Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of trans-Golgi in regulation of amino acid transporters activity.

2018/30/E/NZ1/00605

Keywords:

amino acids transport trans-Golgi

Descriptors:

  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dawid Krokowski 

Number of co-investigators in the project: 5

Call: SONATA BIS 8 - announced on 2018-06-15

Amount awarded: 3 475 420 PLN

Project start date (Y-m-d): 2019-07-01

Project end date (Y-m-d): 2025-06-30

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation
    Authors:
    Kenneth T Farabaugh, Dawid Krokowski, Bo-Jhih Guan, Zhaofeng Gao, Xing-Huang Gao, Jing Wu, Raul Jobava, Greeshma Ray, Tristan J de Jesus, Massimiliano G Bianchi, Evelyn Chukwurah, Ovidio Bussolati, Michael Kilberg, David A Buchner, Ganes C Sen, Calvin Cotton, Christine McDonald, Michelle Longworth , Parameswaran Ramakrishnan, Maria Hatzoglou
    Academic press:
    eLife (rok: 2020, tom: 9, strony: e52241), Wydawca: eLife Sciences Publications Ltd
    Status:
    Published
    DOI:
    10.7554/eLife.52241 - link to the publication
  2. Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics
    Authors:
    A Blumental-Perry, R Jobava, I Bederman, A J Degar, H Kenche, B J Guan, K Pandit, N A Perry, N D Molyneaux, J Wu, E Prendergas, Z-W Ye, J Zhang, C E Nelson, F Ahangari, D Krokowski, S H Guttentag, P A Linden, D M Townsend, A Miron, M-J Kang, N Kaminski, Y Perry, M Hatzoglou
    Academic press:
    communications biology (rok: 2020, tom: 3, strony: 262), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s42003-020-01322-4 - link to the publication
  3. Identification of a novel alternatively spliced isoform of the ribosomal uL10 protein
    Authors:
    Kamil Filipek, Kamil Deryło, Barbara Michalec-Wawiórka, Monika Zaciura, Alan González-Ibarra, Dawid Krokowski, Przemysław Latoch, Agata L Starosta, Jakub Czapiński, Adolfo Rivero-Müller, Leszek Wawiórka, Marek Tchórzewski
    Academic press:
    Biochim Biophys Acta Gene Regul Mech . (rok: 2022, tom: 1866, strony: 194890), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2022.194890 - link to the publication
  4. Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
    Authors:
    Raul Jobava , Yuanhui Mao , Bo-Jhih Guan , Di Hu , Dawid Krokowski , Chien-Wen Chen , Xin Erica Shu , Evelyn Chukwurah , Jing Wu , Zhaofeng Gao , Leah L Zagore , William C Merrick , Aleksandra Trifunovic , Andrew C Hsieh , Saba Valadkhan , Youwei Zhang , Xin Qi , Eckhard Jankowsky, Ivan Topisirovic , Donny D Licatalosi, Shu-Bing Qian, Maria Hatzoglou
    Academic press:
    Molecular Cell (rok: 2021, tom: 81, strony: 4191-4208), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.molcel.2021.09.029 - link to the publication
  5. Discovery of a Redox Thiol Switch: Implications for Cellular Energy Metabolism
    Authors:
    Xing-Huang Gao, Ling Li, Marc Parisien, Jing Wu, Ilya Bederman, Zhaofeng Gao, Dawid Krokowski, Steven M Chirieleison, Derek Abbott, Benlian Wang, Peter Arvan, Mark Cameron , Mark Chance , Belinda Willard, Maria Hatzoglou
    Academic press:
    Molecular and cellular Proteomics (rok: 2020, tom: 19, strony: 852-870), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/mcp.RA119.001910 - link to the publication
  6. Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
    Authors:
    Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M.
    Academic press:
    Cell Reports (rok: 2022, tom: 40, strony: 111092), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2022.111092. - link to the publication

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