), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2023.03.021 - link to the publication
  9. Molecular dynamics-based descriptors of 3-O-Sulfated Heparan sulfate as contributors of protein binding specificity
    Authors:
    Danielsson A., Kogut M.M., Maszota-Zieleniak M., Chopra P., Boons G.J., Samsonov S.A.
    Academic press:
    Computational Biology and Chemistry (rok: 2022, tom: 99, strony: 107716), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.compbiolchem.2022.107716 - link to the publication
  10. Investigation of hexacyanoferrate(II)/(III) charge-dependent interactions with bovine and human serum albumins
    Authors:
    Grabowska O., Samsonov S.A., Chmurzyński L., Wyrzykowski D., Żamojć K.
    Academic press:
    Spectrochimica Acta Part A (rok: 2023, tom: 293, strony: 122505), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2023.122505 - link to the publication
  11. Rapamycin- induced autophagy in osteosarcoma cells is mediated via the biglycan/Wnt/β-catenin signaling axis
    Authors:
    Giatagana E-M., Berdiaki A., Gaardløs M., Tsatsakis A., Samsonov S.A., Nikitovic D.
    Academic press:
    American Journal of Physiology-Cell Physiology (rok: 2022, tom: 323, strony: C1740-C1756), Wydawca: American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpcell.00368.2022 - link to the publication
  12. Ligand Binding of Interleukin-8: A Comparison of Glycosaminoglycans and Acidic Peptides
    Authors:
    Schulze C., Danielsson A., Liwo A., Huster D., Samsonov S.A., Penk A.
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2023, tom: 25, strony: 24930-24947), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d3cp02457a - link to the publication
  13. Role for Carboxylic Acid Moiety in NSAIDs: Favoring the Binding at Site II of Bovine Serum Albumin
    Authors:
    Bertozo L., Tadeu H.S., Sebastian A., Maszota-Zieleniak M., Samsonov S.A., Ximenes V.
    Academic press:
    Molecular Pharmaceutics (rok: 2024, tom: 21, strony: 2501-2511), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.4c00044 - link to the publication
  14. Detecting protein-ligand interactions with nitroxide based paramagnetic cosolutes
    Authors:
    Penk A., Danielsson A., Gaardløs M., Montag C., Schöler A., Huster D., Samsonov S.A., Künze G.
    Status:
    Accepted for publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy