Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Ascending control of the interpeduncular nucleus - the role of nucleus incertus-interpeduncular neural network in novelty preference and novelty-to-familiarity transition; ex vivo and behavioural studies

2018/30/E/NZ4/00687

Keywords:

interpeduncular nucleus nucleus incertus novelty preference stress

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Błasiak 

Number of co-investigators in the project: 5

Call: SONATA BIS 8 - announced on 2018-06-15

Amount awarded: 3 029 448 PLN

Project start date (Y-m-d): 2019-10-01

Project end date (Y-m-d): 2025-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (16)
  • Book publications / chapters in book publications (1)
  1. Catecholaminergic innervation and D2-like dopamine receptor-mediated modulation of brainstem nucleus incertus neurons in the rat
    Authors:
    Szlaga Agata, Sambak Patryk, Guguła Anna, Trenk Aleksandra, Gundlach Andrew L., Blasiak Anna
    Academic press:
    Neuropharmacology (rok: 2022, tom: 218, strony: 109216), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2022.109216 - link to the publication
  2. Functional Neuroanatomy of the Rat Nucleus Incertus–Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway
    Authors:
    Agata Szlaga, Patryk Sambak, Aleksandra Trenk, Anna Gugula, Caitlin E. Singleton, Gniewosz Drwiega, Tomasz Blasiak, Sherie Ma, Andrew L. Gundlach, Anna Blasiak
    Academic press:
    Frontiers in cellular neuroscience (rok: 2022, tom: 16, strony: 836116), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fncel.2022.836116 - link to the publication
  3. Bidirectional Communication between the Pontine Nucleus Incertus and the Medial Septum Is Carried Out by Electrophysiologically-Distinct Neuronal Populations
    Authors:
    Aleksandra Trenk, Magdalena Walczak, Agata Szlaga, Kamil Pradel, Anna Blasiak and Tomasz Blasiak
    Academic press:
    The Journal of Neuroscience (rok: 2022, tom: 42, strony: 2234-2252), Wydawca: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.0230-21.2022 - link to the publication
  4. Early life stress-induced alterations in the activity and morphology of ventral tegmental area neurons in female rats
    Authors:
    Jadwiga Spyrka, Anna Gugula, Agnieszka Rak, Grzegorz Tylko, Grzegorz Hess, Anna Blasiak
    Academic press:
    Neurobiology of stress (rok: 2020, tom: 13, strony: 100250), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ynstr.2020.100250 - link to the publication
  5. Early-life Stress Modifies the Reactivity of Neurons in the Ventral Tegmental Area and Lateral Hypothalamus to Acute Stress in Female Rats
    Authors:
    Anna Gugula, Aleksandra Trenk, Aleksandra Celary, Katarzyna Cizio, Grzegorz Tylko, Anna Blasiak*, Grzegorz Hess*, * corresponding authors
    Academic press:
    Neuroscience (rok: 2022, tom: 490, strony: 49-65), Wydawca: IBRO
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2022.02.017 - link to the publication
  6. Relaxin ligand/receptor systems in the developing teleost fish brain : conserved features with mammals and a platform to address neuropeptide system functions
    Authors:
    Blasiak Anna, Gugula Anna, Gundlach Andrew L., Olucha-Bordonau Francisco E., Aniello Francesco, Donizetti Aldo
    Academic press:
    Frontiers in Molecular Neuroscience (rok: 2022, tom: 15, strony: 10.3389/fnmol.2022.984524), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnmol.2022.984524 - link to the publication
  1. Dopaminergic D1 receptor signaling in the midbrain interpeduncular nucleus – possible involvement in control of novelty preference expression
    Authors:
    Szlaga A, Sambak P, Gugula A, Blasiak A
    Conference:
    FENS Regional Meeting 2021 (rok: 2021, ), Wydawca: FENS
