Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular mechanisms of heart failure in Duchenne and Becker muscular dystrophy

2018/30/A/NZ3/00412

Keywords:

induced pluripotent stem cells organoids heart-on-a-chip cardiomyocytes endothelial cells fibroblasts cardiomyopathy mdx mice Hmox1 miR-378a

Descriptors:

  • NZ3_8:
  • NZ5_3:
  • NZ1_1:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Józef Dulak 

Number of co-investigators in the project: 9

Call: MAESTRO 10 - announced on 2018-06-15

Amount awarded: 3 999 800 PLN

Project start date (Y-m-d): 2019-05-06

Project end date (Y-m-d): 2025-05-05

Project duration:: 72 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (25)
  1. Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future
    Authors:
    Agnieszka Łoboda, Józef Dulak
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72, strony: 1227–1263), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00134-x - link to the publication
  2. Dysregulated iron homeostasis in dystrophin-deficient cardiomyocytes: correction by gene editing and pharmacological treatment.
    Authors:
    Andrysiak K, Machaj G, Priesmann D, Woźnicka O, Martyniak A, Ylla G, Krüger M, Pyza E, Potulska-Chromik A, Kostera-Pruszczyk A, Łoboda A, Stępniewski J, Dulak J.
    Academic press:
    Cardiovascular Research (rok: 2024, tom: 120, strony: 69-81), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/cvr/cvad182. - link to the publication
  3. Proteome Profiling of the Dystrophic mdx Mice Diaphragm
    Authors:
    Mucha O, Myszka M, Podkalicka P, Świderska B, Malinowska A, Dulak J, Łoboda A.
    Academic press:
    Biomolecules (rok: 2023, tom: 13, strony: 1648), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom13111648. - link to the publication
  4. miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy
    Authors:
    Paulina Podkalicka, Olga Mucha , Katarzyna Kaziród, Krzysztof Szade , Jacek Stępniewski , Liudmyla Ivanishchuk , Hirofumi Hirao, Ewelina Pośpiech, Alicja Józkowicz, Jerzy W Kupiec-Weglinski , Józef Dulak, Agnieszka Łoboda
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 3945), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41598-022-07868-z - link to the publication
  5. Targeted expression of heme oxygenase‑1 in satellite cells improves skeletal muscle pathology in dystrophic mice
    Authors:
    Florczyk‑Soluch U, Polak K, Jelinkova S, Bronisz‑Budzyńska I, Sabo R , Bolisetty S, Agarwal A, , Werner E, Józkowicz A, Stepniewski J, Szade K, Dulak J
    Academic press:
    Skeletal Muscle (rok: 2024, tom: 14, strony: 14(1):13), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13395‑024‑00346‑2 - link to the publication
  6. Generation of human induced pluripotent stem cell line derived from Becker muscular dystrophy patient with CRISPR/Cas9-mediated correction of DMD gene mutation
    Authors:
    Przymuszała M, Martyniak A, Kwiatkowska J, Meyer-Szary J, Śledzińska K, Wierzba J, Dulak J, Florczyk-Soluch U, Stępniewski J.
    Academic press:
    Stem Cell Research (rok: 2024, tom: 76, strony: Apr;76:103327), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2024.103327. - link to the publication
  7. Lack of miR-378 attenuates muscular dystrophy in mdx mice
    Authors:
    Paulina Podkalicka, Olga Mucha, Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz, Anna Cetnarowska, Urszula Głowniak-Kwitek,Karolina Bukowska-Strakova,Maciej Cieśla, Maria Kulecka,Jerzy Ostrowski,Michał Mikuła, Anna Potulska-Chromik, Anna Kostera-Pruszczyk, Alicja Józkowicz, Agnieszka Łoboda, Józef Dulak
    Academic press:
    JCI Insight (rok: 2020, tom: 5, strony: 135576), Wydawca: American Society for Clinical Investigation
    Status:
    Published
    DOI:
    10.1172/jci.insight.135576 - link to the publication
  8. Molekularne mechanizmy dystrofii mięśniowej Duchenne'a i nowe możliwości terapeutyczne
    Authors:
    Paulina Podkalicka, Małgorzata Myszka, Józef Dulak, Agnieszka Łoboda
    Academic press:
    Postępy Biochemii (rok: 2022, tom: 68, strony: 109-122), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2021_428 - link to the publication
  9. Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells
    Authors:
    Paulina Podkalicka, Jacek Stępniewski, Olga Mucha, Neli Kachamakova-Trojanowska , Józef Dulak and Agnieszka Łoboda
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 1614), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10121614 - link to the publication
  10. Nuclear Factor Erythroid 2-Related Factor 2 and Its Targets in Skeletal Muscle Repair and Regeneration
    Authors:
    Łoboda A, Dulak J.
    Academic press:
    Antioxidants and Redox Signaling (rok: 2023, tom: 38, strony: 619-642), Wydawca: Mary Ann Libert Onc
    Status:
    Published
    DOI:
    10.1089/ars.2022.0208 - link to the publication
  11. Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia.
    Authors:
    Florczyk-Soluch U, Polak K, Sabo R, Martyniak A, Stępniewski J, Dulak J.
    Academic press:
    Pharmacological Reports (rok: 2023, tom: 75, strony: 1556-1570), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-023-00535-8 - link to the publication
  12. The role of Nrf2 in acute and chronic muscle injury
    Authors:
    Iwona Bronisz-Budzyńska , Magdalena Kozakowska, Paulina Podkalicka, Neli Kachamakova-Trojanowska, Agnieszka Łoboda, Józef Dulak
    Academic press:
