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Molecular mechanisms of heart failure in Duchenne and Becker muscular dystrophy

2018/30/A/NZ3/00412

Keywords

Descriptors

  • NZ3_8: Komórki macierzyste
  • NZ5_3: Patogeneza chorób człowieka
  • NZ1_1: Biologia molekularna

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Józef Dulak

Number of co-investigators in the project: 9

Call

MAESTRO 10 – announced on 2018-06-15

Amount awarded
3 999 800 PLN
Project start date
2019-05-06
Project end date
2025-10-05
Project duration
60 months (the same as in the proposal)
Project status
Project completed

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (25)

  1. Lack of miR-378 attenuates muscular dystrophy in mdx mice

    Authors:
    Paulina Podkalicka, Olga Mucha, Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz, Anna Cetnarowska, Urszula Głowniak-Kwitek,Karolina Bukowska-Strakova,Maciej Cieśla, Maria Kulecka,Jerzy Ostrowski,Michał Mikuła, Anna Potulska-Chromik, Anna Kostera-Pruszczyk, Alicja Józkowicz, Agnieszka Łoboda, Józef Dulak
    Academic press:
    JCI Insight, Publisher: American Society for Clinical Investigation
    Status:
    Published
    DOI:
    10.1172/jci.insight.135576 – link to the publication

  2. Molekularne mechanizmy dystrofii mięśniowej Duchenne'a i nowe możliwości terapeutyczne

    Authors:
    Paulina Podkalicka, Małgorzata Myszka, Józef Dulak, Agnieszka Łoboda
    Academic press:
    Postępy Biochemii (pages: 109-122), Publisher: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2021_428 – link to the publication

  3. NRF2 Regulates Viability, Proliferation, Resistance to Oxidative Stress, and Differentiation of Murine Myoblasts and Muscle Satellite Cells

    Authors:
    Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz , Magdalena Madej, Alicja Józkowicz, Agnieszka Łoboda, Józef Dulak
    Academic press:
    Cells, Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11203321 – link to the publication

  4. Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future

    Authors:
    Agnieszka Łoboda, Józef Dulak
    Academic press:
    Pharmacological Reports (pages: 1227–1263), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00134-x – link to the publication

  5. The role of Nrf2 in acute and chronic muscle injury

    Authors:
    Iwona Bronisz-Budzyńska , Magdalena Kozakowska, Paulina Podkalicka, Neli Kachamakova-Trojanowska, Agnieszka Łoboda, Józef Dulak
    Academic press:
    Skeletal Muscle, Publisher: BMC Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13395-020-00255-0 – link to the publication

  6. Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research

    Authors:
    Andrysiak K, Stępniewski J, Dulak J.
    Academic press:
    Pflügers Archiv : European journal of physiology (pages: 1061-1085), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00424-021-02536-z – link to the publication

  7. Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1)

    Authors:
    Jelinkova S, Martyniak A, Dulak J, Stępniewski J.
    Academic press:
    Stem Cell Research, Publisher: Elcevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2021.102529 – link to the publication

  8. Generation of microRNA-378a-deficient hiPSC as a novel tool to study its role in human cardiomyocytes

    Authors:
    Martyniak A, Andrysiak K, Motais B, Coste S, Podkalicka P, Ferdek P, Stępniewski J, Dulak J.
    Academic press:
    Journal of Molecular and Cellular Cardiology (pages: 128-141), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.yjmcc.2021.07.007 – link to the publication

  9. Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells

    Authors:
    Paulina Podkalicka, Jacek Stępniewski, Olga Mucha, Neli Kachamakova-Trojanowska , Józef Dulak and Agnieszka Łoboda
    Academic press:
    Biomolecules, Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10121614 – link to the publication

  10. Role of Heme-Oxygenase-1 in Biology of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells.

    Authors:
    Jeż M, Martyniak A, Andrysiak K, Mucha O, Szade K, Kania A, Chrobok Ł, Palus-Chramiec K, Sanetra AM, Lewandowski MH, Pośpiech E, Stępniewski J, Dulak J.
    Academic press:
    Cells, Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10030522 – link to the publication

  11. The multifaceted view of heart problem in Duchenne muscular dystrophy.

    Authors:
    Florczyk-Soluch, U., Polak, K., Dulak, J.
    Academic press:
    Cellular and Molecular Life Sciences (pages: 5447–5468), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-021-03862-2 – link to the publication

  12. Gene therapy. The legacy of Wacław Szybalski.

    Authors:
    Józef Dulak
    Academic press:
    ACTA BIOCHIMICA POLONICA (pages: 359-375), Publisher: Polish Biochemical Society and the Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2020_5805 – link to the publication

  13. Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, in Contrast to Adipose Tissue-Derived Stromal Cells, Efficiently Improve Heart Function in Murine Model of Myocardial Infarction

    Authors:
    Jacek Stepniewski , Mateusz Tomczyk, Kalina Andrysiak , Izabela Kraszewska , Alicja Martyniak , Agnieszka Langrzyk, Klaudia Kulik Ewa Wisniewska,Mateusz Jez, Urszula Florczyk-Soluch, Katarzyna Polak , Paulina Podkalicka, Neli Kachamakova-Trojanowska , Alicja Józkowicz , Agnieszka Jazwa-Kusior and Józef Dulak
    Academic press:
    Biomedicines, Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines8120578 – link to the publication

  14. Adaptation of cardiomyogenesis to the generation and maturation of cardiomyocytes from human pluripotent stem cells

    Authors:
    Martyniak A, Jeż M, Dulak J, Stępniewski J
    Academic press:
    IUBMB Life, Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/iub.2685 – link to the publication

  15. Dysregulated iron homeostasis in dystrophin-deficient cardiomyocytes: correction by gene editing and pharmacological treatment.