    Data:
    konferencja 25.08-27.08
    Status:
    Published
  2. Interpeduncular nucleus neurons innervated by nucleus incertus are sensitive to nicotine – a new neuronal substrate for the influence of stress on novelty preference
    Authors:
    Gabriela Stopka, Patryk Sambak and Anna Blasiak
    Conference:
    12th Neuronus 2022 Neuroscience Forum (rok: 2022, ), Wydawca: NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY PAS WARSAW, POLAND
    Data:
    konferencja 15.10-17.10
    Status:
    Published
  3. Single interpeduncular nucleus cells integrate cholinergic and relaxin-3 signaling – possible role in familiarity/novelty and stress processing.
    Authors:
    G. Stopka, P. Sambak, A. Trenk, A. Gugula, A. Kaleta, A. Gundlach, M. Hossain, A. Blasiak
    Conference:
    IBRO Neuroscience Reports (rok: 2023, ), Wydawca: IBRO - International Brain Research Organization
    Data:
    konferencja 09-13.09.2023
    Status:
    Published
    DOI:
    link to the publication
  4. THE INTERPLAY OF NEUROPEPTIDES IN SHAPING NEURONAL ACTIVITY – OXYTOCIN AND RELAXIN-3 IN THE CONTROL OF HIPPOCAMPUS DENTATE GYRUS ACTIVITY – HUMAN AND RAT STUDIES
    Authors:
    A. Trenk, K. Przybylska, A. Gugula, C. De Ávila, M. Hossain, A. Intorcia, G. Serrano, T. Beach, D. Mastroeni, A. Gundlach, A. Blasiak.
    Conference:
    IBRO 2023 - IBRO World Congress of Neuroscience (rok: 2023, ), Wydawca: IBRO - International Brain Research Organization
    Data:
    konferencja 09-13.09.2023
    Status:
    Published
    DOI:
    link to the publication
  5. The effects of RXFP3 receptor activation on neuronal activity of the rat ventral hippocampus - ex vivo studies
    Authors:
    Kinga Przybylska, Aleksandra Trenk, Anna Gugula and Anna Blasiak
    Conference:
    12th Neuronus 2022 Neuroscience Forum (rok: 2022, ), Wydawca: NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY PAS WARSAW, POLAND
    Data:
    konferencja 15.10-17.10
    Status:
    Published
  6. UNCOVERING THE NEURONAL MECHANISM UNDERLYING EARLY-LIFE STRESS RELATED IMPAIRMENTS – THE POSSIBLE ROLE OF NUCLEUS INCERTUS IN MATERNAL SEPARATION INDUCED INCREASED STRESS SENSITIVITY
    Authors:
    Aleksandra Nogaj, Anna Gugula, Patryk Sambak, Aleksandra Trenk, Anna Blasiak
    Conference:
    IBRO 2023 - IBRO World Congress of Neuroscience (rok: 2023, ), Wydawca: IBRO - International Brain Research Organization
    Data:
    konferencja 09-13.09.2023
    Status:
    Published
    DOI:
    link to the publication
  7. oint modulation of interpeduncular nucleus neurons activity by NGF and relaxin-3 - possible role in control of stress and anxiety related behaviours
    Authors:
    Sylwia Drabik, Aleksandra Trenk, Anna Guguła, Patryk Sambak, Angelika Kaleta, Gabriela Stopka, Anna Błasiak
    Conference:
    IBRO 2023 - IBRO World Congress of Neuroscience (rok: 2023, ), Wydawca: IBRO - International Brain Research Organization
    Data:
    konferencja 09-13.09.2023
    Status:
    Published
    DOI:
    link to the publication
  8. DOPAMINERGIC MODULATION OF NUCLEUS INCERTUS TO INTERPEDUNCULAR NUCLEUS INPUT – A POSSIBLE NEURONAL MECHANISM FOR STRESS-INDUCED NOVELTY PREFERENCE DEFICIENCIES
    Authors:
    Agata Szlaga, Patryk Sambak, Anna Blasiak
    Conference:
    FENS Forum 2022 (rok: 2022, ), Wydawca: FENS
    Data:
    konferencja 09.07-13.07
    Status:
    Published
  9. Dentate gyrus of the ventral hippocampus under control of brainstem nucleus incertus - electrophysiological, anatomical and neurochemical studies in rat
    Authors:
    Aleksandra Trenk, Kinga Przybylska, Anna Gugula, Camila de Avila Dal'Bo, Sylwia Drabik, Magdalena Walczak, Angelika Kaleta, Mohammed Akhter Hossain, John D. Fryer, Andrew L. Gundlach and Anna Blasiak
