Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Understanding pathophysiological implications of Pf1-like bacteriophages in biopolymer networks that form at the site of infection

2018/30/M/NZ6/00502

Keywords:

Pf1-like bacteriophages antibacterial peptides Pseudomonas aeruginosa rheology

Descriptors:

  • NZ6_8: Other related subjects

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Robert Bucki 

Number of co-investigators in the project: 9

Call: HARMONIA 10 - announced on 2018-06-15

Amount awarded: 1 056 860 PLN

Project start date (Y-m-d): 2019-04-30

Project end date (Y-m-d): 2023-10-29

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (5)
  1. Two lineages of Pseudomonas aeruginosa filamentous phages - structural uniformity over integration preferences
    Authors:
    Fiedoruk K, Zakrzewska M, Daniluk T, Piktel E, Chmielewska S, Bucki R
    Academic press:
    Genome Biology and Evolution (rok: 2020, tom: 12, strony: 1765-1781), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/gbe/evaa146 - link to the publication
  2. Modulation of Biofilm Mechanics by DNA Structure and Cell Type
    Authors:
    Łysik D, Deptuła P, Chmielewska S, Skłodowski K, Pogoda K, LiKang Ch, Song D, Mystkowska J, Janmey PA, Bucki R
    Academic press:
    ACS Biomechanicals Science and Engineering (rok: 2022, tom: 8, strony: 4921-4929), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acsbiomaterials.2c00777 - link to the publication
  3. N-acetyl-cysteine increases activity of peanut-shaped gold nanoparticles against biofilms formed by clinical strains of Pseudomonas aeruginosa isolated from sputum of cystic fibrosis patients
    Authors:
    Piktel E, Wnorowska U, Depciuch J, Łysik D, Cieśluk M, Fiedoruk K, Mystkowska J, Parlińska-Wojtan M, Janmey PA, Bucki R
    Academic press:
    Infection and Drug Resistance (rok: 2022, tom: 15, strony: 851-871), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IDR.S348357 - link to the publication
  4. Nanomechanics and histopathology as diagnostic tools to characterize freshly removed human brain tumors
    Authors:
    Cieśluk M, Pogoda K, Deptuła P, Werel P, Kułakowska A, Kochanowicz J, Mariak Z, Łysoń T, Reszeć J, Bucki R
    Academic press:
    International Journal of Nanomedicine (rok: 2020, tom: 15, strony: 7509-7521), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IJN.S270147 - link to the publication
  5. Biofilm growth causes damage to silicone voice prostheses in patients after surgical treatment of locally advanced laryngeal cancer
    Authors:
    Spałek J, Deptuła P, Cieśluk M, Strzelecka A, Łysik D, Mystkowska J, Daniluk T, Król G, Góźdź S, Bucki R, Durnaś B, Okła S
    Academic press:
    Pathogens (rok: 2020, tom: 9, strony: 0), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pathogens9100793 - link to the publication
  6. Expression and Function of Host Defense Peptides at Inflammation Sites
    Authors:
    Prasad SV, Fiedoruk K, Daniluk T, Piktel E, Bucki R
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 23 pp.), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21010104 - link to the publication
  7. Inhomogeneity of stiffness and density of the extracellular matrix within the leukoplakia of human oral mucosa as potential physicochemical factors leading to carcinogenesis
    Authors:
    Pogoda K, Cieśluk M, Deptuła P, Tokajuk G, Piktel E, Krol G, Reszeć J, Bucki R
    Academic press:
    Translational Oncology (rok: 2021, tom: 14, strony: 9pp, Article ID 101105), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tranon.2021.101105 - link to the publication
  8. Bacteria residing at root canals can induce cell proliferation and alter the mechanical properties of gingival and cancer cells
    Authors:
    Suprewicz Ł, Tokajuk G, Cieśluk M, Deptuła P, Sierpińska T, Wolak P, Wollny T, Tokajuk J, Głuszek S, Piktel E, Bucki R
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 7914), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21217914 - link to the publication
  9. Ceragenins exhibit bactericidal properties that are independent of the ionic strength in the environment mimicking cystic fibrosis sputum
    Authors:
    Skłodowski K, Suprewicz Ł, Chmielewska-Deptuła SJ, Kaliniak Sz, Okła S, Zakrzewska M, Minarowski Ł, Mróz R, Daniluk T, Savage PB, Fiedoruk K, Bucki R
    Academic press:
    Frontiers in Microbiology (rok: 2023, tom: 14, strony: 0), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2023.1290952 - link to the publication
  10. Tissue rheology as a possible complementary procedure to advance histological diagnosis of colon cancer
    Authors:
    Deptuła P, Łysik D, Pogoda K, Cieśluk M, Namiot A, Mystkowska J, Król G, Głuszek S, Janmey PA, Bucki R
    Academic press:
    ACS Biomaterials Science & Engineering (rok: 2020, tom: 6, strony: 5620-5631), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsbiomaterials.0c00975 - link to the publication
  1. Ocena wpływu bakteriofagów nitkowatych na dynamikę wzrostu, tworzenie biofilmu oraz wrażliwość na antybiotyki Pseudomonas aeruginosa
    Authors:
    Zakrzewska M, Fiedoruk K, Daniluk T, Piktel E, Wnorowska U, Bucki R
    Conference:
    XXIX Ogólnopolski Zjazd Polskiego Towarzystwa Mikrobiologów (rok: 2022, ), Wydawca: Polskie Towarzystwo Mikrobiologów
    Data:
    konferencja 15-17.09.2022
    Status:
    Published
  2. Susceptibility of bacteriophage-producing Pseudomonas aeruginosa isolated from cystic fibrosis sputum to ceragenins
    Authors:
    Piktel E, Wnorowska U, Zakrzewska M, Fiedoruk K, Bucki R
    Conference:
    41st Annual Meeting of the European Society For Paediatric Infectious Diseases (rok: 2023, ), Wydawca: ESPID
    Data:
    konferencja 8-12.05.2023
    Status:
    Published
  3. Influence of Pseudomonas aeruginosa filamentous phages on the immune response of human lung epithelial cells
    Authors:
    Fiedoruk K, Zakrzewska M, Piktel E, Wnorowska U, Daniluk T, Bucki R
    Conference:
    41st Annual Meeting of the European Society For Paediatric Infectious Diseases (rok: 2023, ), Wydawca: ESPID
    Data:
    konferencja 8-12.05.2023
    Status:
    Published
  4. Prevalence and variation of filamentous phages in Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis (CF)
    Authors:
    Zakrzewska M, Fiedoruk K, Piktel E, Daniluk T, Wnorowska U, Chmielewska S, Deptuła P, Cieśluk M, Bucki R
    Conference:
    XXIII Sympozjum Postępy w Medycynie Zakażeń (rok: 2019, ), Wydawca: Fundacja Centrum Mikrobiologii Klinicznej
    Data:
    konferencja 6-7.12.2019
    Status:
    Published
  5. The activity of ceragenin CSA-13 against multispecies biofilms associated with chronic infections in cystic fibrosis subjects
    Authors:
    Wnorowska U, Łysik D, Piktel E, Zakrzewska M, Daniluk T, Fiedoruk K, Bucki R
    Conference:
    41st Annual Meeting of the European Society For Paediatric Infectious Diseases (rok: 2023, ), Wydawca: ESPID
    Data:
    konferencja 8-12.05.2023
    Status:
    Published

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