    Authors:
    Andrysiak K, Machaj G, Priesmann D, Woźnicka O, Martyniak A, Ylla G, Krüger M, Pyza E, Potulska-Chromik A, Kostera-Pruszczyk A, Łoboda A, Stępniewski J, Dulak J.
    Academic press:
    Cardiovascular Research (pages: 69-81), Publisher: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/cvr/cvad182. – link to the publication

  16. Nuclear Factor Erythroid 2-Related Factor 2 and Its Targets in Skeletal Muscle Repair and Regeneration

    Authors:
    Łoboda A, Dulak J.
    Academic press:
    Antioxidants and Redox Signaling (pages: 619-642), Publisher: Mary Ann Libert Onc
    Status:
    Published
    DOI:
    10.1089/ars.2022.0208 – link to the publication

  17. Proteome Profiling of the Dystrophic mdx Mice Diaphragm

    Authors:
    Mucha O, Myszka M, Podkalicka P, Świderska B, Malinowska A, Dulak J, Łoboda A.
    Academic press:
    Biomolecules, Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biom13111648. – link to the publication

  18. Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia.

    Authors:
    Florczyk-Soluch U, Polak K, Sabo R, Martyniak A, Stępniewski J, Dulak J.
    Academic press:
    Pharmacological Reports (pages: 1556-1570), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-023-00535-8 – link to the publication

  19. Effect of heme oxygenase-1 on the differentiation of human myoblasts and the regeneration of murine skeletal muscles after acute and chronic injury.

    Authors:
    Głowniak-Kwitek U, Caballero AL, Bronisz-Budzyńska I, Kozakowska M, Andrysiak K, Stępniewski J, Łoboda A, Dulak J.
    Academic press:
    Pharamacological Reports (pages: 397-410), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-023-00475-3 – link to the publication

  20. Casein kinase 2 activity is a host restriction factor for AAV transduction

    Authors:
    Kraszewska I, Sarad K, Andrysiak K, Kopacz A, Schmidt L, Krüger M, Dulak J, Jaźwa-Kusior A
    Academic press:
    Molecular Therapy (pages: 84-102), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymthe.2023.11.010 – link to the publication

  21. miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy

    Authors:
    Paulina Podkalicka, Olga Mucha , Katarzyna Kaziród, Krzysztof Szade , Jacek Stępniewski , Liudmyla Ivanishchuk , Hirofumi Hirao, Ewelina Pośpiech, Alicja Józkowicz, Jerzy W Kupiec-Weglinski , Józef Dulak, Agnieszka Łoboda
    Academic press:
    Scientific Reports, Publisher: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41598-022-07868-z – link to the publication

  22. Generation of human induced pluripotent stem cell lines with HMOX1 promoter polymorphism and CRISPR/Cas9-mediated deletion of exon 50 of DMD gene

    Authors:
    Katarzyna Polak, Jacek Stępniewski, Aneta Ścieżyńska, Anna Podgórska , Józef Dulak , Urszula Florczyk-Soluch
    Academic press:
    Stem Cell Research, Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2022.103004 – link to the publication

  23. Targeted expression of heme oxygenase‑1 in satellite cells improves skeletal muscle pathology in dystrophic mice

    Authors:
    Florczyk‑Soluch U, Polak K, Jelinkova S, Bronisz‑Budzyńska I, Sabo R , Bolisetty S, Agarwal A, , Werner E, Józkowicz A, Stepniewski J, Szade K, Dulak J
    Academic press:
    Skeletal Muscle (pages: 14(1):13), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13395‑024‑00346‑2 – link to the publication

  24. Generation of human induced pluripotent stem cell line derived from Becker muscular dystrophy patient with CRISPR/Cas9-mediated correction of DMD gene mutation

    Authors:
    Przymuszała M, Martyniak A, Kwiatkowska J, Meyer-Szary J, Śledzińska K, Wierzba J, Dulak J, Florczyk-Soluch U, Stępniewski J.
    Academic press:
    Stem Cell Research (pages: Apr;76:103327), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2024.103327. – link to the publication

  25. Upregulation of utrophin improves the phenotype of Duchenne muscular dystrophy hiPSC-derived CMs

    Authors:
    Andrysiak K, Ferdek PE, Sanetra AM, Machaj G, Schmidt L, Kraszewska I, Sarad K, Palus-Chramiec K, Lis O, Targosz-Korecka M, Krüger M, Lewandowski MH, Ylla G, Stępniewski J, Dulak J.
    Academic press:
    Molecular Therapy Nucleic Acids (pages: Jun 11;35(3):102247), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.omtn.2024.102247 – link to the publication

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Graphic design and implementation: Jakub Piotrowski