Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Microfluidic methods for quantitative antibiotic susceptibility assays with single cell resolution

2018/30/A/ST4/00036

Keywords:

microfluidics droplets ditigal assays label-free detection single cell bacteria antibiotic susceptibility antibiotic resistance inoculum effect phenotypic heterogeneity

Descriptors:

  • ST4_6: Instrumental methods in chemistry
  • ST3_19:
  • NZ6_4: Bacteriology

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Chemii Fizycznej Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Piotr Garstecki 

Number of co-investigators in the project: 8

Call: MAESTRO 10 - announced on 2018-06-15

Amount awarded: 3 913 400 PLN

Project start date (Y-m-d): 2019-10-01

Project end date (Y-m-d): 2025-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Droplet microfluidics for high-throughput analysis of antibiotic susceptibility in bacterial cells and populations
    Authors:
    Witold Postek, Piotr Garstecki
    Academic press:
    Accounts of Chemical Research (rok: 2022, tom: 55, strony: 605–615), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.accounts.1c00729 - link to the publication
  2. A method for simultaneous polishing and hydrophobization of polycarbonate for microfluidic applications
    Authors:
    Dominika Ogończyk, Paweł Jankowski, Piotr Garstecki
    Academic press:
    Polymers (rok: 2020, tom: 12, strony: 45302), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/polym12112490 - link to the publication
  3. Microfluidic one-pot digital droplet FISH using LNA/DNA molecular beacons for bacteria detection and absolute quantification
    Authors:
    Yu-Ting Kao, Silvia Calabrese, Nadine Borst, Michael Lehnert, Yu-Kai Lai, Franziska Schlenker, Peter Juelg, Roland Zengerle, Piotr Garstecki, Felix von Stetten
    Academic press:
    Biosensors (rok: 2022, tom: 12, strony: 237), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/bios12040237 - link to the publication
  4. You will know by its tail: a method for quantification of heterogeneity of bacterial populations using single-cell MIC profiling
    Authors:
    Natalia Pacocha, Jakub Boguslawski, Karol Makuch, Marta Zapotoczna, Piotr Garstecki
    Academic press:
    Lab on a Chip (rok: 2022, tom: 22, strony: 4317-4326), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2LC00234E - link to the publication
  5. Droplet-based methods for tackling antimicrobial resistance
    Authors:
    Artur Ruszczak, Simona Bartkova, Marta Zapotoczna, Ott Scheler, Piotr Garstecki
    Academic press:
    Current Opinion in Biotechnology (rok: 2022, tom: 76, strony: 102755), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.copbio.2022.102755 - link to the publication
  6. Gold polycarbonate microchannels for electrochemical applications
    Authors:
    D. Ogończyk, P. Jankowski
    Academic press:
    Electroanalaysis (rok: 2023, tom: 35, strony: e202300143), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/elan.202300143 - link to the publication
  7. Physicochemical properties predict retention of antibiotics in water in oil droplets
    Authors:
    Artur Ruszczak, Paweł Jankowski, Shreyas Vasantham, Ott Scheler, Piotr Garstecki
    Academic press:
    Analytical Chemistry (rok: 2023, tom: 95, strony: 1574–1581), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.analchem.2c04644 - link to the publication
  8. Formation of droplets in microfluidic cross-junctions at small Capillary numbers: breakdown of the classical squeezing regime
    Authors:
    Tetuko Kurniawian, Mahsa Sahebdivani, Damian Zaremba, Slawomir Blonski, Piotr Garstecki, Volkert Van Steijn, Piotr Korczyk
    Academic press:
    Chemical Engineering Journal (rok: 2023, tom: 474, strony: 145601), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cej.2023.145601 - link to the publication
  9. Microfluidics for antibiotic susceptibility testing
    Authors:
    Witold Postek, Natalia Pacocha, Piotr Garstecki
    Academic press:
    Lab on a Chip (rok: 2022, tom: 22, strony: 3637-3662), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2LC00394E - link to the publication
  10. Tuna-step: Tunable Parallelized Step Emulsification for the Generation of Droplets with Dynamic Volume Control to 3D Print Functionally Graded Porous Materials
    Authors:
    Francesco Nalin, Maria Celeste Tirelli, Piotr Garstecki, Witold Postek, Marco Costantini
    Academic press:
    Lab on a Chip (rok: 2024, tom: 24, strony: 113-126), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D3LC00658A - link to the publication

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