    Conference:
    FENS Forum 2022 (rok: 2022, ), Wydawca: FENS
    Data:
    konferencja 09.07-13.07
    Status:
    Published
  10. EARLY-LIFE STRESS ALTERS MORPHOLOGY AND STRESS SENSITIVITY OF THE RAT NUCLEUS INCERTUS NEURONS IN A CELL-TYPE-SPECIFIC MANNER
    Authors:
    Anna GugulaPatryk SambakAleksandra TrenkSylwia DrabikAnna Blasiak
    Conference:
    IBRO 2023 - IBRO World Congress of Neuroscience (rok: 2023, ), Wydawca: IBRO - International Brain Research Organization
    Data:
    konferencja 09-13.09.2023
    Status:
    Published
    DOI:
    link to the publication
  11. The possible role of NGF and relaxin-3 modulalation of interpeduncular nucleus in the control of anxiety and stress related behaviours
    Authors:
    Sylwia Drabik, Aleksandra Trenk, Anna Guguła, Patryk Sambak, Angelika Kaleta, Gabriela Stopka, Anna Błasiak
    Conference:
    16th Polish Neurosciety Congress, Torun 2023 (rok: 2023, ), Wydawca: NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY, WARSAW, POLAND
    Data:
    konferencja 20-23.09
    Status:
    Published
  12. A NEW PLAYER IN CONTROL OF VENTRAL HIPPOCAMPUS ACTIVITY; RELAXIN-3/RXFP3 SIGNALING AND RELAXIN-3 INNERVATION OF VENTRAL HIPPOCAMPUS DENTATE GYRUS - HUMAN AND RAT STUDIES
    Authors:
    K. Przybylska, A. Trenk, A. Nogaj, C. De Ávila, M. Hossain, A. Intorcia, G. Serrano, T. Beach, D. Mastroeni, A. Gundlach, A. Blasiak
    Conference:
    IBRO 2023 - IBRO World Congress of Neuroscience (rok: 2023, ), Wydawca: IBRO - International Brain Research Organization
    Data:
    konferencja 09-13.09.2023
    Status:
    Published
    DOI:
    link to the publication
  13. Dentate gyrus of the ventral hippocampus innervation by brainstem nucleus incertus – electrophysiological and anatomical studies in rat
    Authors:
    Aleksandra Nogaj, Aleksandra Trenk, Kinga Przybylska, and Anna Blasiak
    Conference:
    12th Neuronus 2022 Neuroscience Forum (rok: 2022, ), Wydawca: NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY PAS WARSAW, POLAND
    Data:
    konferencja 15.10-17.10
    Status:
    Published
  14. Dissecting neuronal pathways underlying theta rhythmogenesis – evidence for cell-specific involvement of the nucleus incertus-medial septum axis
    Authors:
    Sambak P, Trenk A, Szlaga A, Gundlach AL, Blasiak A
    Conference:
    FENS Regional Meeting 2021 (rok: 2021, ), Wydawca: FENS
    Data:
    konferencja 25.08-27.08
    Status:
    Published
  15. Neurochemical profiles of nucleus incertus neurons and their connections with the medial septum in the rat brain
    Authors:
    Anna Gugula, Aleksandra Trenk, Patryk Sambak, Gniewosz Drwiega, Andrew Gundlach, Anna Blasiak
    Conference:
    FENS Forum 2022 (rok: 2022, ), Wydawca: FENS
    Data:
    konferencja 09.07-13.07
    Status:
    Published
  16. THE INFLUENCE OF THE CHOLINERGIC AND RELAXIN‑3 SIGNALLING ON THE ACTIVITY OF INTERPEDUNCULAR NUCLEUS NEURONS – A POSSIBLE NEURONAL SUBSTRATE FOR THE FAMILIARITY/NOVELTY PROCESSING
    Authors:
    G. Stopka, P. Sambak, A. Trenk, A. Gugula, A. Kaleta, A. Gundlach, M. Hossain, A. Blasiak
    Conference:
    16th Polish Neurosciety Congress, Torun 2023 (rok: 2023, ), Wydawca: NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY, WARSAW, POLAND
    Data:
    konferencja 20-23.09
    Status:
    Published
  1. Functional Neuroanatomy of Relaxin-3/RXFP3 Systems in the Brain: Implications for Integrated Neuroendocrine and Behavioural Control
    Authors:
    Kania Alan, Blasiak Anna, Gundlach Andrew L.
    Book:
    Neuroanatomy of Neuroendocrine Systems (rok: 2021, tom: 12, strony: 487-511), Wydawca: Springer Nature
    Status:
    Published

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