    Skeletal Muscle (rok: 2020, tom: 10, strony: 35), Wydawca: BMC Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13395-020-00255-0 - link to the publication
  13. The multifaceted view of heart problem in Duchenne muscular dystrophy.
    Authors:
    Florczyk-Soluch, U., Polak, K., Dulak, J.
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2021, tom: 78, strony: 5447–5468), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-021-03862-2 - link to the publication
  14. Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1)
    Authors:
    Jelinkova S, Martyniak A, Dulak J, Stępniewski J.
    Academic press:
    Stem Cell Research (rok: 2021, tom: 56, strony: 102529), Wydawca: Elcevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2021.102529 - link to the publication
  15. Role of Heme-Oxygenase-1 in Biology of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells.
    Authors:
    Jeż M, Martyniak A, Andrysiak K, Mucha O, Szade K, Kania A, Chrobok Ł, Palus-Chramiec K, Sanetra AM, Lewandowski MH, Pośpiech E, Stępniewski J, Dulak J.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 522), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10030522 - link to the publication
  16. Gene therapy. The legacy of Wacław Szybalski.
    Authors:
    Józef Dulak
    Academic press:
    ACTA BIOCHIMICA POLONICA (rok: 2021, tom: 68, strony: 359-375), Wydawca: Polish Biochemical Society and the Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2020_5805 - link to the publication
  17. Effect of heme oxygenase-1 on the differentiation of human myoblasts and the regeneration of murine skeletal muscles after acute and chronic injury.
    Authors:
    Głowniak-Kwitek U, Caballero AL, Bronisz-Budzyńska I, Kozakowska M, Andrysiak K, Stępniewski J, Łoboda A, Dulak J.
    Academic press:
    Pharamacological Reports (rok: 2023, tom: 75, strony: 397-410), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-023-00475-3 - link to the publication
  18. NRF2 Regulates Viability, Proliferation, Resistance to Oxidative Stress, and Differentiation of Murine Myoblasts and Muscle Satellite Cells
    Authors:
    Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz , Magdalena Madej, Alicja Józkowicz, Agnieszka Łoboda, Józef Dulak
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 3321), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11203321 - link to the publication
  19. Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research
    Authors:
    Andrysiak K, Stępniewski J, Dulak J.
    Academic press:
    Pflügers Archiv : European journal of physiology (rok: 2021, tom: 473, strony: 1061-1085), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00424-021-02536-z - link to the publication
  20. Generation of microRNA-378a-deficient hiPSC as a novel tool to study its role in human cardiomyocytes
    Authors:
    Martyniak A, Andrysiak K, Motais B, Coste S, Podkalicka P, Ferdek P, Stępniewski J, Dulak J.
    Academic press:
    Journal of Molecular and Cellular Cardiology (rok: 2021, tom: 160, strony: 128-141), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.yjmcc.2021.07.007 - link to the publication
  21. Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, in Contrast to Adipose Tissue-Derived Stromal Cells, Efficiently Improve Heart Function in Murine Model of Myocardial Infarction
    Authors:
    Jacek Stepniewski , Mateusz Tomczyk, Kalina Andrysiak , Izabela Kraszewska , Alicja Martyniak , Agnieszka Langrzyk, Klaudia Kulik Ewa Wisniewska,Mateusz Jez, Urszula Florczyk-Soluch, Katarzyna Polak , Paulina Podkalicka, Neli Kachamakova-Trojanowska , Alicja Józkowicz , Agnieszka Jazwa-Kusior and Józef Dulak
    Academic press:
    Biomedicines (rok: 2020, tom: 8, strony: 578), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines8120578 - link to the publication
  22. Adaptation of cardiomyogenesis to the generation and maturation of cardiomyocytes from human pluripotent stem cells
    Authors:
    Martyniak A, Jeż M, Dulak J, Stępniewski J
    Academic press:
    IUBMB Life (rok: 2023, tom: 75, strony: 45898), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/iub.2685 - link to the publication
  23. Casein kinase 2 activity is a host restriction factor for AAV transduction
    Authors:
    Kraszewska I, Sarad K, Andrysiak K, Kopacz A, Schmidt L, Krüger M, Dulak J, Jaźwa-Kusior A
    Academic press:
    Molecular Therapy (rok: 2024, tom: 32, strony: 84-102), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymthe.2023.11.010 - link to the publication
  24. Generation of human induced pluripotent stem cell lines with HMOX1 promoter polymorphism and CRISPR/Cas9-mediated deletion of exon 50 of DMD gene
    Authors:
    Katarzyna Polak, Jacek Stępniewski, Aneta Ścieżyńska, Anna Podgórska , Józef Dulak , Urszula Florczyk-Soluch
    Academic press:
    Stem Cell Research (rok: 2023, tom: 66, strony: 103004), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2022.103004 - link to the publication
  25. Upregulation of utrophin improves the phenotype of Duchenne muscular dystrophy hiPSC-derived CMs
    Authors:
    Andrysiak K, Ferdek PE, Sanetra AM, Machaj G, Schmidt L, Kraszewska I, Sarad K, Palus-Chramiec K, Lis O, Targosz-Korecka M, Krüger M, Lewandowski MH, Ylla G, Stępniewski J, Dulak J.
    Academic press:
    Molecular Therapy Nucleic Acids (rok: 2024, tom: 35, strony: Jun 11;35(3):102247), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.omtn.2024.102247 - link to the publication

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